President of the ex-Soviet Uzbekistan, Islam Karimov, six days after he was hospitalised for a suspected brain haemorrhage, officals confirmed on Friday.
"He has left us," Karimov's younger daughter Lola Karimova-Tillyaeva wrote on Instagram. "God bless him."
Karmikov, 78, ruled Uzbekistan as one of the most repressive regimes for 27 years.
He was served as the head of the local Communist Party in 1989 and then as president of the newly independent republic from 1991 when the Soviet Union collapsed.
Karmikov did not designate any political successor. Central Asia analysts have named Mirziyoyev, former regional governor, as a possible heir.
Some senior officials and family members are likely to decide the transition of power. Prolonged lack of a leader could destablise the majority Muslim state that shares a border with Afghanistan and has become a target for Islamist militants.
If they fail to agree on a compromise, however, open confrontation could destabilise the mainly Muslim state of 32 million people, which shares a border with Afghanistan and has become a target for Islamist militants.
The authoritarian leader will be buried in his home city of Samarkand on Saturday. Three days of mourning will be observed.
Russian President Vladimir Putin expressed condolences to acting President Nigmatilla Yuldoshev. The Kremlin quoted Putin as saying his death was a "heavy loss for Uzbekistan".
(WION with inputs from Reuters)