Chasing 378 for victory, the tourists were bowled out for 153 runs.
India thrashed the West Indies by huge 224 runs in the fourth ODI to take a 2-1 lead in the five-match series here on Monday.
Chasing 378 for victory, the tourists were bowled out for 153 runs. The visitors never really had a shot at chasing down this total after they kept losing wickets right from the start.
Rohit Sharma and Ambati Rayudu's brilliant centuries, supported by a disciplined bowling spell by young paceman Khaleel Ahmed and left-arm wrist spinner Kuldeep Yadav, both taking three wickets each, helped to conclude Windies' batting in just 36.2 overs.
Skipper Jason Holder top-scored for the visitors with his unbeaten 54-run knock.
Earlier, centuries from opener Rohit and Rayudu had powered India to a mammoth 377 runs.
While Rohit compensated for his failure in the third ODI by belting another top-notch hundred, the 21st of his career and the second of the series, Rayudu, the newly-anointed No.4 stamped his authority by slamming his 3rd ODI century.
India had won the Guwahati ODI, tied the Vizag match and lost the Pune contest. The final match will be played Thiruvananthapuram on Thursday.