Vultures in Southeast Asia including India face a steep decline in their population prompting researchers across the Indian subcontinent to trace back to the source of the problem. A new study has found that vultures are dying due to fatal poisoning from feeding on livestock carcasses and a drug to blame. Scientists have found that Diclofenac is behind the deaths and rapid deterioration of India's vulture population.

Drug for cattle kills vultures?

One of the most reliable medications for easing pain is paracetamol. These tablets provide hassle-free, immediate relief that has been shown to be effective for decades. However, professionals have cautioned those who frequently take paracetamol about grave health risks.

A team at the University of Edinburgh conducted a recent study in which they evaluated the effects of the medicine on mice and came to the conclusion that it damages living things. The result, according to the scientists, may guide future studies into treatments intended to offset the negative effects of the medicine.

Also read:&nbsp;<a data-ctorig="https://www.wionews.com/science/does-paracetamols-use-pose-any-risk-study-makes-the-striking-revelation-451403" data-cturl="https://www.google.com/url?client=internal-element-cse&amp;cx=006054055338965708568:09spwrlibei&amp;q=https://www.wionews.com/science/does-paracetamols-use-pose-any-risk-study-makes-the-striking-revelation-451403&amp;sa=U&amp;ved=2ahUKEwiXkOvfj7qEAxVKl1YBHQvJB8oQFnoECAAQAg&amp;usg=AOvVaw1T7228BOFkArAIBaAAKnR9" dir="ltr" href="https://www.wionews.com/science/does-paracetamols-use-pose-any-risk-study-makes-the-striking-revelation-451403" target="_blank">Does&nbsp;paracetamol's&nbsp;use pose any risk?</a>

Researchers cautioned that patients who use an excessive amount of the medication may have severe side effects. For individuals with persistent pain, a typical dosage of paracetamol is four grams per day.

"Scientists at the University of Edinburgh studied the impact of paracetamol on liver cells in human and mouse tissue, and tests showed that in certain settings paracetamol can damage the liver by harming vital structural connections between adjacent cells in the organ," the study said.

According to the research, ‘paracetamol’ can damage the liver in specific situations by damaging key structural connections between adjacent cells in the organ, which was investigated by researchers at the University of Edinburgh on the effects of the drug on liver cells in human and mouse tissue.

When the liver's tissue structure is harmed, cells become dysfunctional and may even die, according to the statement that follows. "These cell wall connections, known as tight junctions," are what cause the damage.

This work represents the first to connect liver damage, like to that observed in diseases like cancer, cirrhosis, and hepatitis, with paracetamol toxicity.

The study was published in the journal Scientific Reports and involved researchers from the Scottish National Blood Transfusion Service, the <a href="https://www.ed.ac.uk/research-innovation/animal-research/news/paracetamol-study-sheds-light-on-liver-damage">Universities of Edinburgh</a> and Oslo.

(With inputs from agencies)

One of the most reliable medications for easing pain is paracetamol. These tablets provide hassle-free, immediate relief that has been shown to be effective for decades.

One of the most reliable medications for easing pain is paracetamol. These tablets provide hassle-free, immediate relief that has been shown to be effective for decades. However, professionals have cautioned those who frequently take paracetamol about grave health risks. A team at the University of Edinburgh conducted a recent study in which they evaluated the effects of the medicine on mice and came to the conclusion that it damages living things. The result, according to the scientists, may guide future studies into treatments intended to offset the negative effects of the medicine. Also read: Does paracetamol's use pose any risk? Researchers cautioned that patients who use an excessive amount of the medication may have severe side effects. For individuals with persistent pain, a typical dosage of paracetamol is four grams per day. "Scientists at the University of Edinburgh studied the impact of paracetamol on liver cells in human and mouse tissue, and tests showed that in certain settings paracetamol can damage the liver by harming vital structural connections between adjacent cells in the organ," the study said. According to the research, ‘paracetamol’ can damage the liver in specific situations by damaging key structural connections between adjacent cells in the organ, which was investigated by researchers at the University of Edinburgh on the effects of the drug on liver cells in human and mouse tissue. When the liver's tissue structure is harmed, cells become dysfunctional and may even die, according to the statement that follows. "These cell wall connections, known as tight junctions," are what cause the damage. This work represents the first to connect liver damage, like to that observed in diseases like cancer, cirrhosis, and hepatitis, with paracetamol toxicity. The study was published in the journal Scientific Reports and involved researchers from the Scottish National Blood Transfusion Service, the Universities of Edinburgh and Oslo. (With inputs from agencies)

Study shows how paracetamol, a common painkiller, may affect the liver

The common painkiller, mefenamic acid, has been linked to severe allergic reactions including the DRESS syndrome, which affects internal organs, according to a drug safety advisory issued by the Indian Pharmacopoeia Commission (IPC).

Gravitas: Alert issued against common Indian painkillers Government alerts on Meftal

The Indian Pharmacopoeia Commission (IPC) has issued a drug safety alert regarding the Meftal painkiller, saying the pill has&nbsp;adverse reactions associated with its constituent, mefenamic acid. The alert specifically mentions the risk of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome.

Meftal, containing mefenamic acid, is commonly prescribed for various conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhoea, mild to moderate pain, inflammation, fever, and dental pain.

DRESS syndrome is a severe allergic reaction linked to certain medications, with symptoms such as skin rash, fever, and lymphadenopathy appearing between two and eight weeks after drug intake.

"Healthcare professionals, patients/consumers are advised to closely monitor the possibility of the above adverse drug reaction (ADR) associated with the use of the suspected drug," according to the alert, issued on November 30.

<a href="https://www.wionews.com/world/japan-approves-medical-cannabis-use-toughens-recreational-marijuana-ban-in-landmark-drug-law-revision-667218">Also read |&nbsp;Japan approves medical cannabis use, toughens recreational marijuana ban in landmark drug law revision</a>

<h2>What's the cautionary advice?</h2>

Healthcare professionals and patients are strongly advised to closely monitor the possibility of the mentioned adverse drug reaction associated with Meftal usage.

Also watch |&nbsp;Gravitas Plus: Unlocking the power of Traditional Medicine

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"If such a reaction is encountered, people should report the matter to the national coordination centre of the PvPI under the commission by filing a form on the website - www.ipc.gov.in - or through android mobile app ADR PvPI and PvPI helpline number 1800-180-3024," the release stated.

<a href="https://www.wionews.com/india-news/india-bans-14-fixed-dose-combination-drugs-including-nimesulide-and-paracetamol-report-600393">Also read |&nbsp;India bans 14 fixed-dose combination drugs including nimesulide and paracetamol: Report</a>

The IPC urges vigilance for symptoms indicative of DRESS syndrome. In case such reactions are observed, individuals are encouraged to promptly report the matter to the national coordination centre of the PvPI. Reporting can be done through the IPC's official website (<a href="http://www.ipc.gov.in/" target="_new">www.ipc.gov.in</a>), the android mobile app ADR PvPI, or the PvPI helpline number 1800-180-3024.

(With inputs from agencies)

&nbsp;

The Indian Pharmacopoeia Commission (IPC) has issued a drug safety alert regarding the Meftal painkiller, saying the pill has adverse reactions associated with its constituent, mefenamic acid.

The Indian Pharmacopoeia Commission (IPC) has issued a drug safety alert regarding the Meftal painkiller, saying the pill has adverse reactions associated with its constituent, mefenamic acid. The alert specifically mentions the risk of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome. Meftal, containing mefenamic acid, is commonly prescribed for various conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhoea, mild to moderate pain, inflammation, fever, and dental pain. DRESS syndrome is a severe allergic reaction linked to certain medications, with symptoms such as skin rash, fever, and lymphadenopathy appearing between two and eight weeks after drug intake. "Healthcare professionals, patients/consumers are advised to closely monitor the possibility of the above adverse drug reaction (ADR) associated with the use of the suspected drug," according to the alert, issued on November 30. Also read | Japan approves medical cannabis use, toughens recreational marijuana ban in landmark drug law revision What's the cautionary advice? Healthcare professionals and patients are strongly advised to closely monitor the possibility of the mentioned adverse drug reaction associated with Meftal usage. Also watch | Gravitas Plus: Unlocking the power of Traditional Medicine "If such a reaction is encountered, people should report the matter to the national coordination centre of the PvPI under the commission by filing a form on the website - www.ipc.gov.in - or through android mobile app ADR PvPI and PvPI helpline number 1800-180-3024," the release stated. Also read | India bans 14 fixed-dose combination drugs including nimesulide and paracetamol: Report The IPC urges vigilance for symptoms indicative of DRESS syndrome. In case such reactions are observed, individuals are encouraged to promptly report the matter to the national coordination centre of the PvPI. Reporting can be done through the IPC's official website (www.ipc.gov.in), the android mobile app ADR PvPI, or the PvPI helpline number 1800-180-3024. (With inputs from agencies)

Taking painkiller Meftal casually? Indian government says it can cause adverse reactions

Dolo-maker Micro Labs Ltd. has been charged by the Central Board of Direct Taxes (CBDT) with engaging in "unethical practises" and providing doctors and other medical professionals with free gifts worth roughly USD 125 million (INR 1,000&nbsp;crore) in exchange for endorsing the company's products. PTI reports that the claims follow&nbsp;a raid on 36 Micro Labs Ltd. located across nine states by the Income Tax authorities on July 6 and that although the group was not named in the CBDT statement, sources revealed it was Micro Labs.&nbsp;CBDT said in a statement that following the action against the Bengaluru-based pharma company, the agency seized "unaccounted" cash totalling $150,000&nbsp;(INR 1.20 crore) and gold and diamond jewellery worth $175,000 (INR 1.40 crore).&nbsp;

Watch |&nbsp;Gravitas: Rupee's historic plunge, breaches 80 against dollar

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"The initial gleaning of the evidence has revealed that the group has been debiting in its books of account unallowable expenses on account of the distribution of freebies to the medical professionals under the head 'sales and promotion'," said the Indian I-T department's administrative body.

"During the course of the search operations, substantial incriminating evidence, in the form of documents and digital data, has been found and seized."

Also read |&nbsp;<a href="https://www.wionews.com/trending/how-made-in-india-pill-dolo-650-became-indias-favourite-snack-in-covid-waves-445350">How made-in-India pill Dolo 650 became India’s ‘favourite snack’ in Covid waves</a>

The CBDT also accused the firm of other irregularities.&nbsp;

"Various other means of tax evasion, including inadequate allocation of research and development expenses to eligible units and inflated claim of weighted deduction under section 35 (2AB), have also been detected," the CBDT said.

Reportedly, the department also discovered instances of "violation" of the tax deduction at source (TDS) rules under section 194C of the I-T Act.

Dolo-650 is an oral tablet that is both an analgesic (used to treat pain) and an antipyretic (used to treat fever) that doctors and medical store owners frequently give to coronavirus patients to treat their typical symptoms of pain and fever.

(With inputs from agencies)

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Dolo-maker Micro Labs Ltd. has been charged by the Central Board of Direct Taxes (CBDT) with engaging in "unethical practises" and providing doctors and other medical professionals with free gifts worth roughly USD 125 million (INR 1,000 crore) in exchange for endorsing the company's products.

Dolo-maker Micro Labs Ltd. has been charged by the Central Board of Direct Taxes (CBDT) with engaging in "unethical practises" and providing doctors and other medical professionals with free gifts worth roughly USD 125 million (INR 1,000 crore) in exchange for endorsing the company's products. PTI reports that the claims follow a raid on 36 Micro Labs Ltd. located across nine states by the Income Tax authorities on July 6 and that although the group was not named in the CBDT statement, sources revealed it was Micro Labs. CBDT said in a statement that following the action against the Bengaluru-based pharma company, the agency seized "unaccounted" cash totalling $150,000 (INR 1.20 crore) and gold and diamond jewellery worth $175,000 (INR 1.40 crore). Watch | Gravitas: Rupee's historic plunge, breaches 80 against dollar "The initial gleaning of the evidence has revealed that the group has been debiting in its books of account unallowable expenses on account of the distribution of freebies to the medical professionals under the head 'sales and promotion'," said the Indian I-T department's administrative body. "During the course of the search operations, substantial incriminating evidence, in the form of documents and digital data, has been found and seized." Also read | How made-in-India pill Dolo 650 became India’s ‘favourite snack’ in Covid waves The CBDT also accused the firm of other irregularities. "Various other means of tax evasion, including inadequate allocation of research and development expenses to eligible units and inflated claim of weighted deduction under section 35 (2AB), have also been detected," the CBDT said. Reportedly, the department also discovered instances of "violation" of the tax deduction at source (TDS) rules under section 194C of the I-T Act. Dolo-650 is an oral tablet that is both an analgesic (used to treat pain) and an antipyretic (used to treat fever) that doctors and medical store owners frequently give to coronavirus patients to treat their typical symptoms of pain and fever. (With inputs from agencies) Watch WION LIVE HERE: You can now write for wionews.com and be a part of the community. Share your stories and opinions with us here.

Revealed: How Dolo-650 became India's favourite painkiller - 'gifts' worth millions

Last year, a record 100,000 people in the US lost their lives to this epidemic. Not Covid, this self-afflicted disease is more sinister. "Painkiller addiction"....

'Painkiller addiction': An epidemic affecting millions in the US

Music superstar&nbsp;Prince, who was found dead in his home in a Minneapolis suburb in late April,&nbsp;died&nbsp;of an&nbsp;accidental, self-administered&nbsp;overdose&nbsp;of an opioid painkiller, the county&nbsp;medical&nbsp;examiner&nbsp;said in a death report on Thursday.

The Midwest&nbsp;Medical&nbsp;Examiner&#39;s Office in Anoka County, Minnesota, had been investigating the 57-year-old&nbsp;singer&#39;s death since he was discovered in an elevator in his home and studio on April 21.

&quot;The decedent self-administered fentanyl,&quot; the&nbsp;medical&nbsp;examiner&#39;s report said,&nbsp;listing cause of death as &quot;fentanyl toxicity&quot;, and noting it was&nbsp;accidental.

The investigation into&nbsp;Prince&#39;s death has centered on&nbsp;painkillers after prescription opioid medication was found at the scene and after reports he had been struggling with an addiction and had been scheduled to meet with a doctor who specializes in treating dependency.

Fentanyl is a highly addictive opiate that is more powerful than morphine and is used to treat patients with severe pain, often after surgeries. It took weeks for officials to release the cause of death because they were waiting for the results of toxicity tests.

The Minneapolis Star Tribune said it was not clear whether fentanyl had been prescribed to Prince&nbsp;and if so, which doctor prescribed it.

Fentanyl is often sold illegally and the U.S. Centers for Disease Control has said that rising drug overdose&nbsp;deaths in the United States are linked to increased use of illicitly manufactured fentanyl.

The local prosecutor, Carver County Attorney Mark Metz, said the county sheriff&#39;s office continues to investigate&nbsp;Prince&#39;s death, assisted by federal authorities, but at this point has not handed over the results of the probe to prosecutors.

&quot;They will be looking at many different things,&quot; Metz told Reuters by telephone.

Prince, whose full name was&nbsp;Prince&nbsp;Rogers Nelson, did not leave a will, and his multimillion-dollar estate including royalties from his more than 30 albums is being handled by a court. The songwriter&#39;s hits include &quot;Purple Rain&quot; and &quot;When Doves Cry.&quot;

Music superstar?Prince, who was found dead in late April,?died?of an?accidental, self-administered?overdose?of an opioid painkiller, the county?medical?examiner?said in a death report on Thursday

Music superstar Prince, who was found dead in his home in a Minneapolis suburb in late April, died of an accidental, self-administered overdose of an opioid painkiller, the county medical examiner said in a death report on Thursday. The Midwest Medical Examiner's Office in Anoka County, Minnesota, had been investigating the 57-year-old singer's death since he was discovered in an elevator in his home and studio on April 21. "The decedent self-administered fentanyl," the medical examiner's report said, listing cause of death as "fentanyl toxicity", and noting it was accidental. The investigation into Prince's death has centered on painkillers after prescription opioid medication was found at the scene and after reports he had been struggling with an addiction and had been scheduled to meet with a doctor who specializes in treating dependency. Fentanyl is a highly addictive opiate that is more powerful than morphine and is used to treat patients with severe pain, often after surgeries. It took weeks for officials to release the cause of death because they were waiting for the results of toxicity tests. The Minneapolis Star Tribune said it was not clear whether fentanyl had been prescribed to Prince and if so, which doctor prescribed it. Fentanyl is often sold illegally and the U.S. Centers for Disease Control has said that rising drug overdose deaths in the United States are linked to increased use of illicitly manufactured fentanyl. The local prosecutor, Carver County Attorney Mark Metz, said the county sheriff's office continues to investigate Prince's death, assisted by federal authorities, but at this point has not handed over the results of the probe to prosecutors. "They will be looking at many different things," Metz told Reuters by telephone. Prince, whose full name was Prince Rogers Nelson, did not leave a will, and his multimillion-dollar estate including royalties from his more than 30 albums is being handled by a court. The songwriter's hits include "Purple Rain" and "When Doves Cry."

Singer Prince died of accidental painkiller overdose: Medical examiner

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