The second person who received a genetically engineered pig heart in September this year has died even as the doctors took extra precautions.

A statement from the University of Maryland Medical Center in Baltimore, where the transplant was performed, revealed that the 58-year-old man died on October 30, nearly six weeks after the surgery was performed.

Maryland team said the person, Lawrence Faucette, made progress following the surgery, spent time with family, played card games and did physical therapies.&nbsp;

But in the days leading up to his death, his body started treating the pig heart as a foreign element and attacked it. Such rejection by the immune system is usual even in the cases of traditional transplants involving human organs.

<h2>Timeline of the Faucette case</h2>

Faucette faced end-stage heart failure when he arrived at the University of Maryland Medical Center on September 14.&nbsp;

Despite his heart stopping and requiring resuscitation, he couldn't undergo a conventional heart transplant due to his critical condition.&nbsp;

Subsequently, the US Food and Drug Administration granted emergency approval for a genetically modified pig heart transplant to extend his life.&nbsp;

Watch:&nbsp;Gravitas: Pig's heart transplanted into a human

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Faucette, well-informed of the risks, agreed to have the surgery conducted.

During the initial month of his recovery, the pig heart performed well with no signs of rejection. Faucette also made progress in regaining his ability to walk.

However, he could only survive for just six weeks.

<h2>About the first case of pig heart transplant</h2>

The first recipient of a genetically engineered pig heart, David Bennett, survived for two months following the groundbreaking procedure in January 2022; however, he eventually succumbed to sudden heart failure.&nbsp;

<a href="https://www.wionews.com/science/wild-pigs-in-germany-are-radioactive-a-new-study-explains-why-630945">Also read:&nbsp;Wild pigs in Germany are radioactive. A new study explains why Wild boars in the fores</a>

The Maryland medical team speculated that Bennett's pre-existing health issues and the presence of a pig virus in his transplanted heart might have contributed to his death. Although he lived longer than the second person to get a pig heart.

<h2>Significance of ‘xenotransplantation’</h2>

Researchers at the University of Maryland Medical Center and other institutions have been exploring xenotransplantation, the transplantation of animal organs into humans, as a solution to the organ shortage crisis.&nbsp;

In the United States, more than 103,000 people are on the national transplant waiting list, with 17 individuals passing away daily while awaiting an organ.&nbsp;

(With inputs from agencies)

The second person who received a genetically engineered pig heart in September this year has died even as the doctors took extra precautions. A statement from the University of Maryland Medical Center in Baltimore, where the transplant was performed, revealed that the 58-year-old man died on October 30, nearly six weeks after the surgery was performed.

The second person who received a genetically engineered pig heart in September this year has died even as the doctors took extra precautions. A statement from the University of Maryland Medical Center in Baltimore, where the transplant was performed, revealed that the 58-year-old man died on October 30, nearly six weeks after the surgery was performed. Maryland team said the person, Lawrence Faucette, made progress following the surgery, spent time with family, played card games and did physical therapies. But in the days leading up to his death, his body started treating the pig heart as a foreign element and attacked it. Such rejection by the immune system is usual even in the cases of traditional transplants involving human organs. Timeline of the Faucette case Faucette faced end-stage heart failure when he arrived at the University of Maryland Medical Center on September 14. Despite his heart stopping and requiring resuscitation, he couldn't undergo a conventional heart transplant due to his critical condition. Subsequently, the US Food and Drug Administration granted emergency approval for a genetically modified pig heart transplant to extend his life. Watch: Gravitas: Pig's heart transplanted into a human × Faucette, well-informed of the risks, agreed to have the surgery conducted. During the initial month of his recovery, the pig heart performed well with no signs of rejection. Faucette also made progress in regaining his ability to walk. However, he could only survive for just six weeks. About the first case of pig heart transplant The first recipient of a genetically engineered pig heart, David Bennett, survived for two months following the groundbreaking procedure in January 2022; however, he eventually succumbed to sudden heart failure. Also read: Wild pigs in Germany are radioactive. A new study explains why Wild boars in the fores The Maryland medical team speculated that Bennett's pre-existing health issues and the presence of a pig virus in his transplanted heart might have contributed to his death. Although he lived longer than the second person to get a pig heart. Significance of ‘xenotransplantation’ Researchers at the University of Maryland Medical Center and other institutions have been exploring xenotransplantation, the transplantation of animal organs into humans, as a solution to the organ shortage crisis. In the United States, more than 103,000 people are on the national transplant waiting list, with 17 individuals passing away daily while awaiting an organ. (With inputs from agencies)

‘His own body attacked it': Second person to get pig heart transplant dies

Two genetically modified pig hearts were successfully transplanted into humans recently, in what is the second major move forward for pig-human heart xenotransplantation this year.

Two more pig hearts successfully transplanted into humans- effort to make up for human organs shortage

The first person to receive gene-edited heart of a pig has died two months after getting a historic transplant.

The procedure raised hopes that advances in cross-species organ donation could one day solve the chronic shortage of human organs available for donation, and the team behind the operation say they still remain optimistic about its future success.

David Bennett, 57, had received his transplant on January 7 and passed away March 8, the University of Maryland Medical System said in a statement.

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His condition began deteriorating several days ago, the hospital said in a statement on Wednesday, adding that Bennett was given "compassionate palliative care" after it became clear that he would not recover.

Bennett was able to communicate with his family during his final hours, the hospital said.

"He proved to be a brave and noble patient who fought all the way to the end. We extend our sincerest condolences to his family," said Bartley Griffith, the surgeon who led the procedure.

Bennett’s doctors said he had heart failure and an irregular heartbeat, plus a history of not complying with medical instructions.&nbsp;

<a href="https://www.wionews.com/world/patient-in-ground-breaking-heart-transplant-has-a-violent-criminal-record-444681">Also read |&nbsp;Patient in ground-breaking heart transplant has a violent criminal record</a>

Bennett’s son praised the hospital for offering the last-ditch experiment, saying the family hoped it would help further efforts to end the organ shortage.

“We are grateful for every innovative moment, every crazy dream, every sleepless night that went into this historic effort,” David Bennett Jr. said in a statement released by the University of Maryland School of Medicine. “We hope this story can be the beginning of hope and not the end.”

Bennett first came to UMMC as a patient in October and was placed on a heart-lung bypass machine to keep him alive, but he was deemed ineligible for a conventional heart transplant.

After Bennett was implanted with a pig heart that had been genetically modified to prevent rejection in a first-of-its-kind surgery, his son called the procedure "a miracle."

<a href="https://www.wionews.com/trending/in-a-first-two-kidneys-from-genetically-modified-pig-transplanted-into-brain-dead-man-446320">Also read |&nbsp;In a first, two kidneys from genetically modified pig transplanted into brain dead man</a>

The surgery, performed by a team at the hospital, was among the first to demonstrate the feasibility of a pig-to-human heart transplant, a field made possible by new gene editing tools. For Bennett, the procedure was his last option.

"Before consenting to receive the transplant, Mr. Bennett was fully informed of the procedure's risks, and that the procedure was experimental with unknown risks and benefits," the hospital said.

"We have gained invaluable insights learning that the genetically modified pig heart can function well within the human body while the immune system is adequately suppressed," said Muhammad Mohiuddin, director of the university's cardiac xenotransplantation program.

"We remain optimistic and plan on continuing our work in future clinical trials."

Reporting in US media also revealed Bennett was convicted of stabbing a man several times in 1988, leaving the victim paralysed and needing to use a wheelchair before he died in 2005.

Medical ethicists hold that a person's past criminal history should have no bearing on their future health treatment.

Pigs have long been a tantalising source of potential transplants because their organs are so similar to humans.

Prior efforts at pig-to-human transplants had failed because of genetic differences that caused organ rejection or viruses that posed an infection risk.

(With inputs from agencies)

The first person to receive gene-edited heart of a pig has died two months after getting a historic transplant. The procedure raised hopes that advances in cross-species organ donation could one day solve the chronic shortage of human organs available for donation, and the team behind the operation say they still remain optimistic about its future success.

The first person to receive gene-edited heart of a pig has died two months after getting a historic transplant. The procedure raised hopes that advances in cross-species organ donation could one day solve the chronic shortage of human organs available for donation, and the team behind the operation say they still remain optimistic about its future success. David Bennett, 57, had received his transplant on January 7 and passed away March 8, the University of Maryland Medical System said in a statement. His condition began deteriorating several days ago, the hospital said in a statement on Wednesday, adding that Bennett was given "compassionate palliative care" after it became clear that he would not recover. Bennett was able to communicate with his family during his final hours, the hospital said. "He proved to be a brave and noble patient who fought all the way to the end. We extend our sincerest condolences to his family," said Bartley Griffith, the surgeon who led the procedure. Bennett’s doctors said he had heart failure and an irregular heartbeat, plus a history of not complying with medical instructions. Also read | Patient in ground-breaking heart transplant has a violent criminal record Bennett’s son praised the hospital for offering the last-ditch experiment, saying the family hoped it would help further efforts to end the organ shortage. “We are grateful for every innovative moment, every crazy dream, every sleepless night that went into this historic effort,” David Bennett Jr. said in a statement released by the University of Maryland School of Medicine. “We hope this story can be the beginning of hope and not the end.” Bennett first came to UMMC as a patient in October and was placed on a heart-lung bypass machine to keep him alive, but he was deemed ineligible for a conventional heart transplant. After Bennett was implanted with a pig heart that had been genetically modified to prevent rejection in a first-of-its-kind surgery, his son called the procedure "a miracle." Also read | In a first, two kidneys from genetically modified pig transplanted into brain dead man The surgery, performed by a team at the hospital, was among the first to demonstrate the feasibility of a pig-to-human heart transplant, a field made possible by new gene editing tools. For Bennett, the procedure was his last option. "Before consenting to receive the transplant, Mr. Bennett was fully informed of the procedure's risks, and that the procedure was experimental with unknown risks and benefits," the hospital said. "We have gained invaluable insights learning that the genetically modified pig heart can function well within the human body while the immune system is adequately suppressed," said Muhammad Mohiuddin, director of the university's cardiac xenotransplantation program. "We remain optimistic and plan on continuing our work in future clinical trials." Reporting in US media also revealed Bennett was convicted of stabbing a man several times in 1988, leaving the victim paralysed and needing to use a wheelchair before he died in 2005. Medical ethicists hold that a person's past criminal history should have no bearing on their future health treatment. Pigs have long been a tantalising source of potential transplants because their organs are so similar to humans. Prior efforts at pig-to-human transplants had failed because of genetic differences that caused organ rejection or viruses that posed an infection risk. (With inputs from agencies)

Two months after historic transplant, first person to receive gene-edited pig heart dies

Doctors in Alabama successfully transplanted a pair of kidneys from a genetically modified pig into a brain dead man.&nbsp;

The operation was conducted at the University of Alabama in the United States. The man named Jim Parsons, 57, was declared brain dead after he suffered a bike accident in September last year.

Parsons family gave the go-ahead to the doctors to conduct the operation as the patient's kidneys were removed and two kidneys from a genetically modified pig were embedded into his body.&nbsp;

<a href="https://www.wionews.com/world/in-a-first-man-gets-genetically-modified-pig-heart-in-transplant-443747">Also Read:&nbsp;&nbsp;In a first, man gets genetically modified pig heart in transplant</a>

Reports said the transplanted kidneys began to function immediately after the operation was conducted.

Earlier this month surgeons had successfully transplanted a &nbsp;genetically modified pig's heart into a man. David Bennett became the first man to undergo the unique heart transplant.

Watch: Pig's heart transplanted into a human

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Bennett's son called the operation a "miracle" &nbsp;as a team of surgeons at the University of Maryland conducted the operation on January 7.

The operation demonstrated the success of pig-to-human heart transplants as doctors cheered amid a shortage of donor organs.

According to reports, there are 100,000 US citizens waiting for organ donations currently.

(With inputs from Agencies)&nbsp;

Doctors in Alabama successfully transplanted a pair of kidneys from a genetically modified pig into a brain dead man. The operation was conducted at the University of Alabama in the United States.

Doctors in Alabama successfully transplanted a pair of kidneys from a genetically modified pig into a brain dead man. The operation was conducted at the University of Alabama in the United States. The man named Jim Parsons, 57, was declared brain dead after he suffered a bike accident in September last year. Parsons family gave the go-ahead to the doctors to conduct the operation as the patient's kidneys were removed and two kidneys from a genetically modified pig were embedded into his body. Also Read: In a first, man gets genetically modified pig heart in transplant Reports said the transplanted kidneys began to function immediately after the operation was conducted. Earlier this month surgeons had successfully transplanted a genetically modified pig's heart into a man. David Bennett became the first man to undergo the unique heart transplant. Watch: Pig's heart transplanted into a human Bennett's son called the operation a "miracle" as a team of surgeons at the University of Maryland conducted the operation on January 7. The operation demonstrated the success of pig-to-human heart transplants as doctors cheered amid a shortage of donor organs. According to reports, there are 100,000 US citizens waiting for organ donations currently. (With inputs from Agencies)

In a first, two kidneys from genetically modified pig transplanted into brain dead man

A man in the United States has now become the first person in the world to get a heart transplant from a genetically modified pig. It was a bit of a do-or-die situation, that prompted the American medical regulator to grant permission for this experimental surgery.

United States: First pig to human heart transplant, a game-changer for organ transplants