One of the most reliable medications for easing pain is paracetamol. These tablets provide hassle-free, immediate relief that has been shown to be effective for decades. However, professionals have cautioned those who frequently take paracetamol about grave health risks.

A team at the University of Edinburgh conducted a recent study in which they evaluated the effects of the medicine on mice and came to the conclusion that it damages living things. The result, according to the scientists, may guide future studies into treatments intended to offset the negative effects of the medicine.

Also read:&nbsp;<a data-ctorig="https://www.wionews.com/science/does-paracetamols-use-pose-any-risk-study-makes-the-striking-revelation-451403" data-cturl="https://www.google.com/url?client=internal-element-cse&amp;cx=006054055338965708568:09spwrlibei&amp;q=https://www.wionews.com/science/does-paracetamols-use-pose-any-risk-study-makes-the-striking-revelation-451403&amp;sa=U&amp;ved=2ahUKEwiXkOvfj7qEAxVKl1YBHQvJB8oQFnoECAAQAg&amp;usg=AOvVaw1T7228BOFkArAIBaAAKnR9" dir="ltr" href="https://www.wionews.com/science/does-paracetamols-use-pose-any-risk-study-makes-the-striking-revelation-451403" target="_blank">Does&nbsp;paracetamol's&nbsp;use pose any risk?</a>

Researchers cautioned that patients who use an excessive amount of the medication may have severe side effects. For individuals with persistent pain, a typical dosage of paracetamol is four grams per day.

"Scientists at the University of Edinburgh studied the impact of paracetamol on liver cells in human and mouse tissue, and tests showed that in certain settings paracetamol can damage the liver by harming vital structural connections between adjacent cells in the organ," the study said.

According to the research, ‘paracetamol’ can damage the liver in specific situations by damaging key structural connections between adjacent cells in the organ, which was investigated by researchers at the University of Edinburgh on the effects of the drug on liver cells in human and mouse tissue.

When the liver's tissue structure is harmed, cells become dysfunctional and may even die, according to the statement that follows. "These cell wall connections, known as tight junctions," are what cause the damage.

This work represents the first to connect liver damage, like to that observed in diseases like cancer, cirrhosis, and hepatitis, with paracetamol toxicity.

The study was published in the journal Scientific Reports and involved researchers from the Scottish National Blood Transfusion Service, the <a href="https://www.ed.ac.uk/research-innovation/animal-research/news/paracetamol-study-sheds-light-on-liver-damage">Universities of Edinburgh</a> and Oslo.

(With inputs from agencies)

One of the most reliable medications for easing pain is paracetamol. These tablets provide hassle-free, immediate relief that has been shown to be effective for decades.

One of the most reliable medications for easing pain is paracetamol. These tablets provide hassle-free, immediate relief that has been shown to be effective for decades. However, professionals have cautioned those who frequently take paracetamol about grave health risks. A team at the University of Edinburgh conducted a recent study in which they evaluated the effects of the medicine on mice and came to the conclusion that it damages living things. The result, according to the scientists, may guide future studies into treatments intended to offset the negative effects of the medicine. Also read: Does paracetamol's use pose any risk? Researchers cautioned that patients who use an excessive amount of the medication may have severe side effects. For individuals with persistent pain, a typical dosage of paracetamol is four grams per day. "Scientists at the University of Edinburgh studied the impact of paracetamol on liver cells in human and mouse tissue, and tests showed that in certain settings paracetamol can damage the liver by harming vital structural connections between adjacent cells in the organ," the study said. According to the research, ‘paracetamol’ can damage the liver in specific situations by damaging key structural connections between adjacent cells in the organ, which was investigated by researchers at the University of Edinburgh on the effects of the drug on liver cells in human and mouse tissue. When the liver's tissue structure is harmed, cells become dysfunctional and may even die, according to the statement that follows. "These cell wall connections, known as tight junctions," are what cause the damage. This work represents the first to connect liver damage, like to that observed in diseases like cancer, cirrhosis, and hepatitis, with paracetamol toxicity. The study was published in the journal Scientific Reports and involved researchers from the Scottish National Blood Transfusion Service, the Universities of Edinburgh and Oslo. (With inputs from agencies)

Study shows how paracetamol, a common painkiller, may affect the liver

The Indian Pharmacopoeia Commission (IPC) has issued a drug safety alert regarding the Meftal painkiller, saying the pill has&nbsp;adverse reactions associated with its constituent, mefenamic acid. The alert specifically mentions the risk of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome.

Meftal, containing mefenamic acid, is commonly prescribed for various conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhoea, mild to moderate pain, inflammation, fever, and dental pain.

DRESS syndrome is a severe allergic reaction linked to certain medications, with symptoms such as skin rash, fever, and lymphadenopathy appearing between two and eight weeks after drug intake.

"Healthcare professionals, patients/consumers are advised to closely monitor the possibility of the above adverse drug reaction (ADR) associated with the use of the suspected drug," according to the alert, issued on November 30.

<a href="https://www.wionews.com/world/japan-approves-medical-cannabis-use-toughens-recreational-marijuana-ban-in-landmark-drug-law-revision-667218">Also read |&nbsp;Japan approves medical cannabis use, toughens recreational marijuana ban in landmark drug law revision</a>

<h2>What's the cautionary advice?</h2>

Healthcare professionals and patients are strongly advised to closely monitor the possibility of the mentioned adverse drug reaction associated with Meftal usage.

Also watch |&nbsp;Gravitas Plus: Unlocking the power of Traditional Medicine

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"If such a reaction is encountered, people should report the matter to the national coordination centre of the PvPI under the commission by filing a form on the website - www.ipc.gov.in - or through android mobile app ADR PvPI and PvPI helpline number 1800-180-3024," the release stated.

<a href="https://www.wionews.com/india-news/india-bans-14-fixed-dose-combination-drugs-including-nimesulide-and-paracetamol-report-600393">Also read |&nbsp;India bans 14 fixed-dose combination drugs including nimesulide and paracetamol: Report</a>

The IPC urges vigilance for symptoms indicative of DRESS syndrome. In case such reactions are observed, individuals are encouraged to promptly report the matter to the national coordination centre of the PvPI. Reporting can be done through the IPC's official website (<a href="http://www.ipc.gov.in/" target="_new">www.ipc.gov.in</a>), the android mobile app ADR PvPI, or the PvPI helpline number 1800-180-3024.

(With inputs from agencies)

&nbsp;

The Indian Pharmacopoeia Commission (IPC) has issued a drug safety alert regarding the Meftal painkiller, saying the pill has adverse reactions associated with its constituent, mefenamic acid.

The Indian Pharmacopoeia Commission (IPC) has issued a drug safety alert regarding the Meftal painkiller, saying the pill has adverse reactions associated with its constituent, mefenamic acid. The alert specifically mentions the risk of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome. Meftal, containing mefenamic acid, is commonly prescribed for various conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhoea, mild to moderate pain, inflammation, fever, and dental pain. DRESS syndrome is a severe allergic reaction linked to certain medications, with symptoms such as skin rash, fever, and lymphadenopathy appearing between two and eight weeks after drug intake. "Healthcare professionals, patients/consumers are advised to closely monitor the possibility of the above adverse drug reaction (ADR) associated with the use of the suspected drug," according to the alert, issued on November 30. Also read | Japan approves medical cannabis use, toughens recreational marijuana ban in landmark drug law revision What's the cautionary advice? Healthcare professionals and patients are strongly advised to closely monitor the possibility of the mentioned adverse drug reaction associated with Meftal usage. Also watch | Gravitas Plus: Unlocking the power of Traditional Medicine "If such a reaction is encountered, people should report the matter to the national coordination centre of the PvPI under the commission by filing a form on the website - www.ipc.gov.in - or through android mobile app ADR PvPI and PvPI helpline number 1800-180-3024," the release stated. Also read | India bans 14 fixed-dose combination drugs including nimesulide and paracetamol: Report The IPC urges vigilance for symptoms indicative of DRESS syndrome. In case such reactions are observed, individuals are encouraged to promptly report the matter to the national coordination centre of the PvPI. Reporting can be done through the IPC's official website (www.ipc.gov.in), the android mobile app ADR PvPI, or the PvPI helpline number 1800-180-3024. (With inputs from agencies)

Taking painkiller Meftal casually? Indian government says it can cause adverse reactions

Painkillers such as paracetamol, ibuprofen, and aspirin can do more harm than good for chronic pain, health officials have said.

Long term use of painkiller can be harmful | How painkillers impact the body | PCM