<p>Matthew Perry's cause of death has been disclosed as stemming from the acute effects of ketamine, a potent anesthetic that has found diverse applications in both medical and experimental psychiatric treatments. Perry, widely known for his role as Chandler Bing in the iconic television series <em>Friends</em>, was undergoing ketamine infusion therapy — a procedure intended to address severe depression and anxiety. The revelation from the medical examiner's report has brought to light the specific circumstances surrounding Perry's tragic demise.</p>

<h2><strong>What is Ketamine?</strong></h2>

<p>Ketamine, chemically classified as a dissociative anesthetic, has long been employed in medical settings for inducing and maintaining anesthesia during surgical procedures. Its ability to produce sedation, analgesia, and dissociation from the surrounding environment has made it a valuable tool in various medical contexts. However, the past decade has witnessed an expansion of its use beyond its traditional role, particularly in the field of mental health.</p>

<p>Also Read |&nbsp;<strong><a href="https://www.wionews.com/entertainment/hollywood/news-matthew-perrys-cause-of-death-revealed-670158">Matthew Perry's cause of death revealed</a></strong></p>

<h2><strong>Ketamine infusion therapy</strong></h2>

<p>Ketamine infusion therapy represents one such off-label application, where controlled doses of ketamine are administered intravenously to individuals grappling with severe depression and anxiety. The rationale behind this unconventional use stems from the drug's ability to rapidly alleviate symptoms in some patients, offering a potential breakthrough in the treatment of mood disorders that are often resistant to conventional therapies.</p>

<p>As per the medical examiner's report, the levels of ketamine in Perry's body were not consistent with those expected during routine ketamine infusion therapy sessions. Instead, the concentrations were akin to the levels utilised for general anesthesia in the context of surgical procedures.&nbsp;</p>

<p><iframe allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/FWegGF47rik?si=MOdZQLdxX15FqJ2q" title="YouTube video player" width="560"></iframe></p>

<p>Crucially, as per an Associated Press report, the last ketamine infusion therapy session Perry underwent, occurring one and a half weeks before his death, did not align with the persistently elevated ketamine levels found in his body. The drug is typically metabolised and eliminated from the body within a matter of hours.&nbsp;</p>

<h2><strong>How does ketamine work as an anesthetic and as an anti-depressant and anxiolytic (anti-anxiety drug)?</strong></h2>

<p>Ketamine acts primarily as an N-methyl-D-aspartate (NMDA) receptor antagonist, blocking the action of glutamate, a neurotransmitter involved in synaptic transmission. Its effects on the central nervous system lead to dissociation, analgesia, and, in some instances, psychedelic experiences. The rapid onset and short duration of action have contributed to its popularity in medical settings.</p>

<p>In the context of ketamine infusion therapy, the drug is administered at sub-anesthetic doses, often in a series of sessions over a prescribed period. This controlled exposure is believed to modulate neural pathways and receptor functions, potentially providing relief to individuals grappling with treatment-resistant depression and anxiety. The exact mechanisms underlying ketamine's antidepressant effects are not yet fully understood, but it is thought to involve complex interactions with various neurotransmitter systems and synaptic plasticity.<br />
&nbsp;</p>


Matthew Perry's cause of death has been disclosed as stemming from the acute effects of ketamine, a potent anesthetic that has found diverse applications in both medical and experimental psychiatric treatments.

Matthew Perry's cause of death has been disclosed as stemming from the acute effects of ketamine, a potent anesthetic that has found diverse applications in both medical and experimental psychiatric treatments. Perry, widely known for his role as Chandler Bing in the iconic television series Friends, was undergoing ketamine infusion therapy — a procedure intended to address severe depression and anxiety. The revelation from the medical examiner's report has brought to light the specific circumstances surrounding Perry's tragic demise. What is Ketamine? Ketamine, chemically classified as a dissociative anesthetic, has long been employed in medical settings for inducing and maintaining anesthesia during surgical procedures. Its ability to produce sedation, analgesia, and dissociation from the surrounding environment has made it a valuable tool in various medical contexts. However, the past decade has witnessed an expansion of its use beyond its traditional role, particularly in the field of mental health. Also Read | Matthew Perry's cause of death revealed Ketamine infusion therapy Ketamine infusion therapy represents one such off-label application, where controlled doses of ketamine are administered intravenously to individuals grappling with severe depression and anxiety. The rationale behind this unconventional use stems from the drug's ability to rapidly alleviate symptoms in some patients, offering a potential breakthrough in the treatment of mood disorders that are often resistant to conventional therapies. As per the medical examiner's report, the levels of ketamine in Perry's body were not consistent with those expected during routine ketamine infusion therapy sessions. Instead, the concentrations were akin to the levels utilised for general anesthesia in the context of surgical procedures. Crucially, as per an Associated Press report, the last ketamine infusion therapy session Perry underwent, occurring one and a half weeks before his death, did not align with the persistently elevated ketamine levels found in his body. The drug is typically metabolised and eliminated from the body within a matter of hours. How does ketamine work as an anesthetic and as an anti-depressant and anxiolytic (anti-anxiety drug)? Ketamine acts primarily as an N-methyl-D-aspartate (NMDA) receptor antagonist, blocking the action of glutamate, a neurotransmitter involved in synaptic transmission. Its effects on the central nervous system lead to dissociation, analgesia, and, in some instances, psychedelic experiences. The rapid onset and short duration of action have contributed to its popularity in medical settings. In the context of ketamine infusion therapy, the drug is administered at sub-anesthetic doses, often in a series of sessions over a prescribed period. This controlled exposure is believed to modulate neural pathways and receptor functions, potentially providing relief to individuals grappling with treatment-resistant depression and anxiety. The exact mechanisms underlying ketamine's antidepressant effects are not yet fully understood, but it is thought to involve complex interactions with various neurotransmitter systems and synaptic plasticity.

Unravelling ketamine: The drug linked to actor Matthew Perry's death

<p>The Los Angeles County Medical Examiner's Office recently released the toxicology report on the late Matthew Perry, unveiling the cause of the beloved actor's death. Perry, best known for his role as Chandler Bing in&nbsp;<em>Friends</em>, passed away on October 28, 2023. The report indicates that the actor succumbed to the acute effects of ketamine, a potent anaesthetic often used in medical and recreational settings, as per <em>Variety</em>.</p>

<p>Perry had been undergoing ketamine infusion therapy as part of his treatment for depression and anxiety. This therapeutic approach involves the controlled administration of ketamine, but the exact method of intake leading to the fatal overdose remains undisclosed. The toxicology report notes that the high levels of ketamine found in Perry's postmortem blood specimens would have led to cardiovascular overstimulation and respiratory depression, ultimately resulting in his untimely demise.</p>

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<p>In addition to the ketamine overdose, the report identified other contributing factors to Perry's death. These included drowning, coronary artery disease, and the effects of buprenorphine, a medication commonly used to treat opioid use disorder. The combined impact of these factors led authorities to rule the death as an accident.</p>

<p>Authorities discovered Perry in a hot tub at his Los Angeles home around 4 pm on the day of his death. First responders were called for a cardiac arrest, with no signs of foul play or drugs at the scene. The circumstances surrounding Perry's passing, while tragic, were not deemed suspicious.</p>

<p>Perry's <em>Friends </em>co-stars, Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc, and David Schwimmer, expressed their profound sadness at the loss. In a joint statement, they described the actor as more than just a cast mate, saying they had a familial bond with him. Aniston recently mentioned that she had exchanged texts with Perry on the morning of his death and described him as happy and healthy.<br />
&nbsp;</p>


The Los Angeles County Medical Examiner's Office recently released the toxicology report on the late Matthew Perry, unveiling the cause of the beloved actor's death.

The Los Angeles County Medical Examiner's Office recently released the toxicology report on the late Matthew Perry, unveiling the cause of the beloved actor's death. Perry, best known for his role as Chandler Bing in Friends, passed away on October 28, 2023. The report indicates that the actor succumbed to the acute effects of ketamine, a potent anaesthetic often used in medical and recreational settings, as per Variety. Perry had been undergoing ketamine infusion therapy as part of his treatment for depression and anxiety. This therapeutic approach involves the controlled administration of ketamine, but the exact method of intake leading to the fatal overdose remains undisclosed. The toxicology report notes that the high levels of ketamine found in Perry's postmortem blood specimens would have led to cardiovascular overstimulation and respiratory depression, ultimately resulting in his untimely demise. In addition to the ketamine overdose, the report identified other contributing factors to Perry's death. These included drowning, coronary artery disease, and the effects of buprenorphine, a medication commonly used to treat opioid use disorder. The combined impact of these factors led authorities to rule the death as an accident. Authorities discovered Perry in a hot tub at his Los Angeles home around 4 pm on the day of his death. First responders were called for a cardiac arrest, with no signs of foul play or drugs at the scene. The circumstances surrounding Perry's passing, while tragic, were not deemed suspicious. Perry's Friends co-stars, Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc, and David Schwimmer, expressed their profound sadness at the loss. In a joint statement, they described the actor as more than just a cast mate, saying they had a familial bond with him. Aniston recently mentioned that she had exchanged texts with Perry on the morning of his death and described him as happy and healthy.

Actor Matthew Perry's cause of death revealed in toxicology report as Ketamine poisoning

<p>The recent passing of Matthew Perry, beloved for his portrayal of Chandler Bing on the iconic TV series <em>Friends</em>, has left a void in the hearts of fans worldwide. As the news of his passing spread, an overwhelming sense of grief and loss gripped the legions of <em>Friends </em>enthusiasts, who were now collectively mourning the loss of one of the show's iconic stars.&nbsp;</p>

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<p>In a poignant and heartfelt tribute, Matt LeBlanc, who brought the character of Joey Tribbiani to life in the show, has shared his emotions and memories of the cherished moments spent with Perry.</p>

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<p>In a post on Instagram, LeBlanc, 56, conveyed the profound impact of Perry's friendship. "It was an honour to call you my friend. It is with a heavy heart I say goodbye. I'll never forget you," wrote LeBlanc.</p>

<p>Also Read |&nbsp;<strong><a href="https://www.wionews.com/entertainment/hollywood/news-zac-efron-hugely-honoured-to-potentially-play-matthew-perry-in-biopic-656957">Zac Efron 'hugely honoured' to potentially play Matthew Perry in biopic</a></strong></p>

<p>Accompanying LeBlanc's words were a series of pictures capturing candid moments shared on the set of <em>Friends</em>. "The times we had together are honestly among the favorite times of my life. It was an honor to share the stage with you and to call you my friend," Le Blanc shared, providing fans with a visual journey through the laughter and camaraderie that defined their friendship.</p>

<p>LeBlanc's tribute continued, "I will always smile when I think of you, and I'll never forget you. Never. Spread your wings and fly, brother; you're finally free."&nbsp;</p>


The recent passing of Matthew Perry, beloved for his portrayal of Chandler Bing on the iconic TV series Friends, has left a void in the hearts of fans worldwide.

The recent passing of Matthew Perry, beloved for his portrayal of Chandler Bing on the iconic TV series Friends, has left a void in the hearts of fans worldwide. As the news of his passing spread, an overwhelming sense of grief and loss gripped the legions of Friends enthusiasts, who were now collectively mourning the loss of one of the show's iconic stars. View this post on Instagram A post shared by Matt LeBlanc (@mleblanc) In a poignant and heartfelt tribute, Matt LeBlanc, who brought the character of Joey Tribbiani to life in the show, has shared his emotions and memories of the cherished moments spent with Perry. In a post on Instagram, LeBlanc, 56, conveyed the profound impact of Perry's friendship. "It was an honour to call you my friend. It is with a heavy heart I say goodbye. I'll never forget you," wrote LeBlanc. Also Read | Zac Efron 'hugely honoured' to potentially play Matthew Perry in biopic Accompanying LeBlanc's words were a series of pictures capturing candid moments shared on the set of Friends. "The times we had together are honestly among the favorite times of my life. It was an honor to share the stage with you and to call you my friend," Le Blanc shared, providing fans with a visual journey through the laughter and camaraderie that defined their friendship. LeBlanc's tribute continued, "I will always smile when I think of you, and I'll never forget you. Never. Spread your wings and fly, brother; you're finally free."

I'll always smile when I think of you: Matt LeBlanc's emotional tribute to Matthew Perry

<p>The world was met with heart-wrenching news on Saturday, October 28 as it learned of the passing of Matthew Perry, a beloved actor whose portrayal of Chandler Bing on the hit TV show <em>Friends</em> left an enduring mark on the hearts of fans around the globe.&nbsp;As the news of his passing spread, an overwhelming sense of grief and loss has gripped the legions of <em>Friends</em> enthusiasts, who are now collectively mourning the loss of one of the show's iconic stars.&nbsp;</p>

<p>Reflecting on <em>Friends</em> and the beloved actor, former WBTV comedy boss David Janollari shared some intimate details about the casting process that brought Chandler Bing to life on screen. In a column he penned for <em>The Hollywood Reporter,</em> he expressed, "Casting the six Friends, along with creators Marta Kauffman, David Crane, and Kevin Bright, was challenging. They all had to be 'stars.' The chemistry had to be believable. You just had to love them. And no one was more elusive than Chandler."</p>

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<p>With only two roles left to cast just days before production on the pilot, he recalled a pivotal moment during a CBS pilot run-through that changed the course of the show's history. He described how Matthew Perry, who was a guest star in the struggling CBS pilot, stood out and "literally stole the show." This unexpected discovery led Janollari to consider Perry for the role of Chandler.</p>

<p>Janollari vividly recounted the moment when the decision was made, saying, "Then we turned our attention back to the run-through, and like that a-ha moment in a movie that you really don't believe happens in real life, we both turned to each other with eyes wide open and said at the same time, 'Chandler!'" It was a serendipitous turning point in the casting process.</p>

<p>Also Read |&nbsp;<strong><a href="https://www.wionews.com/entertainment/hollywood/news-hank-azaria-pays-emotional-tribute-to-matthew-perry-credits-him-for-sobriety-he-was-so-caring-653499">Hank Azaria pays emotional tribute to Matthew Perry, credits him for helping get sober: He was so caring</a></strong></p>

<p>However, Janollari also noted that Matthew Perry hadn't initially auditioned for the role of Chandler because he was under contract for a Fox pilot at the time. To secure Perry for Friends, Janollari had to navigate the complexities of the industry. He called a friend at Fox, who advised them to hire Perry for the second position. This move allowed Perry to read for Chandler, and as Janollari fondly recalled, "the rest is history. It was magic." It was indeed magic, as Perry's portrayal of Chandler Bing became an integral part of the show's success.</p>

<p><strong>WATCH WION LIVE HERE</strong></p>

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<p>&nbsp;</p>


The world was met with heart-wrenching news on Saturday, October 28 as it learned of the passing of Matthew Perry, a beloved actor whose portrayal of Chandler Bing on the hit TV show Friends left an enduring mark on the hearts of fans around the globe.

The world was met with heart-wrenching news on Saturday, October 28 as it learned of the passing of Matthew Perry, a beloved actor whose portrayal of Chandler Bing on the hit TV show Friends left an enduring mark on the hearts of fans around the globe. As the news of his passing spread, an overwhelming sense of grief and loss has gripped the legions of Friends enthusiasts, who are now collectively mourning the loss of one of the show's iconic stars. Reflecting on Friends and the beloved actor, former WBTV comedy boss David Janollari shared some intimate details about the casting process that brought Chandler Bing to life on screen. In a column he penned for The Hollywood Reporter, he expressed, "Casting the six Friends, along with creators Marta Kauffman, David Crane, and Kevin Bright, was challenging. They all had to be 'stars.' The chemistry had to be believable. You just had to love them. And no one was more elusive than Chandler." With only two roles left to cast just days before production on the pilot, he recalled a pivotal moment during a CBS pilot run-through that changed the course of the show's history. He described how Matthew Perry, who was a guest star in the struggling CBS pilot, stood out and "literally stole the show." This unexpected discovery led Janollari to consider Perry for the role of Chandler. Janollari vividly recounted the moment when the decision was made, saying, "Then we turned our attention back to the run-through, and like that a-ha moment in a movie that you really don't believe happens in real life, we both turned to each other with eyes wide open and said at the same time, 'Chandler!'" It was a serendipitous turning point in the casting process. Also Read | Hank Azaria pays emotional tribute to Matthew Perry, credits him for helping get sober: He was so caring However, Janollari also noted that Matthew Perry hadn't initially auditioned for the role of Chandler because he was under contract for a Fox pilot at the time. To secure Perry for Friends, Janollari had to navigate the complexities of the industry. He called a friend at Fox, who advised them to hire Perry for the second position. This move allowed Perry to read for Chandler, and as Janollari fondly recalled, "the rest is history. It was magic." It was indeed magic, as Perry's portrayal of Chandler Bing became an integral part of the show's success. WATCH WION LIVE HERE

'It was magic': Matthew Perry's serendipitous casting as Chandler Bing in Friends

<p>Late actor Matthew Perry, who had for years struggled with addiction, had planned to build a foundation for those battling substance abuse.&nbsp;<br />
<br />
He had earlier founded Perry House, a men’s sober living facility which operated from the actor's Malibu home. It ran for two years before hitting financial constraints.<br />
<br />
During his life, Perry had a long struggle with addiction. He later also opened up about his subsequent journey to sobriety and was a strong advocate of helping others cope with addiction. He revealed in October 2022 that he almost died at 49 due to his increasing drug addiction, and was in a coma for two weeks, fighting for his life. This was followed by a stay in the hospital for five months, as well as a year using a colostomy bag after his colon burst due to opioid overuse.<br />
<br />
Meanwhile, sources who were in touch with Perry told TMZ that he had "never been happier" before his death. The <em>Friends</em> star had only just moved into his new house three weeks ago and was enjoying his current phase in life.&nbsp;<br />
<br />
Sources also told the news outlet that Perry recently committed to acting in a new movie as well as other projects. He had also been coming up with ideas for scripts, and his life appeared to be optimistic.&nbsp;<br />
<br />
<strong>Matthew Perry was found dead in his hot tub</strong><br />
<br />
News details related to Perry's death have revealed that the actor was found underwater in his hot tub by his assistant&nbsp;who lifted up his head and tried to get him some air, first responders told the Daily Mail. By the time the Los Angeles Fire Department arrived at the actor’s house and pulled him out of the jacuzzi, he was already dead. The actor died of drowning in his hot tub at his LA home.<br />
<br />
The Los Angeles County Medical Examiner's Office stated that an autopsy has been completed but toxicology reports are pending. The status of Perry’s cause of death is now listed as "deferred" since it is "pending additional investigation." The authorities have ruled out foul play in the case.&nbsp;<br />
<br />
<br />
<br />
<em><strong>WATCH WION LIVE HERE</strong></em></p>

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Late actor Matthew Perry, who had for years struggled with addiction, had planned to build a foundation for those battling substance abuse. He had earlier founded Perry House, a men’s sober living facility which operated from the actor's Malibu home.

Late actor Matthew Perry, who had for years struggled with addiction, had planned to build a foundation for those battling substance abuse. He had earlier founded Perry House, a men’s sober living facility which operated from the actor's Malibu home. It ran for two years before hitting financial constraints. During his life, Perry had a long struggle with addiction. He later also opened up about his subsequent journey to sobriety and was a strong advocate of helping others cope with addiction. He revealed in October 2022 that he almost died at 49 due to his increasing drug addiction, and was in a coma for two weeks, fighting for his life. This was followed by a stay in the hospital for five months, as well as a year using a colostomy bag after his colon burst due to opioid overuse. Meanwhile, sources who were in touch with Perry told TMZ that he had "never been happier" before his death. The Friends star had only just moved into his new house three weeks ago and was enjoying his current phase in life. Sources also told the news outlet that Perry recently committed to acting in a new movie as well as other projects. He had also been coming up with ideas for scripts, and his life appeared to be optimistic. Matthew Perry was found dead in his hot tub News details related to Perry's death have revealed that the actor was found underwater in his hot tub by his assistant who lifted up his head and tried to get him some air, first responders told the Daily Mail. By the time the Los Angeles Fire Department arrived at the actor’s house and pulled him out of the jacuzzi, he was already dead. The actor died of drowning in his hot tub at his LA home. The Los Angeles County Medical Examiner's Office stated that an autopsy has been completed but toxicology reports are pending. The status of Perry’s cause of death is now listed as "deferred" since it is "pending additional investigation." The authorities have ruled out foul play in the case. WATCH WION LIVE HERE

Matthew Perry planned to open a facility for those struggling with substance abuse

<p>Actor-comedian Hank Azaria recently shared a heartfelt video tribute to his late close friend and fellow actor, Matthew Perry. Azaria, who essayed the role of David in <em>Friends</em>, credited Perry with playing a crucial role in helping him maintain sobriety. The two actors met during their early careers and shared a profound friendship, which endured both the joys and trials of show business.</p>

<p>Their friendship began when Azaria and Perry worked together on the pilot of <em>Morning Maggie</em>. At the time, Azaria was 21, while Perry was just 16, but their age difference didn't deter the growth of their friendship. They became like brothers, navigating the entertainment industry's ups and downs together.</p>

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<p>“The night I went into AA, Matthew brought me in. The whole first year I was sober, we went to meetings together… I got to tell him this, as a sober person, he was so caring and giving and wise, and he totally helped me get sober. And, I really wish he could’ve found it in himself to stay with the sober life more consistently.”&nbsp;</p>

<p>Azaria fondly reminisced about the days when he and Perry would enjoy laughter and drinks together. Despite the fun they had, both actors faced their own personal battles. Perry openly discussed his ongoing struggle with substance abuse in his autobiography, titled<em> Friends, Lovers, and the Big Terrible Thing: A Memoir.&nbsp;</em></p>

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<p>Added Azaria, "But it’s heartbreaking, for those of us who loved him and knew him really well, personally. We just missed him. We just missed him. It’s one of the terrible things about this disease, is it just takes away the person you love.”</p>

<p>“As an actor, he was so brilliant. I just wish we – the world — I and the world — could have gotten what the rest of his career would’ve been," concluded Azaria.<br />
<br />
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<p><strong>WATCH WION LIVE HERE</strong></p>

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Actor-comedian Hank Azaria recently shared a heartfelt video tribute to his late close friend and fellow actor, Matthew Perry. Azaria, who essayed the role of David in Friends, credited Perry with playing a crucial role in helping him maintain sobriety.

Actor-comedian Hank Azaria recently shared a heartfelt video tribute to his late close friend and fellow actor, Matthew Perry. Azaria, who essayed the role of David in Friends, credited Perry with playing a crucial role in helping him maintain sobriety. The two actors met during their early careers and shared a profound friendship, which endured both the joys and trials of show business. Their friendship began when Azaria and Perry worked together on the pilot of Morning Maggie. At the time, Azaria was 21, while Perry was just 16, but their age difference didn't deter the growth of their friendship. They became like brothers, navigating the entertainment industry's ups and downs together. View this post on Instagram A post shared by Hank Azaria (@hankazaria) × “The night I went into AA, Matthew brought me in. The whole first year I was sober, we went to meetings together… I got to tell him this, as a sober person, he was so caring and giving and wise, and he totally helped me get sober. And, I really wish he could’ve found it in himself to stay with the sober life more consistently.” Azaria fondly reminisced about the days when he and Perry would enjoy laughter and drinks together. Despite the fun they had, both actors faced their own personal battles. Perry openly discussed his ongoing struggle with substance abuse in his autobiography, titled Friends, Lovers, and the Big Terrible Thing: A Memoir. Added Azaria, "But it’s heartbreaking, for those of us who loved him and knew him really well, personally. We just missed him. We just missed him. It’s one of the terrible things about this disease, is it just takes away the person you love.” “As an actor, he was so brilliant. I just wish we – the world — I and the world — could have gotten what the rest of his career would’ve been," concluded Azaria. WATCH WION LIVE HERE

Hank Azaria pays emotional tribute to Matthew Perry, credits him for helping get sober: He was so caring