Tbilisi, Georgia
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Eleven Indian nationals were found dead at a restaurant in Gudauri, a mountain resort in Georgia, according to a statement by the Indian embassy in Tbilisi.
Georgia’s Ministry of Internal Affairs stated that an initial inspection revealed no signs of injuries or violence. Local media, citing police reports, said all victims died due to carbon monoxide poisoning.
In a statement, the Indian embassy expressed its grief over the incident: “The Embassy of India in Tbilisi is saddened to learn of the unfortunate passing of eleven Indian nationals in Gudauri, Georgia, and extends its deepest condolences to their families. The Embassy is working closely with local authorities to facilitate the prompt repatriation of the mortal remains to India. We are also in contact with the bereaved families and are committed to providing all possible support.”
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Initially, the embassy had reported 12 victims were Indian nationals. However, Georgia’s internal affairs ministry clarified that 11 were foreigners, while one victim was a Georgian citizen. This was later confirmed by the Indian embassy.
The police have launched an investigation under Article 116 of the Georgian Criminal Code, which concerns negligent manslaughter. Preliminary findings suggest that a power generator was placed in an enclosed space near the bedrooms. It is believed the generator was switched on, likely after a power outage on Friday night, which led to the carbon monoxide poisoning.
A forensic medical examination has been called to confirm the “exact cause of death.”
Gudauri, located in the Caucasus Mountains in the Mtskheta-Mtianeti region, is a well-known tourist destination for skiing and snowboarding enthusiasts. Positioned at an altitude of approximately 2,200 metres (7,200 feet), it is about 120 kilometres (75 miles) north of Georgia’s capital, Tbilisi.
The resort, which dates back to the 19th century, was historically a trading post along the Georgian Military Road, connecting Russia and Georgia.
(With inputs from agencies)

In a statement, the Indian embassy expressed grief over the incident, “The Embassy of India in Tbilisi is saddened to learn of the unfortunate passing of eleven Indian nationals in Gudauri, Georgia, and extends its deepest condolences to their families.”



Tbilisi, Georgia Eleven Indian nationals were found dead at a restaurant in Gudauri, a mountain resort in Georgia, according to a statement by the Indian embassy in Tbilisi. Georgia’s Ministry of Internal Affairs stated that an initial inspection revealed no signs of injuries or violence. Local media, citing police reports, said all victims died due to carbon monoxide poisoning. In a statement, the Indian embassy expressed its grief over the incident: “The Embassy of India in Tbilisi is saddened to learn of the unfortunate passing of eleven Indian nationals in Gudauri, Georgia, and extends its deepest condolences to their families. The Embassy is working closely with local authorities to facilitate the prompt repatriation of the mortal remains to India. We are also in contact with the bereaved families and are committed to providing all possible support.” Also read: 80 lakh SIM cards deactivated: India's uses AI tools to tackle cybercrime Initially, the embassy had reported 12 victims were Indian nationals. However, Georgia’s internal affairs ministry clarified that 11 were foreigners, while one victim was a Georgian citizen. This was later confirmed by the Indian embassy. The police have launched an investigation under Article 116 of the Georgian Criminal Code, which concerns negligent manslaughter. Preliminary findings suggest that a power generator was placed in an enclosed space near the bedrooms. It is believed the generator was switched on, likely after a power outage on Friday night, which led to the carbon monoxide poisoning. A forensic medical examination has been called to confirm the “exact cause of death.” Gudauri, located in the Caucasus Mountains in the Mtskheta-Mtianeti region, is a well-known tourist destination for skiing and snowboarding enthusiasts. Positioned at an altitude of approximately 2,200 metres (7,200 feet), it is about 120 kilometres (75 miles) north of Georgia’s capital, Tbilisi. The resort, which dates back to the 19th century, was historically a trading post along the Georgian Military Road, connecting Russia and Georgia. (With inputs from agencies)

11 Indians die from carbon monoxide poisoning at Georgia’s Gudauri mountain resort, probe underway

Eleven Indian nationals were found dead at a restaurant in Gudauri, a mountain resort in Georgia, according to a statement by the Indian embassy in Tbilisi. Georgia’s Ministry of Internal Affairs stated that an initial inspection revealed no signs of injuries or violence.

Eleven Indian nationals were found dead at a restaurant in Gudauri, a mountain resort in Georgia, according to a statement by the Indian embassy in Tbilisi. Georgia’s Ministry of Internal Affairs stated that an initial inspection revealed no signs of injuries or violence. Local media, citing police reports, said all victims died due to carbon monoxide poisoning. In a statement, the Indian embassy expressed its grief over the incident: “The Embassy of India in Tbilisi is saddened to learn of the unfortunate passing of eleven Indian nationals in Gudauri, Georgia, and extends its deepest condolences to their families. The Embassy is working closely with local authorities to facilitate the prompt repatriation of the mortal remains to India. We are also in contact with the bereaved families and are committed to providing all possible support.” Also read: 80 lakh SIM cards deactivated: India's uses AI tools to tackle cybercrime Initially, the embassy had reported 12 victims were Indian nationals. However, Georgia’s internal affairs ministry clarified that 11 were foreigners, while one victim was a Georgian citizen. This was later confirmed by the Indian embassy. The police have launched an investigation under Article 116 of the Georgian Criminal Code, which concerns negligent manslaughter. Preliminary findings suggest that a power generator was placed in an enclosed space near the bedrooms. It is believed the generator was switched on, likely after a power outage on Friday night, which led to the carbon monoxide poisoning. A forensic medical examination has been called to confirm the “exact cause of death.” Gudauri, located in the Caucasus Mountains in the Mtskheta-Mtianeti region, is a well-known tourist destination for skiing and snowboarding enthusiasts. Positioned at an altitude of approximately 2,200 metres (7,200 feet), it is about 120 kilometres (75 miles) north of Georgia’s capital, Tbilisi. The resort, which dates back to the 19th century, was historically a trading post along the Georgian Military Road, connecting Russia and Georgia. (With inputs from agencies)

Natalie Nasatka, a resident of Delaware, narrowly escaped a potentially fatal incident, all thanks to her quick thinking and the intervention of her Apple Watch's SOS feature.

On December 29, Nasatka, feeling unusually tired and battling blurry vision, instinctively used her watch to call for help. Little did she know that this swift action would prove to be life-saving, as it was later revealed she was suffering from carbon monoxide poisoning.

Nasatka woke up at 8 am, sensing unusual fatigue, and decided to cancel her appointments before drifting off on the couch.

The early warning signs, coupled with her Apple Watch's intervention, ensured a prompt response from emergency services, ultimately saving her life.

"It was extremely scary. I ended up losing consciousness. I was feeling extremely exhausted. My vision was getting blurry," shared Natalie with CBS News.&nbsp;

<a href="https://www.wionews.com/world/us-over-50-suffer-carbon-monoxide-poisoning-during-church-service-in-utah-675893">Also read |&nbsp;US: Over 50 suffer carbon monoxide poisoning during church service in Utah</a>

<h2>Dramatic rescue and medical implications</h2>

As emergency responders arrived, Nasatka recalls their urgent entry into her home. "When I heard the firefighters yell out 'fire department' and they yanked me out of bed, I just started crying and saying, 'I want to live. I want to live,'" she expressed.

Dr&nbsp;Lynn Farrugia, an emergency department physician, stressed on&nbsp;the critical nature of carbon monoxide poisoning, noting the potential irreversible damage to the heart and brain when oxygen deprivation occurs, while speaking to CBS News.

"The carbon monoxide was confirmed because the fire department monitor read 80 parts per million in the apartment, which is extremely high," added Dr Farrugia. Nasatka suspects a faulty heater as the source of the gas leak, a common cause of carbon monoxide poisoning during the winter season.

Carbon monoxide, commonly known as "CO", is an odorless and colourless gas that can be lethal. The Centers for Disease Control and Prevention (CDC) highlight that CO is present in fumes produced when burning fuel in various sources such as cars, trucks, stoves, lanterns, grills, fireplaces, gas ranges, or furnaces. The gas can accumulate indoors, posing a threat to individuals and animals who inhale it.

<a href="https://www.wionews.com/health-and-wellness/pollution-makes-respiratory-illnesses-worse-in-winter-season-what-should-be-preventive-approach-671460">Also read&nbsp;| Pollution makes respiratory illnesses worse in winter season: What should be preventive approach?</a>

The symptoms of carbon monoxide poisoning, often described as "flu-like," include headache, dizziness, weakness, upset stomach, vomiting, chest pain, and confusion. In severe cases, CO exposure can lead to unconsciousness or death, particularly for those sleeping or intoxicated, who may succumb to poisoning before exhibiting symptoms.

(With inputs from agencies)

Natalie Nasatka, a resident of Delaware, narrowly escaped a potentially fatal incident, all thanks to her quick thinking and the intervention of her Apple Watch's SOS feature.

Natalie Nasatka, a resident of Delaware, narrowly escaped a potentially fatal incident, all thanks to her quick thinking and the intervention of her Apple Watch's SOS feature. On December 29, Nasatka, feeling unusually tired and battling blurry vision, instinctively used her watch to call for help. Little did she know that this swift action would prove to be life-saving, as it was later revealed she was suffering from carbon monoxide poisoning. Nasatka woke up at 8 am, sensing unusual fatigue, and decided to cancel her appointments before drifting off on the couch. The early warning signs, coupled with her Apple Watch's intervention, ensured a prompt response from emergency services, ultimately saving her life. "It was extremely scary. I ended up losing consciousness. I was feeling extremely exhausted. My vision was getting blurry," shared Natalie with CBS News. Also read | US: Over 50 suffer carbon monoxide poisoning during church service in Utah Dramatic rescue and medical implications As emergency responders arrived, Nasatka recalls their urgent entry into her home. "When I heard the firefighters yell out 'fire department' and they yanked me out of bed, I just started crying and saying, 'I want to live. I want to live,'" she expressed. Dr Lynn Farrugia, an emergency department physician, stressed on the critical nature of carbon monoxide poisoning, noting the potential irreversible damage to the heart and brain when oxygen deprivation occurs, while speaking to CBS News. "The carbon monoxide was confirmed because the fire department monitor read 80 parts per million in the apartment, which is extremely high," added Dr Farrugia. Nasatka suspects a faulty heater as the source of the gas leak, a common cause of carbon monoxide poisoning during the winter season. Carbon monoxide, commonly known as "CO", is an odorless and colourless gas that can be lethal. The Centers for Disease Control and Prevention (CDC) highlight that CO is present in fumes produced when burning fuel in various sources such as cars, trucks, stoves, lanterns, grills, fireplaces, gas ranges, or furnaces. The gas can accumulate indoors, posing a threat to individuals and animals who inhale it. Also read | Pollution makes respiratory illnesses worse in winter season: What should be preventive approach? The symptoms of carbon monoxide poisoning, often described as "flu-like," include headache, dizziness, weakness, upset stomach, vomiting, chest pain, and confusion. In severe cases, CO exposure can lead to unconsciousness or death, particularly for those sleeping or intoxicated, who may succumb to poisoning before exhibiting symptoms. (With inputs from agencies)

Apple watch credited for saving US woman’s life during carbon monoxide leak

According to a report by AFP, at least 70 people have died due to severe cold in Afghanistan amid a wave of freezing temperatures. Since last week, mercury has plunged in Kabul and several other regions, the lowest temperature recorded was -33 degrees Celsius in the country’s central region Ghor.&nbsp;

The head of Afghanistan’s meteorology office, told AFP, “This winter is by far the coldest in recent years”. He added, “We expect the cold wave to continue for another week or more.” Meanwhile, the country’s ministry of disaster management said 70 people and 70,000 cattle have died over the past eight days or so because of the sudden drop in temperature. &nbsp;&nbsp;

What is happening in Herat?

At least 140 people including women and children were hospitalised for carbon monoxide poisoning at home in Afghanistan’s Herat province in the span of 24 hours, on Tuesday (January 17), said a report by TOLOnews agency citing officials. This comes as the residents of the province have been forced to use gas as their option to stay warm during the winter when the average temperature in the province drops below 10 degrees Celsius in the month of January.&nbsp;

ALSO READ |&nbsp;<a href="https://www.wionews.com/photos/in-pics-severe-cold-temperatures-batter-nations-553288/#worst-snowstorm-us-has-ever-seen-553287">In Pics | Severe cold temperatures batter nations</a>

“Within the past 24 hours, 130 to 140 patients have been brought to the emergency ward of the hospital,” said Ahmad Farhad Afzali, head of the hospital, as per the media report. Health officials have also attributed the rise in the number of patients to the sudden drop&nbsp;in temperature. Additionally, the report also says that some residents have been using coal to warm their houses which also causes carbon monoxide poisoning.&nbsp;

Doctors have also warned how the negligence of families about the use of gas can be deadly and causes such unfortunate incidents. “We don’t have power, and we are forced to use the gas. So far, two of my family members have died of carbon monoxide poisoning,” said Shakila, a resident of Herat province to TOLOnews.&nbsp;

ALSO READ |&nbsp;<a href="https://www.wionews.com/south-asia/afghan-hospital-wards-fill-with-children-suffering-from-pneumonia-549997">Afghan hospital wards full with children suffering from pneumonia</a>

Since the United States’ withdrawal and the Taliban’s takeover in 2021, this is the second winter that Afghanistan has faced as it continues to witness one of the worst humanitarian and economic crises with poverty, malnutrition, and more than half of the country's 38 million people facing hunger.&nbsp;

(With inputs from agencies)&nbsp; 
 
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According to a report by AFP, at least 70 people have died due to severe cold in Afghanistan amid a wave of freezing temperatures. Since last week, mercury has plunged in Kabul and several other regions, the lowest temperature recorded was -33 degrees Celsius in the country’s central region Ghor.

According to a report by AFP, at least 70 people have died due to severe cold in Afghanistan amid a wave of freezing temperatures. Since last week, mercury has plunged in Kabul and several other regions, the lowest temperature recorded was -33 degrees Celsius in the country’s central region Ghor. The head of Afghanistan’s meteorology office, told AFP, “This winter is by far the coldest in recent years”. He added, “We expect the cold wave to continue for another week or more.” Meanwhile, the country’s ministry of disaster management said 70 people and 70,000 cattle have died over the past eight days or so because of the sudden drop in temperature. What is happening in Herat? At least 140 people including women and children were hospitalised for carbon monoxide poisoning at home in Afghanistan’s Herat province in the span of 24 hours, on Tuesday (January 17), said a report by TOLOnews agency citing officials. This comes as the residents of the province have been forced to use gas as their option to stay warm during the winter when the average temperature in the province drops below 10 degrees Celsius in the month of January. ALSO READ | In Pics | Severe cold temperatures batter nations “Within the past 24 hours, 130 to 140 patients have been brought to the emergency ward of the hospital,” said Ahmad Farhad Afzali, head of the hospital, as per the media report. Health officials have also attributed the rise in the number of patients to the sudden drop in temperature. Additionally, the report also says that some residents have been using coal to warm their houses which also causes carbon monoxide poisoning. Doctors have also warned how the negligence of families about the use of gas can be deadly and causes such unfortunate incidents. “We don’t have power, and we are forced to use the gas. So far, two of my family members have died of carbon monoxide poisoning,” said Shakila, a resident of Herat province to TOLOnews. ALSO READ | Afghan hospital wards full with children suffering from pneumonia Since the United States’ withdrawal and the Taliban’s takeover in 2021, this is the second winter that Afghanistan has faced as it continues to witness one of the worst humanitarian and economic crises with poverty, malnutrition, and more than half of the country's 38 million people facing hunger. (With inputs from agencies) WATCH WION LIVE HERE You can now write for wionews.com and be a part of the community. Share your stories and opinions with us here.

Afghanistan: 70 die from cold in freezing winter, 140 hospitalised for carbon monoxide poisoning

Three friends from America, two men and a woman, were found dead in their Airbnb apartment in a city in Mexico. The authorities confirmed that they died due to carbon monoxide poisoning.

According to reports, Kandace Florence, Jordan Marshall and Courtez Hall were staying at a rental in a residential complex in La Rosita when they were found dead on October 30.&nbsp;All of them were in town for the Day of the Dead festivities.

The officials found an intense gas smell in the apartment, following which they concluded that the three were poisoned by gas inhalation.

A spokesperson for the attorney general's office told ABC News that the smell was coming from a defunct gas boiler in the apartment, which released carbon monoxide—a colourless and odourless gas.

The spokesperson said that one of the victims was found in the shower, which led the authorities to believe that it could have activated the boiler.

Commenting on the tragedy, an Airbnb spokesperson told the news outlet, “This is a terrible tragedy and our thoughts are with the families and loved ones as they face this heavy loss."

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"Our priority now is to provide support to those affected while the authorities investigate what happened and we are available to cooperate with the investigation in any way we can."

The US Embassy in Mexico said that it is in contact with the families of the deceased.

Also read |&nbsp;<a href="https://www.wionews.com/world/shooting-in-mexico-bar-leaves-9-dead-533108" hreflang="en">Shooting in Mexico bar leaves 9 dead</a>

"We stand ready to provide all appropriate consular assistance," it said in a statement earlier this week.

"Out of respect for the privacy of the families, we have nothing further to add at this time."

The latest death comes a month after another American died from carbon monoxide poisoning while staying in a vacation rental in Mexico City.

(With inputs from agencies)

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Three friends from America, two men and a woman, were found dead in their Airbnb apartment in a city in Mexico. The authorities confirmed that they died due to carbon monoxide poisoning.

Three friends from America, two men and a woman, were found dead in their Airbnb apartment in a city in Mexico. The authorities confirmed that they died due to carbon monoxide poisoning. According to reports, Kandace Florence, Jordan Marshall and Courtez Hall were staying at a rental in a residential complex in La Rosita when they were found dead on October 30. All of them were in town for the Day of the Dead festivities. The officials found an intense gas smell in the apartment, following which they concluded that the three were poisoned by gas inhalation. A spokesperson for the attorney general's office told ABC News that the smell was coming from a defunct gas boiler in the apartment, which released carbon monoxide—a colourless and odourless gas. The spokesperson said that one of the victims was found in the shower, which led the authorities to believe that it could have activated the boiler. Commenting on the tragedy, an Airbnb spokesperson told the news outlet, “This is a terrible tragedy and our thoughts are with the families and loved ones as they face this heavy loss." Also read | Trump slams reports he was 'livid' at Melania for making him back Mehmet Oz "Our priority now is to provide support to those affected while the authorities investigate what happened and we are available to cooperate with the investigation in any way we can." The US Embassy in Mexico said that it is in contact with the families of the deceased. Also read | Shooting in Mexico bar leaves 9 dead "We stand ready to provide all appropriate consular assistance," it said in a statement earlier this week. "Out of respect for the privacy of the families, we have nothing further to add at this time." The latest death comes a month after another American died from carbon monoxide poisoning while staying in a vacation rental in Mexico City. (With inputs from agencies) WATCH WION LIVE HERE:

Three Americans die due to carbon monoxide poisoning in Mexico  

The US National Centre for Atmospheric Research (NCAR) has found that carbon monoxide levels have spiked due to billowing smoke from wildfires in the last few years.

The wildfires in the US Pacific north-west have&nbsp;been fueled by climate change that is making the atmosphere drier and warmer.

According to project scientist Dr Rebecca Buchholz, “Our research contributes to the growing body of research that shows that fires,&nbsp;in particular Pacific north-west region fires – are becoming more important for North American air quality.”

“There is definitely a feedback between fires and climate. It is telling us that fires are compromising the ability of the atmosphere to self-clean,” she added.

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During her analysis of carbon monoxide's impact on the atmospheric chemistry, between 2002 to 2018, she found how other sources of pollution may be connected to the flames.

When action is taken on the classical pollutants, particulate matter, ozone, nitrogen dioxide, sulfur dioxide, and carbon monoxide, it also has an impact on other damaging pollutants.&nbsp;

Buchholz said that in the case of carbon monoxide, levels are dangerous at 10-20 parts per million (ppm), and symptoms become apparent above 70 ppm.

<a href="https://www.wionews.com/photos/how-climate-change-will-impact-the-worlds-regions-differently-457772">Also see |&nbsp;How climate change will impact the world's regions differently</a>

Air contaminants are offsetting the recent reductions in emissions as per NCAR that is a US-funded research and development centre.&nbsp;

While it is managed by the non-profit University Corporation for Atmospheric Research and it is funded by the National Science Foundation.

Scientists believe that exposure to carbon monoxide gas decreases the heart’s ability to contract in a way that is distinct from the effects of oxygen deprivation.

Patients with a history of moderate-to-severe carbon monoxide toxicity have higher rates of illness and death from heart disease years after carbon monoxide exposure.

(With inputs from agencies)

The US National Centre for Atmospheric Research (NCAR) has found that carbon monoxide levels have spiked due to billowing smoke from wildfires in the last few years.

The US National Centre for Atmospheric Research (NCAR) has found that carbon monoxide levels have spiked due to billowing smoke from wildfires in the last few years. The wildfires in the US Pacific north-west have been fueled by climate change that is making the atmosphere drier and warmer. According to project scientist Dr Rebecca Buchholz, “Our research contributes to the growing body of research that shows that fires, in particular Pacific north-west region fires – are becoming more important for North American air quality.” “There is definitely a feedback between fires and climate. It is telling us that fires are compromising the ability of the atmosphere to self-clean,” she added. During her analysis of carbon monoxide's impact on the atmospheric chemistry, between 2002 to 2018, she found how other sources of pollution may be connected to the flames. When action is taken on the classical pollutants, particulate matter, ozone, nitrogen dioxide, sulfur dioxide, and carbon monoxide, it also has an impact on other damaging pollutants. Buchholz said that in the case of carbon monoxide, levels are dangerous at 10-20 parts per million (ppm), and symptoms become apparent above 70 ppm. Also see | How climate change will impact the world's regions differently Air contaminants are offsetting the recent reductions in emissions as per NCAR that is a US-funded research and development centre. While it is managed by the non-profit University Corporation for Atmospheric Research and it is funded by the National Science Foundation. Scientists believe that exposure to carbon monoxide gas decreases the heart’s ability to contract in a way that is distinct from the effects of oxygen deprivation. Patients with a history of moderate-to-severe carbon monoxide toxicity have higher rates of illness and death from heart disease years after carbon monoxide exposure. (With inputs from agencies)

Carbon monoxide levels spike due to billowing smoke from wildfires fueled by climate change: Study

23 workers of a metalwork company in China suffered carbon monoxide poisoning after a power cut knocked off the factory's exhaust. Palki Sharma tells you how China is struggling to find solutions for its power crisis.

Gravitas: China: 23 workers suffer carbon monoxide poisoning after a power cut

In a new study, researchers have developed an oral prodrug that delivers carbon monoxide to protect against acute kidney injury.&nbsp;Researchers from Georgia State University, led by Binghe Wang, published the study in Chemical Science.

Scientists have discovered that carbon monoxide (CO) can have beneficial effects by reducing inflammation and protecting cells against injury, even though it is toxic in large doses. CO has been found to protect kidneys, lungs, gastrointestinal tract, and liver, as well as other organs, from injury.

Also read |&nbsp;<a href="https://www.wionews.com/world/study-suggests-possible-link-between-alcohol-consumption-and-cancer-398739">Study suggests possible link between alcohol consumption and cancer</a>

Over a period of five years, using saccharine (found in Sweet'N Low) and acesulfame (found in Splenda) as "carrier" molecules, Wang's team developed prodrugs for treating CO that could be administered orally.

Prodrugs are inactive compounds that, when administered undergo a chemical process in the body, release&nbsp;active pharmacological agents. When exposed to water, these molecules decompose, releasing carbon dioxide.&nbsp;

These are the first examples of orally active, organic CO prodrugs that use a benign carrier and have a demonstrated safety profile.

Also read |&nbsp;<a href="https://www.wionews.com/science/drinking-coffee-reduces-risk-of-contracting-coronavirus-study-397490">Drinking coffee reduces risk of contracting coronavirus: Study</a>

Wang, a senior author of the paper and a scholar at the Georgia Research Alliance, says that it is difficult to deliver gas therapeutics, much less poisonous gases, to patients and that this work represents an important step toward developing alternative delivery forms.&nbsp;

In order to be sure that the carrier will be safe to be used in a pill for human consumption, they wanted to work with a carrier that has a very well-characterised safety profile, she added.

A prodrug, CO-306, was tested for its potential to protect against acute kidney damage. By administering the prodrug along with the carrier molecule, saccharine to mice, the researchers found that it reduced the biomarkers of renal damage, suggesting that CO-306 could be developed into a viable therapeutic molecule.

Mouse models were used to replicate kidney tissue damage associated with muscle damage, sickle cell disease, malaria, cardiopulmonary bypass surgery, and severe sepsis.

Also read |&nbsp;<a href="https://www.wionews.com/science/study-claiming-smokers-less-vulnerable-to-covid-19-retracted-as-authors-linked-to-tobacco-industry-379255">Study claiming smokers less vulnerable to COVID-19 retracted as authors linked to tobacco industry</a>

A more extensive animal model study and safety assessment will be conducted on CO-306 by Professor Wang and colleagues at Georgia State University, Vanderbilt University, Harvard Medical School, and the University of Mississippi before human clinical trials may begin.&nbsp;

In addition, they also plan to test its effectiveness against other types of organ injuries.

Wang says CO-based therapies particularly hold promise as a method of reducing the likelihood of organ damage during transplantation and improving outcomes for transplant patients.

CO-based therapy holds particular promise as a way to reduce the risk of organ damage during transplantation and improve recovery rates for transplant patients, according to Wang.

"Science shows that exposing organs to CO gas can help preserve organs and prevent them from deteriorating during the process of transplantation," he said. "Now we need to demonstrate that these prodrugs can have a similar effect."

(With inputs from agencies)

In a new study, researchers have developed an oral prodrug that delivers carbon monoxide to protect against acute kidney injury. Researchers from Georgia State University, led by Binghe Wang, published the study in Chemical Science.

In a new study, researchers have developed an oral prodrug that delivers carbon monoxide to protect against acute kidney injury. Researchers from Georgia State University, led by Binghe Wang, published the study in Chemical Science. Scientists have discovered that carbon monoxide (CO) can have beneficial effects by reducing inflammation and protecting cells against injury, even though it is toxic in large doses. CO has been found to protect kidneys, lungs, gastrointestinal tract, and liver, as well as other organs, from injury. Also read | Study suggests possible link between alcohol consumption and cancer Over a period of five years, using saccharine (found in Sweet'N Low) and acesulfame (found in Splenda) as "carrier" molecules, Wang's team developed prodrugs for treating CO that could be administered orally. Prodrugs are inactive compounds that, when administered undergo a chemical process in the body, release active pharmacological agents. When exposed to water, these molecules decompose, releasing carbon dioxide. These are the first examples of orally active, organic CO prodrugs that use a benign carrier and have a demonstrated safety profile. Also read | Drinking coffee reduces risk of contracting coronavirus: Study Wang, a senior author of the paper and a scholar at the Georgia Research Alliance, says that it is difficult to deliver gas therapeutics, much less poisonous gases, to patients and that this work represents an important step toward developing alternative delivery forms. In order to be sure that the carrier will be safe to be used in a pill for human consumption, they wanted to work with a carrier that has a very well-characterised safety profile, she added. A prodrug, CO-306, was tested for its potential to protect against acute kidney damage. By administering the prodrug along with the carrier molecule, saccharine to mice, the researchers found that it reduced the biomarkers of renal damage, suggesting that CO-306 could be developed into a viable therapeutic molecule. Mouse models were used to replicate kidney tissue damage associated with muscle damage, sickle cell disease, malaria, cardiopulmonary bypass surgery, and severe sepsis. Also read | Study claiming smokers less vulnerable to COVID-19 retracted as authors linked to tobacco industry A more extensive animal model study and safety assessment will be conducted on CO-306 by Professor Wang and colleagues at Georgia State University, Vanderbilt University, Harvard Medical School, and the University of Mississippi before human clinical trials may begin. In addition, they also plan to test its effectiveness against other types of organ injuries. Wang says CO-based therapies particularly hold promise as a method of reducing the likelihood of organ damage during transplantation and improving outcomes for transplant patients. CO-based therapy holds particular promise as a way to reduce the risk of organ damage during transplantation and improve recovery rates for transplant patients, according to Wang. "Science shows that exposing organs to CO gas can help preserve organs and prevent them from deteriorating during the process of transplantation," he said. "Now we need to demonstrate that these prodrugs can have a similar effect." (With inputs from agencies)

Carbon monoxide can be used to protect organs during transplant: Study

23 people have been confirmed dead after a carbon monoxide leak at a coal mine in southwest China. 1 person has been rescued successfully so far.

China coal mine accident: 23 dead, 1 rescued in underground gas leak

Sixteen workers died and one is in a critical condition after being trapped underground in a coal mine in southwest China on Sunday, reported state broadcaster CCTV.

A conveyor belt caught fire in the early hours of the morning, state news agency Xinhua cited the government as saying, which produced dangerous levels of carbon monoxide.

Medics are fighting to save the life of the remaining survivor, CCTV reported.

The cause of the accident is still under investigation, said the Qijiang district government on social media platform Weibo.

The facility, Songzao Coal Mine, is owned by state energy firm Chongqing Energy and located just outside the city of Chongqing.

<a href="https://www.wionews.com/world/anti-coal-environmentalists-stage-protests-around-western-mine-in-germany-330601">Also read: Anti-coal environmentalists stage protests around western mine in Germany</a>&nbsp;

Mining accidents are common in China, where the industry has a poor safety record and regulations are often weakly enforced.

At least 14 miners were killed in a coal and gas blast last December at a mine in southwestern Guizhou province.

In December 2018, seven miners were killed in Chongqing after the connecting segment of a skip broke and fell down a shaft.

In October the same year, 21 miners died in eastern Shandong province after pressure inside a mine caused rocks to fracture and break, blocking the tunnel and trapping the workers. Only one miner was rescued alive.

Sixteen workers died and one is in a critical condition after being trapped underground in a coal mine in southwest China on Sunday, reported state broadcaster CCTV.

Sixteen workers died and one is in a critical condition after being trapped underground in a coal mine in southwest China on Sunday, reported state broadcaster CCTV. A conveyor belt caught fire in the early hours of the morning, state news agency Xinhua cited the government as saying, which produced dangerous levels of carbon monoxide. Medics are fighting to save the life of the remaining survivor, CCTV reported. The cause of the accident is still under investigation, said the Qijiang district government on social media platform Weibo. The facility, Songzao Coal Mine, is owned by state energy firm Chongqing Energy and located just outside the city of Chongqing. Also read: Anti-coal environmentalists stage protests around western mine in Germany Mining accidents are common in China, where the industry has a poor safety record and regulations are often weakly enforced. At least 14 miners were killed in a coal and gas blast last December at a mine in southwestern Guizhou province. In December 2018, seven miners were killed in Chongqing after the connecting segment of a skip broke and fell down a shaft. In October the same year, 21 miners died in eastern Shandong province after pressure inside a mine caused rocks to fracture and break, blocking the tunnel and trapping the workers. Only one miner was rescued alive.

China: 16 dead from carbon monoxide poisoning in coal mine

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