No one has escaped from the 'Supermax' prison since it opened in 1994, and Guzman would join a long list of the most infamous of criminals who call it home.
Joaquin Guzman, the convicted Mexican drug lord known as "El Chapo", has escaped twice from maximum-security prisons in Mexico, once by digging a mile-long tunnel from his cell.
But on Wednesday, US authorities made sure that a third escape for Guzman never happens.
A federal judge in Brooklyn, while giving life sentence to "El Chapo", sent him to the US Penitentiary, Administrative Maximum Facility in Florence, Colorado, the cumbersome name for what is better known as ADX Florence, the nation's most secure "Supermax" prison.
No one has escaped from the prison since it opened in 1994, and Guzman would join a long list of the most infamous of criminals who call it home.
"It's very well designed for its purpose, to hold the most dangerous offenders in the federal prison system," said Martin Horn, a professor at the John Jay College of Criminal Justice and former commissioner of the New York City Department of Correction.
"In his previous two escapes, Guzman has demonstrated that he may be a greater risk of escaping than pretty much anyone else. That makes ADX Florence an appropriate place for him," Horn added.
Located about 115 miles (185 km) south of Denver, ADX Florence is nicknamed "Alcatraz of the Rockies" after the San Francisco prison whose inmates included the gangsters Al Capone and George "Machine Gun" Kelly, and Robert Franklin Stroud, known as the Birdman of Alcatraz.
ADX Florence's current roster of about 376 inmates reads like a who's who of notorious criminals.
Among those calling the prison home are "Unabomber" Ted Kaczynski, 9/11 conspirator Zacarias Moussaoui, Terry Nichols from the 1995 Oklahoma City bombing, "Shoe Bomber" Richard Reid, Boston Marathon bomber Dzhokhar Tsarnaev, and Ramzi Yousef from the 1993 World Trade Center bombing in New York.
Prisoners are typically confined for around 23 hours a day to solitary cells, each with a narrow window about 42 inches (107 cm) high and angled upward so only the sky is visible.
They can watch TV in their cells, and have access to religious services, educational programs and a commissary.
But special restrictions are used to ensure that inmates cannot exert influence or make threats beyond the prison walls.
Prisoners cannot move around without being escorted. Head counts are done at least six times a day.
Guzman's first escape came in 2001, purportedly in a laundry cart and with the help of prison officials he had corrupted. His second escape, through the tunnel, came 14 years later.
Horn said ADX Florence "is literally built into the side of a mountain, with a robust security infrastructure."
Could Guzman penetrate that? "I would never say never," he said, "but it's highly unlikely."