What is ALS disease that led to Grey's Anatomy star Eric Dane's death? Know about causes, symptoms and more

Actor Eric Dane, widely known for playing the charming Dr Mark Sloan in TV medical drama Grey’s Anatomy, died on Thursday at the age of 53. In April 2025, the popular TV actor revealed that he had been diagnosed with amyotrophic lateral sclerosis (ALS).

On Thursday, Dane’s family released a statement and said that the actor died peacefully earlier in the afternoon, surrounded by close friends, his wife, and daughters, Billie and Georgia. The statement read, "With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS. He spent his final days surrounded by dear friends, his devoted wife, and his two beautiful daughters, Billie and Georgia, who were the center of his world."

Dane was vocal about his ALS diagnosis. Last year, he revealed his diagnosis and stated, “I am grateful to have my loving family by my side as we navigate this next chapter."

Also see: Eric Dane, best known for Grey's Anatomy and Euphoria, dies at 53

Months later, in June 2025, Dane had revealed that he had lost functions in his right arm. While the actor continued raising ALS awareness, the disease spread fast and eventually claimed his life 10 months later.

Dane’s death had come as a shock to many, despite everyone knowing that ALS is fatal.

Dane’s death has brought back focus on ALS and how fast it can progress, leading to death.

WION spoke to Dr Dr Khushbu Goel, Head & Consultant - Stroke Care Programme & Management, Neurology, Manipal Hospitals, Dwarka, New Delhi, and asked about the causes, symptoms of the disease, and preventive measures that one can take if diagnosed.

What is ALS?

ASL or Amyotrophic Lateral Sclerosis, is a progressive, fatal neurodegenerative disease that destroys motor neurons in the brain and spinal cord, causing loss of voluntary muscle control. It mainly includes the motor neurons, which control voluntary muscles located in the brain and spinal cord. When these neurons die, the brain can no longer send signals to muscles, leading to muscle weakness, loss of voluntary movement, and eventual paralysis.

What causes ALS?

Most cases of ALS have no known cause and are known as sporadic. Experts have stated that both genetic and environmental factors often lead to the onset of ALS. According to a report in the Mayo Clinic, 5–10% of ALS cases have a known genetic cause and are often linked to a family history of ALS; such cases are known as familial ALS or hereditary ALS.

Also see: Grey's Anatomy to X-Men: 8 Must-watch films and shows featuring Eric Dane

There is no cure for ALS so far. Once diagnosed, the goal of treatment is aimed at slowing the progress of the disease. It is fatal, with an average survival time of 3 to 5 years after symptoms start, though some live 10 years or more. The progression of the treatment depends on early detection and differs from person ti person.

Symptoms of ALS

According to Dr Goel, “early symptoms of ALS may include muscle spasms and rigidity, arm, leg, or hand weakness, trouble holding objects or walking, difficulty speaking or swallowing. As the disease progresses over time, people may also experience severe muscle weakness and paralysis, loss of the ability to speak, walk, or perform daily tasks, and breathing issues due to involvement of the respiratory muscles. However, as it may lead to physical decline, sensation typically remains normal, and cognitive functions are usually preserved.”

Is it fatal? Does it spread aggressively once diagnosed?

“Yes, ALS can be fatal,” says Dr Goel, and adds that “the progression varies among patients. The development of the disease depends on the site of onset, age, sex, genetic factors, and respiratory function. Limb-onset ALS, which begins in the arms or legs, generally develops more slowly, while bulbar-onset ALS, affecting speech and swallowing, tends to advance more rapidly. Early involvement of the respiratory muscles is associated with a poorer diagnosis. ”

Goel adds that survival rates range from two to five years after diagnosis, but with careful and comprehensive management, some patients may live for ten years or longer.

It is important to clarify that ALS is not a contagious disease and does not spread among individuals.

Is there any way to take precautions or safeguard oneself?

Nutrition: It is essential to have proper nutrition in ALS to avoid weight loss and muscle atrophy. A high-calorie and high-protein diet is necessary to fulfil the energy requirements. Drinking plenty of water is also important to support digestion, circulation, and overall health.

Physical Activity: Exercise must be done in a balanced manner to prevent muscle overuse. Vigorous exercise can worsen muscle fatigue and weakness. Gentle and supervised physiotherapy can also help maintain mobility and flexibility.

Respiratory Care: Breathing function should be checked periodically because weakness of the respiratory muscles is a significant concern in ALS patients. If symptoms like shortness of breath, difficulty breathing when lying flat, a weak cough, or morning headaches occur, medical advice should be immediately sought. Early treatment for breathing difficulties can greatly improve survival and comfort.

Psychological Support: Living with ALS can be emotionally trying for both the patient and the caregiver. Counselling and mental health support can help cope with anxiety, depression, and emotional distress. Support groups can help patients and their families connect with others who have similar experiences and provide valuable information on how to improve their quality of life.