The BSE 30-share barometer tumbled 527.94 points, or 1.39 per cent, to 35,447.69 in early trade with most of the sectoral indices trading in the negative zone.
The BSE benchmark Sensex cracked over 750 points in early session Thursday as the rupee hit another low amid weak global cues and fears of widening current account deficit.
The international benchmark Brent crude breached the $86 per barrel level, nearing its four-year high.
The 30-share Sensex was down as much as 634 points at 35,341.68 while the 50-share Nifty tumbled over 150 points to 10,663.65.
The laggards include Reliance Industries, Hero MotoCorp, Maruti Suzuki, Bharti Airtel, HDFC, Infosys, Coal India, SBI, HDFC Bank, M&M, IndusInd Bank, Adani Ports, Axis Bank, NTPC, and PowerGrid, falling up to 4.75 per cent.
The gauge had lost nearly 550 points in the previous session Wednesday.
Brokers said weakness was seen in most Asian markets as high US yield and good economic data led to fear that investors would move to the US, dampened trading sentiments here.
The rupee's plunge to a new record low of 73.77 against the dollar by falling 44 paise in early trade, too, weighed on investor mood.
Commerce and Industry Minister Suresh Prabhu will hold an inter-ministerial meeting later in the day to discuss trade deficit and its impact on rupee as well as ways to boost exports, an official told PTI.
Representatives from the department of economic affairs, coal ministry, steel ministry, oil ministry and department of pharmaceuticals are expected to attend the meeting.
Foreign portfolio investors (FPIs) bought shares worth a net of Rs 1,550 crore, while domestic institutional investors (DIIs) made purchases to the tune of Rs 1,402 crore Wednesday.
Elsewhere in Asia, Hong Kong's Hang Seng, Japan, Singapore and Taiwan were trading sharply lower by falling over 1 per cent.
The US Dow Jones Industrial Average, however, ended 0.20 per cent higher Wednesday.