The little blue pill that revolutionised the treatment of erectile dysfunction may have another unexpected role, this time in the fight against cancer. Researchers at Israel's Weizmann Institute of Science have found evidence suggesting that sildenafil, the active ingredient in Viagra, could help slow the spread of cancer by blocking a newly identified biological pathway involved in metastasis.The findings, published in the journal Cancer Research, suggest the decades-old drug may limit cancer cells' ability to use cholesterol, a key ingredient they need to spread to other parts of the body.Also read | <a href="https://www.wionews.com/world/google-earth-accidentally-creates-ai-s-next-misinformation-nightmare-new-feature-rolled-back-over-terrifying-ques-what-s-real-anymore-1785546636794">Google Earth accidentally creates AI's next misinformation nightmare. 'Create image' feature rolled back over terrifying ques: What's real anymore?</a>&nbsp;<h2>How can Viagra slow cancer spread?</h2>Sildenafil was originally developed to improve blood flow before becoming widely known as a treatment for erectile dysfunction. Now, scientists say the same blood vessel-dilating properties may interfere with the way cancer cells access cholesterol.According to the researchers, cholesterol is a crucial building block for cell membranes. Cancer cells that break away from a primary tumour and spread to distant organs rely heavily on cholesterol to survive and establish new tumours.By restricting access to cholesterol, sildenafil appears to make it more difficult for cancer cells to form metastases, the process responsible for most cancer-related deaths.<h2>Statins may make the effect stronger</h2>The researchers believe sildenafil's potential could be enhanced when used alongside statins, medicines commonly prescribed to lower cholesterol. While sildenafil limits cancer cells' ability to utilise existing cholesterol, statins reduce the body's production of new cholesterol.The team says the two drugs together could create a double effect by cutting off both the supply and production of cholesterol available to cancer cells. An analysis of digital health records also found that people taking sildenafil showed significantly better survival rates, with the benefit appearing to increase when the drug was combined with statins.Also read | <a href="https://www.wionews.com/technology/after-openai-s-scary-agent-anthropic-s-claude-goes-rogue-ai-gains-unauthorised-real-world-access-during-testing-1785475339558">After OpenAI's 'scary' agent, Anthropic's Claude goes rogue; AI gains unauthorised 'real-world' access during testing</a><h2>Not a cancer treatment yet</h2>Despite the promising findings, researchers caution that sildenafil is not a proven cancer treatment.The study identifies a potential mechanism and an association seen in health records, but clinical trials will be needed to determine whether the drug can safely and effectively prevent cancer from spreading in patients.Lead researcher Ayelet Erez said the findings highlight that cancer "is shaped not only by mutations in tumour cells but also by the patient’s metabolic state and by medications they are already taking for other conditions".

Researchers at Israel's Weizmann Institute of Science have found that Viagra, may help slow cancer spread by blocking cancer cells' access to cholesterol. While the findings are promising, scientists stress the drug is not yet a proven cancer treatment and clinical trials are still needed.

The little blue pill that revolutionised the treatment of erectile dysfunction may have another unexpected role, this time in the fight against cancer. Researchers at Israel's Weizmann Institute of Science have found evidence suggesting that sildenafil, the active ingredient in Viagra, could help slow the spread of cancer by blocking a newly identified biological pathway involved in metastasis. The findings, published in the journal Cancer Research, suggest the decades-old drug may limit cancer cells' ability to use cholesterol, a key ingredient they need to spread to other parts of the body. Also read | Google Earth accidentally creates AI's next misinformation nightmare. 'Create image' feature rolled back over terrifying ques: What's real anymore? How can Viagra slow cancer spread? Sildenafil was originally developed to improve blood flow before becoming widely known as a treatment for erectile dysfunction. Now, scientists say the same blood vessel-dilating properties may interfere with the way cancer cells access cholesterol. According to the researchers, cholesterol is a crucial building block for cell membranes. Cancer cells that break away from a primary tumour and spread to distant organs rely heavily on cholesterol to survive and establish new tumours. By restricting access to cholesterol, sildenafil appears to make it more difficult for cancer cells to form metastases, the process responsible for most cancer-related deaths. Statins may make the effect stronger The researchers believe sildenafil's potential could be enhanced when used alongside statins, medicines commonly prescribed to lower cholesterol. While sildenafil limits cancer cells' ability to utilise existing cholesterol, statins reduce the body's production of new cholesterol. The team says the two drugs together could create a double effect by cutting off both the supply and production of cholesterol available to cancer cells. An analysis of digital health records also found that people taking sildenafil showed significantly better survival rates, with the benefit appearing to increase when the drug was combined with statins. Also read | After OpenAI's 'scary' agent, Anthropic's Claude goes rogue; AI gains unauthorised 'real-world' access during testing Not a cancer treatment yet Despite the promising findings, researchers caution that sildenafil is not a proven cancer treatment. The study identifies a potential mechanism and an association seen in health records, but clinical trials will be needed to determine whether the drug can safely and effectively prevent cancer from spreading in patients. Lead researcher Ayelet Erez said the findings highlight that cancer "is shaped not only by mutations in tumour cells but also by the patient’s metabolic state and by medications they are already taking for other conditions".

Researchers at Israel's Weizmann Institute of Science have found that Viagra, may help slow cancer spread by blocking cancer cells' access to cholesterol. While the findings are promising, scientists stress the drug is not yet a proven cancer treatment and clinical trials are still needed.

The little blue pill against cancer? Viagra shows surprising promise in new study

Could Viagra, the widely used drug for erectile dysfunction, become part of the fight against cancer?

A new study suggests that sildenafil, commonly known by its brand name Viagra, may help slow the spread of cancer by limiting the ability of cancer cells to use cholesterol—an essential component that helps them migrate and form new tumors.

Researchers say the drug's anti-metastatic effects could become even stronger when combined with statins, which reduce cholesterol production. The findings, published in the journal Cancer Research, also indicate that patients taking sildenafil showed improved survival rates.

While the research is promising, scientists emphasize that more clinical studies are needed before Viagra can be recommended as a cancer treatment.

Viagra May Help Fight Cancer Spread? Scientists Discover Promising New Use for Sildenafil

The FDA-approved medicine sildenafil, which is administered for erectile dysfunction, can soon be part of the therapy to decrease the risk of Alzheimer's disease.

The researchers in the United States, have analysed medical insurance data and carried out a laboratory investigation of sildenafil's genetic and neurological effects. Sildenafil is a drug which is popularly sold under the brand name Viagra.&nbsp;

The researchers in the United States validated the potential of the medication in maintaining critical proteins in nerve cells from getting into a deadly mess.&nbsp;

Recent studies carried out have again and again shown that enzyme blockers known as phosphodiesterase (PDE) inhibitors are not only able to increase blood flow in the penis but can also prevent neurodegeneration which leads to dementia.

The potential of the enzyme blockers should not be surprising since the PDEs are known to remain involved in nerve signalling pathways which influence neuroplasticity.&nbsp;

Also Read: <a href="https://www.wionews.com/science/frequently-nose-picking-leading-cause-of-progressive-dementia-study-687765">Frequent nose-picking leading cause of progressive dementia: Study</a>

As per earlier investigations on animal models, the PDE inhibitor sildenafil decreases the excessive phosphorylation of 'tau' proteins in nerve cells which leads them to form toxic tangles and helps improve cognitive health and memory.

However, some studies were not able to register an effect on the population level at all. &nbsp;

And though, the drug&nbsp;does not have an effect on a neurological level, the mechanism involved in the process is still not fully understood.

<h2>Cell cultures of neurons used by researchers to study Viagra's effect&nbsp;</h2>

In the United States, the researchers used cell cultures of neurons, which were created using stem cells donated by patients with Alzheimer's, to sketch the metabolic and genetic activity behind the therapeutic effects of sildenafil.&nbsp;

After five days of treatment, significantly lower levels of tau proteins were produced by the laboratory-grown neurons in which phosphorus in high concentration was added, which confirmed sildenafil's potential to protect brain cells.

Watch:&nbsp;Celebrities who've been diagnosed with rare diseases &amp; more

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When the researchers went through the messages produced by the DNA of the cells, they found multiple changes in the expression of genes, many of which involved the communication breakdown between nerves, inflammation and guidance of nerve cell structures.

Even though additional studies will be required to understand how these subtle influences are involved in the pathology behind Alzheimer's, the researchers have understood that the main gene families affected by sildenafil gave a solid foundation for understanding why this works and why Alzheimer's is developed in some brains in the first place.

"After integrating this large amount of data computationally, it is rewarding to see sildenafil's effects in human neurons and real-world patient outcomes," said Cleveland Clinic biomedical informatician and co-first author Feixiong Cheng, reported Science Alert.

The FDA-approved medicine sildenafil, which is administered for erectile dysfunction, can soon be part of the therapy to decrease the risk of Alzheimer's disease.

The FDA-approved medicine sildenafil, which is administered for erectile dysfunction, can soon be part of the therapy to decrease the risk of Alzheimer's disease. The researchers in the United States, have analysed medical insurance data and carried out a laboratory investigation of sildenafil's genetic and neurological effects. Sildenafil is a drug which is popularly sold under the brand name Viagra. The researchers in the United States validated the potential of the medication in maintaining critical proteins in nerve cells from getting into a deadly mess. Recent studies carried out have again and again shown that enzyme blockers known as phosphodiesterase (PDE) inhibitors are not only able to increase blood flow in the penis but can also prevent neurodegeneration which leads to dementia. The potential of the enzyme blockers should not be surprising since the PDEs are known to remain involved in nerve signalling pathways which influence neuroplasticity. Also Read: Frequent nose-picking leading cause of progressive dementia: Study As per earlier investigations on animal models, the PDE inhibitor sildenafil decreases the excessive phosphorylation of 'tau' proteins in nerve cells which leads them to form toxic tangles and helps improve cognitive health and memory. However, some studies were not able to register an effect on the population level at all. And though, the drug does not have an effect on a neurological level, the mechanism involved in the process is still not fully understood. Cell cultures of neurons used by researchers to study Viagra's effect In the United States, the researchers used cell cultures of neurons, which were created using stem cells donated by patients with Alzheimer's, to sketch the metabolic and genetic activity behind the therapeutic effects of sildenafil. After five days of treatment, significantly lower levels of tau proteins were produced by the laboratory-grown neurons in which phosphorus in high concentration was added, which confirmed sildenafil's potential to protect brain cells. Watch: Celebrities who've been diagnosed with rare diseases & more When the researchers went through the messages produced by the DNA of the cells, they found multiple changes in the expression of genes, many of which involved the communication breakdown between nerves, inflammation and guidance of nerve cell structures. Even though additional studies will be required to understand how these subtle influences are involved in the pathology behind Alzheimer's, the researchers have understood that the main gene families affected by sildenafil gave a solid foundation for understanding why this works and why Alzheimer's is developed in some brains in the first place. "After integrating this large amount of data computationally, it is rewarding to see sildenafil's effects in human neurons and real-world patient outcomes," said Cleveland Clinic biomedical informatician and co-first author Feixiong Cheng, reported Science Alert.

Viagra intake decreases Alzheimer’s risk by more than 50 per cent: Study

A Spanish priest has been arrested under suspicion of illegally selling Viagra and other potent aphrodisiac substances from his residence. The arrest, which took place in Spain's Extremadura region, involved another person as well.

The priest, whose identity remains undisclosed, was arrested in the town of Don Benito and subsequently charged with criminal offenses. His lawyer has refuted the allegations, asserting their lack of foundation.

Local reports indicate that the priest's arrest followed an extensive investigation into the purported sale of controlled substances, including Viagra. Spanish news outlets suggest that the second individual detained alongside the priest was his romantic partner. Allegedly, the duo conducted sales from their home.

<a href="https://www.wionews.com/science/mystery-genetic-material-in-butterflies-moths-has-not-changed-for-over-250-mn-years-692522">Also read |&nbsp;Mystery? Genetic material in butterflies, moths has not changed for over 250 mn years!</a>

<h2>Police surveillance and action</h2>

On Monday (Feb 19), authorities placed the suspects' property under surveillance before conducting a raid led by the Civil Guard.

While Viagra is legally obtainable from pharmacies in Spain, the nature of the additional substances sold by the accused remains unclear.

<a href="https://www.wionews.com/world/alabamas-largest-hospital-pauses-ivf-after-sc-says-frozen-embryos-are-children-692515">Also read |&nbsp;Alabama's largest hospital pauses IVF after SC says frozen embryos are children</a>

The Diocese of Plasencia, to which the priest's church is affiliated, issued a statement expressing its readiness for further investigation and clarification of the circumstances surrounding the arrest.

It said the church "certainly regret(s) the events described by the pain, suffering and scandal they entail".

(With inputs from agencies)

A Spanish priest has been arrested under suspicion of illegally selling Viagra and other potent aphrodisiac substances from his residence. The arrest, which took place in Spain's Extremadura region, involved another person as well.

A Spanish priest has been arrested under suspicion of illegally selling Viagra and other potent aphrodisiac substances from his residence. The arrest, which took place in Spain's Extremadura region, involved another person as well. The priest, whose identity remains undisclosed, was arrested in the town of Don Benito and subsequently charged with criminal offenses. His lawyer has refuted the allegations, asserting their lack of foundation. Local reports indicate that the priest's arrest followed an extensive investigation into the purported sale of controlled substances, including Viagra. Spanish news outlets suggest that the second individual detained alongside the priest was his romantic partner. Allegedly, the duo conducted sales from their home. Also read | Mystery? Genetic material in butterflies, moths has not changed for over 250 mn years! Police surveillance and action On Monday (Feb 19), authorities placed the suspects' property under surveillance before conducting a raid led by the Civil Guard. While Viagra is legally obtainable from pharmacies in Spain, the nature of the additional substances sold by the accused remains unclear. Also read | Alabama's largest hospital pauses IVF after SC says frozen embryos are children The Diocese of Plasencia, to which the priest's church is affiliated, issued a statement expressing its readiness for further investigation and clarification of the circumstances surrounding the arrest. It said the church "certainly regret(s) the events described by the pain, suffering and scandal they entail". (With inputs from agencies)

Spanish priest held for selling illegal Viagra from home

In their decades-long quest for drugs which can battle Alzheimer’s disease, researchers seem to have found an unlikely candidate: Viagra, the erectile dysfunction pill.

While the study is not conclusive, the researchers discovered that men who were prescribed Viagra as well as similar medications were 18 per cent less likely to suffer from dementia in the later years of their life in comparison to those who were not administered similar drugs.

The effect of Viagra was the strongest in men who were prescribed the medicine a maximum number of times. The scientists found a 44 per cent lower risk of Alzheimer’s in those who were prescribed the erectile dysfunction pills from 21 to 50 times in the course of their study.

Although the findings are astonishing, the observational study was not able to determine if Viagra and similar pills were able to protect people from Alzheimer’s or if the men who were less prone to the condition were just more likely to use the tablets.

Also read:&nbsp;<a href="https://www.wionews.com/science/frequently-nose-picking-leading-cause-of-progressive-dementia-study-687765">Frequent nose-picking leading cause of progressive dementia: Study</a>

“We can’t say that the drugs are responsible, but this does give us food for thought on how we move into the future,” stated the lead author Dr Ruth Brauer at University College London.&nbsp;

“We now need a proper clinical trial to look at the effects of these drugs on Alzheimer’s in women as well as men," he added, The Guardian newspaper reported.&nbsp;

<h2>Study examined&nbsp;260,000 men who were&nbsp;diagnosed with erectile dysfunction</h2>

For the study, medical records of more than 260,000 men were analysed by Brauer and her colleagues who were diagnosed with erectile dysfunction, although they had no evidence of memory loss or were facing thinking problems.

More than half of them were consuming PDE5 inhibitor drugs, ranging from avanafil, vardenafil, tadalafil and sildenafil (sold as Viagra).&nbsp;

The researchers followed the men for an average of five years to record any new cases of Alzheimer’s.&nbsp;

Watch:&nbsp;17-Year-Old Hemesh's miracle tech gives new hope to Alzheimer's patients

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Around 55 million people have been suffering from dementia around the world, and most of them have Alzheimer's.&nbsp;

The new drugs which clear aberrant proteins from the brain have proved that they can slow down the disease, however, the effects of the medicines have been marginal.

Originally, Viagra was developed for treating angina and high blood pressure. 
 
When Welsh miners participated in a trial in Merthyr Tydfil and spoke about its unexpected night-time side effects, the drug gained fame as a multibillion-dollar erectile dysfunction pill.

(With inputs from agencies)

In their decades-long quest for drugs which can battle Alzheimer’s disease, researchers seem to have found an unlikely candidate: Viagra, the erectile dysfunction pill.

In their decades-long quest for drugs which can battle Alzheimer’s disease, researchers seem to have found an unlikely candidate: Viagra, the erectile dysfunction pill. While the study is not conclusive, the researchers discovered that men who were prescribed Viagra as well as similar medications were 18 per cent less likely to suffer from dementia in the later years of their life in comparison to those who were not administered similar drugs. The effect of Viagra was the strongest in men who were prescribed the medicine a maximum number of times. The scientists found a 44 per cent lower risk of Alzheimer’s in those who were prescribed the erectile dysfunction pills from 21 to 50 times in the course of their study. Although the findings are astonishing, the observational study was not able to determine if Viagra and similar pills were able to protect people from Alzheimer’s or if the men who were less prone to the condition were just more likely to use the tablets. Also read: Frequent nose-picking leading cause of progressive dementia: Study “We can’t say that the drugs are responsible, but this does give us food for thought on how we move into the future,” stated the lead author Dr Ruth Brauer at University College London. “We now need a proper clinical trial to look at the effects of these drugs on Alzheimer’s in women as well as men," he added, The Guardian newspaper reported. Study examined 260,000 men who were diagnosed with erectile dysfunction For the study, medical records of more than 260,000 men were analysed by Brauer and her colleagues who were diagnosed with erectile dysfunction, although they had no evidence of memory loss or were facing thinking problems. More than half of them were consuming PDE5 inhibitor drugs, ranging from avanafil, vardenafil, tadalafil and sildenafil (sold as Viagra). The researchers followed the men for an average of five years to record any new cases of Alzheimer’s. Watch: 17-Year-Old Hemesh's miracle tech gives new hope to Alzheimer's patients Around 55 million people have been suffering from dementia around the world, and most of them have Alzheimer's. The new drugs which clear aberrant proteins from the brain have proved that they can slow down the disease, however, the effects of the medicines have been marginal. Originally, Viagra was developed for treating angina and high blood pressure. When Welsh miners participated in a trial in Merthyr Tydfil and spoke about its unexpected night-time side effects, the drug gained fame as a multibillion-dollar erectile dysfunction pill. (With inputs from agencies)

Study finds Viagra linked to decreased risk of Alzheimer’s disease

Ahead of mega Sankranti celebrations in rural areas of the southern Indian state of Andhra Pradesh, breeders are feeding their chickens with Viagra and Shilajit (a natural organic-mineral product formed in mountains) besides other steroid-laced food. That explains how competitive the world of cockfighting in this part of the subcontinent is.&nbsp;

Cockfights are an integral, essential part of Sankranti celebrations in rural Andhra Pradesh where crores and crores of rupees are often at stake during festival betting.

As a part of the celebrations, trained roosters engage in intense ‘fights to the death’, while a cheering crowd bets on the winning side. This year, the festival will be celebrated from January 14 to 16.&nbsp;

However, this year, the outbreak of a disease called ‘Ranikhet’ has cast a shadow on the tradition of this rooster fight. The disease has left several trained roosters weakened and unfit for fight, leading their owners to resort to unconventional methods to shore them up.&nbsp;

<a href="https://www.wionews.com/india-news/lok-sabha-poll-india-alliances-seat-sharing-in-bihar-finalised-details-here-677554">Also read:&nbsp;Lok Sabha poll: INDIA alliance’s seat sharing in Bihar finalised. Details here</a>

An investigation by the Times of India found that several breeders were blatantly making the roosters consume aphrodisiacs meant only for humans, without even considering whether the practice actually boosted the fighting spirit of the chickens or not.

“We spent a fortune on saving the fighting breed of birds from the disease. But what we found was that the birds are now lacking in strength. This is the short-cut to make the birds ready for Sankranti," a breeder was quoted as saying by the Times of India.

Watch:&nbsp;Watch: Cock-fighting tournament held at Indian tribal festival

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However, experts have warned that the practice might lead to an enhanced performance for some time but it will cripple the birds in the long run. The consumption of aphrodisiacs might also lead to mutations in the birds, which could prove to be severely harmful when consumed by humans. While these unorthodox drugs are being introduced to the birds for the first time, their actual impact on enhancing fighting spirit in roosters remains unclear.&nbsp;

(With inputs from agencies)

Ahead of mega Sankranti celebrations in rural areas of the southern Indian state of Andhra Pradesh, breeders are feeding their chickens with Viagra and Shilajit (a natural organic-mineral product formed in mountains) besides other steroid-laced food.

Ahead of mega Sankranti celebrations in rural areas of the southern Indian state of Andhra Pradesh, breeders are feeding their chickens with Viagra and Shilajit (a natural organic-mineral product formed in mountains) besides other steroid-laced food. That explains how competitive the world of cockfighting in this part of the subcontinent is. Cockfights are an integral, essential part of Sankranti celebrations in rural Andhra Pradesh where crores and crores of rupees are often at stake during festival betting. As a part of the celebrations, trained roosters engage in intense ‘fights to the death’, while a cheering crowd bets on the winning side. This year, the festival will be celebrated from January 14 to 16. However, this year, the outbreak of a disease called ‘Ranikhet’ has cast a shadow on the tradition of this rooster fight. The disease has left several trained roosters weakened and unfit for fight, leading their owners to resort to unconventional methods to shore them up. Also read: Lok Sabha poll: INDIA alliance’s seat sharing in Bihar finalised. Details here An investigation by the Times of India found that several breeders were blatantly making the roosters consume aphrodisiacs meant only for humans, without even considering whether the practice actually boosted the fighting spirit of the chickens or not. “We spent a fortune on saving the fighting breed of birds from the disease. But what we found was that the birds are now lacking in strength. This is the short-cut to make the birds ready for Sankranti," a breeder was quoted as saying by the Times of India. Watch: Watch: Cock-fighting tournament held at Indian tribal festival × However, experts have warned that the practice might lead to an enhanced performance for some time but it will cripple the birds in the long run. The consumption of aphrodisiacs might also lead to mutations in the birds, which could prove to be severely harmful when consumed by humans. While these unorthodox drugs are being introduced to the birds for the first time, their actual impact on enhancing fighting spirit in roosters remains unclear. (With inputs from agencies)

India: Chickens being fed Viagra and Shilajit ahead of cockfight season

Orlando Police arrested a man for attempting an armed robbery at a drugstore. The 23-year-old Thomas Mues walked into a CVS drugstore in Orlando, Florida, and handed a handwritten note to the employees saying he would shoot someone unless they gave him all the oxycodone, hydrocodone, Xanax, Adderall, liquid codeine and Viagra bottles, NBS News reported.

Orlando Police arrested a man for attempting an armed robbery at a drugstore. The 23-year-old Thomas Mues walked into a CVS drugstore in Orlando, Florida, and handed a handwritten note to the employees saying he would shoot someone unless they gave him all the oxycodone, hydrocodone, Xanax, Adderall, liquid codeine and Viagra bottles, NBS News reported. The Orlando Police shared a handwritten note on X. The post said, "The suspect armed with this note detailing a long list of specific demands." According to the post, the Orlando Police officers responded to a CBS in the 4300 block of Curry Ford Road for a commercial robbery. They arrested the man on October 20 at 6 pm local time. The cops apprehended him with dozens of bottles of pills. ALSO READ | UK: Snails take up residence in Devon postbox; feast on envelope glue He wrote in the handwritten note, "THIS IS A ARMED ROBBERY!!!" "Please cooperate. I don't want to hurt you. You are not to alarm anybody, or I will shoot the closest person to me! Please follow these directions, or I will shoot the closest person to me," the note said. In the note, he asked the drugstore to bag these items: Oxycodone: 5mg, 7.5mg, 15mg, 20 mg, 30 mg (all bottles) Hydrocodone: 5mg, 7.5mg, 10mg (all bottles) Xanax: 2mg, 1mg (all bottles) Adderall: 20mg, 30mg, 75 mg (all bottles) Liquid Codeine/Prometh (all bottles) Viagra: 100mg (all bottles) At the end of the note, he wrote, "When finished, place note in the bag and lay down or I will shoot." ALSO READ | Captive Hamas militant reveals $10K reward & an apartment were on offer to lure them into bringing hostages In another post on X, the Orlando Police said, "Pharmacy employees say the suspect handed them a note indicating he had a gun & would shoot them if he was not provided the pills listed. OPD TAC officers arrived on the scene as the suspect, Thomas Mues (DOB 2/22/00), was walking out of the store." The man will face several robbery, trafficking, and possession charges, the police said. He travelled from Jacksonville to Orlando for the theft. He has also confessed to a similar robbery in Central Florida. Orlando Police applauded OPD's TAC officers and criminal investigations division. (With inputs from agencies)

Man threatens Florida pharmacy, demands all Viagra bottles and other drugs to be handed over

Health officials in Australia have issued a public warning advising men to avoid "Big Penis USA" pills after discovering they contained&nbsp;sildenafil —&nbsp;the erectile dysfunction medication sold under the brand name Viagra.&nbsp;

The Therapeutic Goods Administration (TGA) released a public service announcement, cautioning men to avoid taking the pill.&nbsp;

“Big Penis USA tablets pose a serious risk to your health and should not be taken,” the TGA said.&nbsp;

"The tablets contain the undeclared substance sildenafil.&nbsp;It may interact with nitrates found in some prescription drugs and may lower blood pressure to dangerous levels," it added, declaring the supply of the pill as illegal.&nbsp;

Sildenafil is a prescription-only drug, used to treat erectile dysfunction.&nbsp;If&nbsp;combined with certain prescription medicines, the dosage can be potentially fatal, the public health watchdog said.&nbsp;

<h2>TGA joins forces with ABF</h2>

The TGA has joined forces with the&nbsp;Australian Border Force (ABF) to stop future shipments of Big Penis USA tables from entering the Down Under country.

"Big Penis USA tablets have not been assessed by the TGA for quality, safety or efficacy as required under Australian legislation, and the place of manufacture is not approved by the TGA."

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Notably, the pill is not sold in Australian stores. However, owing to its wild internet popularity, Australian men had been purchasing the product online.&nbsp;

"The TGA is advising consumers to exercise extreme caution when purchasing medicines from unknown overseas Internet sites and has produced a short video on the risks associated with buying medicines and medical devices online."

The ABF will be seizing and destroying any Big Penis USA products that are intercepted at the border.&nbsp;

<h2>US FDA issued similar warning</h2>

Previously, the US&nbsp;Federal Drug Administration had also issued a similar warning advisory about the Big Penis USA pills for the exact same reason. After examining the international mail shipments of the product, FDA found&nbsp;high, undisclosed amount of&nbsp;sildenafil in the pills.

"The Food and Drug Administration (FDA) is advising consumers not to purchase or use Big Penis Male Sexual Stimulant, a product promoted for sexual enhancement. This product was identified by FDA during an examination of international mail shipments," the health watchdog said in 2016.&nbsp;

<a href="https://www.wionews.com/videos/japan-to-ban-recording-upskirting-non-consensual-sexual-videos-trending-on-wion-588258">WATCH |&nbsp;Japan to ban recording upskirting &amp; non-consensual sexual videos | Trending on WION</a>

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"Health care professionals and patients are encouraged to report adverse events or side effects related to the use of this product to the FDA's MedWatch Safety Information and Adverse Event Reporting Program," it added.&nbsp;

(With inputs from agencies) 
 
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WATCH WION LIVE HERE:&nbsp;

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Health officials in Australia have issued a public warning advising men to avoid "Big Penis USA" pills after discovering they contained sildenafil — the erectile dysfunction medication sold under the brand name Viagra.

Health officials in Australia have issued a public warning advising men to avoid "Big Penis USA" pills after discovering they contained sildenafil — the erectile dysfunction medication sold under the brand name Viagra. The Therapeutic Goods Administration (TGA) released a public service announcement, cautioning men to avoid taking the pill. “Big Penis USA tablets pose a serious risk to your health and should not be taken,” the TGA said. "The tablets contain the undeclared substance sildenafil. It may interact with nitrates found in some prescription drugs and may lower blood pressure to dangerous levels," it added, declaring the supply of the pill as illegal. Sildenafil is a prescription-only drug, used to treat erectile dysfunction. If combined with certain prescription medicines, the dosage can be potentially fatal, the public health watchdog said. TGA joins forces with ABF The TGA has joined forces with the Australian Border Force (ABF) to stop future shipments of Big Penis USA tables from entering the Down Under country. "Big Penis USA tablets have not been assessed by the TGA for quality, safety or efficacy as required under Australian legislation, and the place of manufacture is not approved by the TGA." Also read | NUTS! Woodpeckers stash 300 kg of acorns in a California home Notably, the pill is not sold in Australian stores. However, owing to its wild internet popularity, Australian men had been purchasing the product online. "The TGA is advising consumers to exercise extreme caution when purchasing medicines from unknown overseas Internet sites and has produced a short video on the risks associated with buying medicines and medical devices online." The ABF will be seizing and destroying any Big Penis USA products that are intercepted at the border. US FDA issued similar warning Previously, the US Federal Drug Administration had also issued a similar warning advisory about the Big Penis USA pills for the exact same reason. After examining the international mail shipments of the product, FDA found high, undisclosed amount of sildenafil in the pills. "The Food and Drug Administration (FDA) is advising consumers not to purchase or use Big Penis Male Sexual Stimulant, a product promoted for sexual enhancement. This product was identified by FDA during an examination of international mail shipments," the health watchdog said in 2016. WATCH | Japan to ban recording upskirting & non-consensual sexual videos | Trending on WION × "Health care professionals and patients are encouraged to report adverse events or side effects related to the use of this product to the FDA's MedWatch Safety Information and Adverse Event Reporting Program," it added. (With inputs from agencies) WATCH WION LIVE HERE:

'Big Penis USA' pills banned in Australia for containing hidden drug ingredient

Downplaying the controversy that has emerged over the Brazilian military’s purchase of Viagra and penile implants, the country’s President Jair Bolsonaro attacked the media for “swelling” the issue.

Just two days after the revelations were made by congressman Eliaz Vaz, Bolsonaro the far-right president during a meeting with Evangelical Christian ministers at the presidential palace said that "it was maybe 50,000 pills total. With all due respect, that's nothing."

Also read |&nbsp;<a href="https://www.wionews.com/world/you-are-beyond-essential-on-womens-day-brazils-sexist-president-backtracks-from-menstrual-poverty-row-460412">'You are beyond essential': On women's day, Brazil's sexist President backtracks from 'menstrual poverty' row</a>

He went on to say, “obviously, that's mostly for retirees and inactive service members," repeating the defence ministry's claim that the medicine would be used by the military to treat high blood pressure and rheumatism.

Vaz had made the revelation not only about a sizeable order of sildenafil, the active ingredient in drugs used to treat erectile dysfunction but also about the purchase of 60 penile prostheses.

Bolsonaro, a former army captain, remained silent on the most recent revelation that the military had obtained 60 penile implants.

Instead, he said, "we take abuse every day from a press that acts in very bad faith and is ignorant on the matter."

Watch |&nbsp;Gravitas: Bolsonaro sceptic on Vaccine side-effects

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According to Vaz, the ministry purchased the penile implants for three different military hospitals for a total cost of between 50,000 and 60,000 reais (about $10,600 to $12,800). Over $700,000 was spent on the project in total.

The revelations have triggered a slew of jokes on social media, most of them directed at Bolsanaro himself. We've selected the best ones for you:

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Licitação das forças armadas com Bolsonaro 
 
Expectativa: 
- Mísseis 
- Tanques 
- Fuzis 
- Caças 
 
Realidade: 
- Viagra 
- Remédio pra Calvice 
- Leite condensado 
- Picanha 
- Cerveja 
 
O quartel virou um grande bacanal.
— Rubinho Nunes (@RubensNunesMBL) <a href="https://twitter.com/RubensNunesMBL/status/1513836256999976962?ref_src=twsrc%5Etfw">April 12, 2022</a></blockquote>
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<a href="https://twitter.com/hashtag/viagra?src=hash&amp;ref_src=twsrc%5Etfw">#viagra</a> <a href="https://twitter.com/hashtag/Pfizer?src=hash&amp;ref_src=twsrc%5Etfw">#Pfizer</a> <a href="https://twitter.com/hashtag/Bolsonaro?src=hash&amp;ref_src=twsrc%5Etfw">#Bolsonaro</a> <a href="https://t.co/dJX3jbOSR5">pic.twitter.com/dJX3jbOSR5</a>
— Pastelaria Gabiru (@gabgakas) <a href="https://twitter.com/gabgakas/status/1513636286686507010?ref_src=twsrc%5Etfw">April 11, 2022</a></blockquote>
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Remember when the lie that Muammar Gaddafi was giving Viagra to his troops was used as war propaganda to help destroy Africa's wealthiest nation (per capita)? The Bolsonaro administration has just admitted purchasing 35,000 Viagra pills for the military. <a href="https://t.co/FEnaMc5h1d">pic.twitter.com/FEnaMc5h1d</a>
— BrianMier (@BrianMteleSUR) <a href="https://twitter.com/BrianMteleSUR/status/1513677577814257665?ref_src=twsrc%5Etfw">April 12, 2022</a></blockquote>
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(With inputs from agencies)

Downplaying the controversy that has emerged over the Brazilian military’s purchase of Viagra and penile implants, the country’s President Jair Bolsonaro attacked the media for “swelling” the issue.

Downplaying the controversy that has emerged over the Brazilian military’s purchase of Viagra and penile implants, the country’s President Jair Bolsonaro attacked the media for “swelling” the issue. Just two days after the revelations were made by congressman Eliaz Vaz, Bolsonaro the far-right president during a meeting with Evangelical Christian ministers at the presidential palace said that "it was maybe 50,000 pills total. With all due respect, that's nothing." Also read | 'You are beyond essential': On women's day, Brazil's sexist President backtracks from 'menstrual poverty' row He went on to say, “obviously, that's mostly for retirees and inactive service members," repeating the defence ministry's claim that the medicine would be used by the military to treat high blood pressure and rheumatism. Vaz had made the revelation not only about a sizeable order of sildenafil, the active ingredient in drugs used to treat erectile dysfunction but also about the purchase of 60 penile prostheses. Bolsonaro, a former army captain, remained silent on the most recent revelation that the military had obtained 60 penile implants. Instead, he said, "we take abuse every day from a press that acts in very bad faith and is ignorant on the matter." Watch | Gravitas: Bolsonaro sceptic on Vaccine side-effects According to Vaz, the ministry purchased the penile implants for three different military hospitals for a total cost of between 50,000 and 60,000 reais (about $10,600 to $12,800). Over $700,000 was spent on the project in total. The revelations have triggered a slew of jokes on social media, most of them directed at Bolsanaro himself. We've selected the best ones for you: Licitação das forças armadas com Bolsonaro Expectativa: - Mísseis - Tanques - Fuzis - Caças Realidade: - Viagra - Remédio pra Calvice - Leite condensado - Picanha - Cerveja O quartel virou um grande bacanal. — Rubinho Nunes (@RubensNunesMBL) April 12, 2022 × #viagra #Pfizer #Bolsonaro pic.twitter.com/dJX3jbOSR5 — Pastelaria Gabiru (@gabgakas) April 11, 2022 × Remember when the lie that Muammar Gaddafi was giving Viagra to his troops was used as war propaganda to help destroy Africa's wealthiest nation (per capita)? The Bolsonaro administration has just admitted purchasing 35,000 Viagra pills for the military. pic.twitter.com/FEnaMc5h1d — BrianMier (@BrianMteleSUR) April 12, 2022 × (With inputs from agencies)

Brazil's Bolsonaro gets trolled hard for downplaying military's viagra, penile implants order

Viagra is a boon for men with erectile dysfunction but a new study says that the pill, often mentioned as a 'wonder pill' may also be linked to reduced risk of Alzheimer's disease.

The study found that Sildenafil, the drug used in Viagra reduced risk of Alzheimer's by whopping 69 per cent. Result of the study has been published in the journal Nature Aging.

A team from Cleveland Clinic analysed a database of more than 7 million patients, and used computational methodology to screen and validate over 1,600 FDA-approved drugs as potential therapies for Alzheimer`s.

The buildup of beta amyloid and tau proteins in the brain leads to amyloid plaques and tau neurofibrillary tangles -- two hallmarks of Alzheimer`s-related brain changes. The team pinpointed drugs that target both amyloid and tau as having higher scores compared to drugs that target just one or the other.

"Sildenafil, which has been shown to significantly improve cognition and memory in preclinical models, presented as the best drug candidate," said Feixiong Cheng, from Cleveland Clinic`s Genomic Medicine Institute.

Further, the analysis included patients using comparator drugs that either were in an active Alzheimer`s clinical trial (losartan or metformin) or were not yet reported as relevant to the disease (diltiazem or glimepiride).

They found that sildenafil users were 69 per cent less likely to develop Alzheimer`s disease than non-sildenafil users after 6 years of follow-up. Specifically, sildenafil had a 55 per cent reduced risk of the disease compared to losartan, 63 per cent compared to metformin, 65 per cent compared to diltiazem and 64 per cent compared to glimepiride.

"Notably, we found that sildenafil use reduced the likelihood of Alzheimer`s in individuals with coronary artery disease, hypertension and Type-2 diabetes, all of which are comorbidities significantly associated with risk of the disease, as well as in those without," Cheng said.

The researchers also developed an Alzheimer`s patient-derived brain cell model using stem cells.

In the model, they found that sildenafil increased brain cell growth and decreased hyperphosphorylation of tau proteins -- a hallmark which leads to neurofibrillary tangles --, offering biological insights into how sildenafil may influence disease-related brain changes.

(With inputs from agencies)

Viagra is a boon for men with erectile dysfunction but a new study says that the pill, often mentioned as a 'wonder pill' may also be linked to reduced risk of Alzheimer's disease.

Viagra is a boon for men with erectile dysfunction but a new study says that the pill, often mentioned as a 'wonder pill' may also be linked to reduced risk of Alzheimer's disease. The study found that Sildenafil, the drug used in Viagra reduced risk of Alzheimer's by whopping 69 per cent. Result of the study has been published in the journal Nature Aging. A team from Cleveland Clinic analysed a database of more than 7 million patients, and used computational methodology to screen and validate over 1,600 FDA-approved drugs as potential therapies for Alzheimer`s. The buildup of beta amyloid and tau proteins in the brain leads to amyloid plaques and tau neurofibrillary tangles -- two hallmarks of Alzheimer`s-related brain changes. The team pinpointed drugs that target both amyloid and tau as having higher scores compared to drugs that target just one or the other. "Sildenafil, which has been shown to significantly improve cognition and memory in preclinical models, presented as the best drug candidate," said Feixiong Cheng, from Cleveland Clinic`s Genomic Medicine Institute. Further, the analysis included patients using comparator drugs that either were in an active Alzheimer`s clinical trial (losartan or metformin) or were not yet reported as relevant to the disease (diltiazem or glimepiride). They found that sildenafil users were 69 per cent less likely to develop Alzheimer`s disease than non-sildenafil users after 6 years of follow-up. Specifically, sildenafil had a 55 per cent reduced risk of the disease compared to losartan, 63 per cent compared to metformin, 65 per cent compared to diltiazem and 64 per cent compared to glimepiride. "Notably, we found that sildenafil use reduced the likelihood of Alzheimer`s in individuals with coronary artery disease, hypertension and Type-2 diabetes, all of which are comorbidities significantly associated with risk of the disease, as well as in those without," Cheng said. The researchers also developed an Alzheimer`s patient-derived brain cell model using stem cells. In the model, they found that sildenafil increased brain cell growth and decreased hyperphosphorylation of tau proteins -- a hallmark which leads to neurofibrillary tangles --, offering biological insights into how sildenafil may influence disease-related brain changes. (With inputs from agencies)

Viagra can reduce risk of Alzheimer's, says study

South Korean researchers say high traces of Viagra and other drugs used to treat erectile dysfunction were found in Seoul's wastewaters, and their presence in the urban area is expected to increase.

The presence of the chemicals used in the drugs -- Phosphodiesterase-5 inhibitors (PDE-51) -- were high on weekends and in sewage treatment facilities in Gangnam, which is home to nightclubs, bars and red-light spots, new research showed.

"We estimated that the amount of PDE-5i consumption was 31 per cent higher than in areas with fewer nightlife spots," the researchers said in the research paper carried by the Scientific Reports earlier this month.

Experts studied the presence of the chemicals in the influent and effluent of two sewage treatment plants (STPs) in the South Korean capital as well as the receiving water bodies.

Their investigation indicated that the existing sewage treatment plants were "unable to handle" the amounts of the residual chemicals.

"The PDE-5i in domestic wastewater was barely treated by the STPs and, eventually, discharged into the water environment," the research paper said.

"Considering the increasing market size, it is easily expected that more PDE-5i will be discharged in an urban area," it added.

Around 23 per cent of South Korean males aged 30 to 39 are suffering from erectile dysfunction, studies show, and the total PDE-5i sales of the top 20 Korean pharmaceutical companies reached $133 million in 2019.

Due to their effectiveness in improving male sexual performance, the chemical is also often illegally used as an ingredient of tonic medicines, diet supplements, and herbal dietary products in many countries.

A recent study found PDE-5i and their analogues in 80 out of 188 foods and dietary supplements sold in Korea.

Around 322 million patients to suffer from erectile dysfunction in 2025, with the prevalence of the disorder in Asia, projected to jump from 87 million in 1995 to 200 million in 2025 due to the ageing population.

South Korean researchers say high traces of Viagra and other drugs used to treat erectile dysfunction were found in Seoul's wastewaters, and their presence in the urban area is expected to increase.

South Korean researchers say high traces of Viagra and other drugs used to treat erectile dysfunction were found in Seoul's wastewaters, and their presence in the urban area is expected to increase. The presence of the chemicals used in the drugs -- Phosphodiesterase-5 inhibitors (PDE-51) -- were high on weekends and in sewage treatment facilities in Gangnam, which is home to nightclubs, bars and red-light spots, new research showed. "We estimated that the amount of PDE-5i consumption was 31 per cent higher than in areas with fewer nightlife spots," the researchers said in the research paper carried by the Scientific Reports earlier this month. Experts studied the presence of the chemicals in the influent and effluent of two sewage treatment plants (STPs) in the South Korean capital as well as the receiving water bodies. Their investigation indicated that the existing sewage treatment plants were "unable to handle" the amounts of the residual chemicals. "The PDE-5i in domestic wastewater was barely treated by the STPs and, eventually, discharged into the water environment," the research paper said. "Considering the increasing market size, it is easily expected that more PDE-5i will be discharged in an urban area," it added. Around 23 per cent of South Korean males aged 30 to 39 are suffering from erectile dysfunction, studies show, and the total PDE-5i sales of the top 20 Korean pharmaceutical companies reached $133 million in 2019. Due to their effectiveness in improving male sexual performance, the chemical is also often illegally used as an ingredient of tonic medicines, diet supplements, and herbal dietary products in many countries. A recent study found PDE-5i and their analogues in 80 out of 188 foods and dietary supplements sold in Korea. Around 322 million patients to suffer from erectile dysfunction in 2025, with the prevalence of the disorder in Asia, projected to jump from 87 million in 1995 to 200 million in 2025 due to the ageing population.

High traces of Viagra, other drugs found in South Korea's Seoul sewers, shows research

An Indian national was held at the Chicago airport for unlawful import of 3,200 pills of viagra worth over USD 96,000.

The passenger, whose identity has not been revealed, had travelled back to the US from India and was caught with the tablets during a baggage scan, the US Customs and Border Protection (CBP) said in a statement on Friday.

The officials said the passenger was held by the authorities after he could not give a satisfactory justification for carrying such high quantity of viagra tablets -- 3,200 Sildenafil Citrate tablets (100 mg).&nbsp;

"When the traveller was asked why he was in possession of the pills he stated they were for his friends and they are considered over the counter medication in India," the CBP said in a statement.

The nine pounds of pills were then seized for unlawful importation of mediation. The pills have an estimated manufacturer's suggested retail price (MSRP) of approximately USD 96,608.

CBP said that as a general rule the Food and Drug Administration does not allow the importation of prescription drugs that were purchased outside the US.

An Indian national was held at the Chicago airport for unlawful import of 3,200 pills of viagra worth over USD 96,000. The passenger, whose identity has not been revealed, had travelled back to the US from India and was caught with the tablets during a baggage scan, the US Customs and Border Protection (CBP) said in a statement on Friday.

An Indian national was held at the Chicago airport for unlawful import of 3,200 pills of viagra worth over USD 96,000. The passenger, whose identity has not been revealed, had travelled back to the US from India and was caught with the tablets during a baggage scan, the US Customs and Border Protection (CBP) said in a statement on Friday. The officials said the passenger was held by the authorities after he could not give a satisfactory justification for carrying such high quantity of viagra tablets -- 3,200 Sildenafil Citrate tablets (100 mg). "When the traveller was asked why he was in possession of the pills he stated they were for his friends and they are considered over the counter medication in India," the CBP said in a statement. The nine pounds of pills were then seized for unlawful importation of mediation. The pills have an estimated manufacturer's suggested retail price (MSRP) of approximately USD 96,608. CBP said that as a general rule the Food and Drug Administration does not allow the importation of prescription drugs that were purchased outside the US.

Indian held at Chicago airport with 3,200 viagra pills

Director Spike Lee, best known for making movies about the experience of being Black in America, is switching course with a musical - on the subject of Viagra.

Lee will direct the as-yet-untitled film from a screenplay he has co-written about the discovery and launch of the erectile dysfunction drug. It is based on a 2018 article in Esquire magazine called “All Rise,” producers said on Tuesday.

Original songs and music will be written by the duo behind the 2008 Tony-award winning rock musical “Passing Strange,” about a Black artist’s journey of self discovery.

The 63-year-old Brooklyn native said in a statement that he had grown up hating musicals despite the efforts of his mother. “Finally Going Into My 4th Decade As A Filmmaker I Will Be Directing A DANCIN’, ALL SINGIN’ MUSICAL,” he added.

Lee also directed a movie musical in 1988 called “School Daze.”

Pfizer Inc’s Viagra, first marketed in 1998, was originally developed as a potential treatment for heart-related chest pain.

Lee won his first Oscar in 2019 for the screenplay of Ku Klux Klan satire “BlacKkKlansman.” His more than 50 movies and documentaries include classics such as “Do the Right Thing,” “Malcolm X” and this year’s Vietnam War survivor drama “Da 5 Bloods.”

Director Spike Lee, best known for making movies about the experience of being Black in America, is switching course with a musical - on the subject of Viagra. Lee will direct the as-yet-untitled film from a screenplay he has co-written about the discovery and launch of the erectile dysfunction drug.

Director Spike Lee, best known for making movies about the experience of being Black in America, is switching course with a musical - on the subject of Viagra. Lee will direct the as-yet-untitled film from a screenplay he has co-written about the discovery and launch of the erectile dysfunction drug. It is based on a 2018 article in Esquire magazine called “All Rise,” producers said on Tuesday. Original songs and music will be written by the duo behind the 2008 Tony-award winning rock musical “Passing Strange,” about a Black artist’s journey of self discovery. The 63-year-old Brooklyn native said in a statement that he had grown up hating musicals despite the efforts of his mother. “Finally Going Into My 4th Decade As A Filmmaker I Will Be Directing A DANCIN’, ALL SINGIN’ MUSICAL,” he added. Lee also directed a movie musical in 1988 called “School Daze.” Pfizer Inc’s Viagra, first marketed in 1998, was originally developed as a potential treatment for heart-related chest pain. Lee won his first Oscar in 2019 for the screenplay of Ku Klux Klan satire “BlacKkKlansman.” His more than 50 movies and documentaries include classics such as “Do the Right Thing,” “Malcolm X” and this year’s Vietnam War survivor drama “Da 5 Bloods.”

Director Spike Lee changes direction with musical about Viagra

27 March in history: Twenty-two years ago today, Viagra was approved for commercial use

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