"Hurricane Michael has made landfall just northwest of Mexico beach, Florida," the hurricane center said in its latest update.
The National Hurricane Center describing it as a "potentially catastrophic" Category 4 storm.
It is expected to be the worst hurricane in history in the area. Hurricane Michael was carrying winds as high as 150 mph.
The hurricane has already battered Florida Panhandle city of Apalachicola with rain and wind.
Florida Panhandle is located between Alabama and Georgia on a narrow strip of land in Gulf of Mexico. Georgia, Governor Nathan Deal has already declared a state of emergency for 108 counties in the state although mandatory evacuation orders haven't been issued.
However, residents along the coast in Florida have been ordered to leave their homes.
The last major hurricane, a storm of Category 3 or above, to hit the Panhandle was Dennis in 2005, according to hurricane center data.
"Hurricane Michael is forecast to be the most destructive storm to hit the Florida Panhandle in a century," Governor Rick Scott said, adding "along our coast, communities are going to see unimaginable devastation."
The Florida governor said those who hadn't evacuated, it was already too late for them.
"The National Hurricane Center is expecting storm surge to be between nine and 13 feet (2.7-3.6 meters)," he added. "Water will come miles inshore and could easily rise over the roofs of houses," the governor said.
"The time to evacuate the coastal areas has come and gone... Hunker down, and be careful," he said.
The National Hurricane Centre said Hurricane Micahel would bring wind speeds upto 230 kilometers per hour with waves up to 14 feet high. The storm is also expected to bring heavy rainfall to North and South Carolina which is still recovering from Hurricane Florence.