The human eye, a marvel of biological engineering, serves as a unique portal to peek&nbsp;into the intricacies of the central nervous system. Through a pioneering approach, scientists have unearthed the potential to detect early indicators of Parkinson's disease, unveiling a new dimension in early diagnosis, up to seven years before symptoms manifest.

<h2>The power of 3D eye scans</h2>

This groundbreaking finding&nbsp;revolves around three-dimensional eye scans, routinely employed by optometrists to assess the condition of the retina, a layer of nerve cells nestled at the back of the eye, as per Science Alert.&nbsp;

What remained veiled until recently is that these scans house subtle cues pertaining to both bodily and cerebral health.

Over the past decade, researchers have embarked on an ambitious quest to harness this data for diagnosing neurological disorders such as Alzheimer's, multiple sclerosis, and schizophrenia, thus giving birth to the emerging realm of 'oculomics'.

Within this realm, Parkinson's, a perplexing nervous system disorder with an elusive etiology and cure, stands as a prominent contender.

Also read |&nbsp;<a href="https://www.wionews.com/science/this-colour-changing-fish-just-doesnt-see-with-its-eyes-study-says-theres-more-628354">This fish uses 'skin vision' to look at itself from the inside</a>

<h2>Pioneering research on retinal imaging</h2>

Pearse Keane, a professor of artificial medical intelligence at University College London and Moorfields eye hospital, said: “The eye is the only part of the body where you can directly visualise the microvascular circulation [the flow of blood through the tiniest vessels]. If you have changes in your blood or cardiovascular system, those changes may be manifested in the retinal blood vessel.” 
 
In a monumental effort, collaborators from various UK hospitals have orchestrated the largest study to date on retinal imaging for Parkinson's disease. Previously, scientists had observed anomalies in the retinas of deceased Parkinson's patients, but the applicability of these changes in a living context remained elusive. The latest findings, however, suggest otherwise, offering a potential window into the disease's onset and progression.

<h2>AI's role&nbsp;</h2>

Harnessing the capabilities of artificial intelligence, researchers scrutinised eye scans from a staggering 154,830 patients aged 40 and above.

Within this cohort, 700 individuals afflicted with Parkinson's exhibited subtle yet statistically significant variations in their retinal appearance.

A notable thinning in the inner ganglion cell layer, responsible for transmitting visual information via dopamine, stood out in specific regions.

This discovery&nbsp;served as a critical clue in the examination of eye scans from the UK Biobank database, which encompassed 67,311 individuals, including 53 diagnosed with Parkinson's during the study.

<h2>Early indicators in the eye</h2>

The research highlighted that&nbsp;the thinning of the inner ganglion cell layer can manifest in the early stages of Parkinson's, preceding the emergence of clinical symptoms.

This discovery lends support to earlier observations of ganglion thinning in individuals afflicted with Parkinson's and strengthens the premise that ocular changes can be among the earliest manifestations of the disease.

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The human eye, a marvel of biological engineering, serves as a unique portal to peek into the intricacies of the central nervous system. Through a pioneering approach, scientists have unearthed the potential to detect early indicators of Parkinson's disease, unveiling a new dimension in early diagnosis, up to seven years before symptoms manifest.

The human eye, a marvel of biological engineering, serves as a unique portal to peek into the intricacies of the central nervous system. Through a pioneering approach, scientists have unearthed the potential to detect early indicators of Parkinson's disease, unveiling a new dimension in early diagnosis, up to seven years before symptoms manifest. The power of 3D eye scans This groundbreaking finding revolves around three-dimensional eye scans, routinely employed by optometrists to assess the condition of the retina, a layer of nerve cells nestled at the back of the eye, as per Science Alert. What remained veiled until recently is that these scans house subtle cues pertaining to both bodily and cerebral health. Over the past decade, researchers have embarked on an ambitious quest to harness this data for diagnosing neurological disorders such as Alzheimer's, multiple sclerosis, and schizophrenia, thus giving birth to the emerging realm of 'oculomics'. Within this realm, Parkinson's, a perplexing nervous system disorder with an elusive etiology and cure, stands as a prominent contender. Also read | This fish uses 'skin vision' to look at itself from the inside Pioneering research on retinal imaging Pearse Keane, a professor of artificial medical intelligence at University College London and Moorfields eye hospital, said: “The eye is the only part of the body where you can directly visualise the microvascular circulation [the flow of blood through the tiniest vessels]. If you have changes in your blood or cardiovascular system, those changes may be manifested in the retinal blood vessel.” In a monumental effort, collaborators from various UK hospitals have orchestrated the largest study to date on retinal imaging for Parkinson's disease. Previously, scientists had observed anomalies in the retinas of deceased Parkinson's patients, but the applicability of these changes in a living context remained elusive. The latest findings, however, suggest otherwise, offering a potential window into the disease's onset and progression. AI's role Harnessing the capabilities of artificial intelligence, researchers scrutinised eye scans from a staggering 154,830 patients aged 40 and above. Within this cohort, 700 individuals afflicted with Parkinson's exhibited subtle yet statistically significant variations in their retinal appearance. A notable thinning in the inner ganglion cell layer, responsible for transmitting visual information via dopamine, stood out in specific regions. This discovery served as a critical clue in the examination of eye scans from the UK Biobank database, which encompassed 67,311 individuals, including 53 diagnosed with Parkinson's during the study. Early indicators in the eye The research highlighted that the thinning of the inner ganglion cell layer can manifest in the early stages of Parkinson's, preceding the emergence of clinical symptoms. This discovery lends support to earlier observations of ganglion thinning in individuals afflicted with Parkinson's and strengthens the premise that ocular changes can be among the earliest manifestations of the disease. WATCH WION LIVE HERE:

Eye scans can detect early Parkinson's signs, years ahead of symptoms: Study

According to a new world’s largest study of its kind, an artificial intelligence tool can scan eyes and accurately predict a person’s risk of “silent killer” heart diseases, in less than a minute. The research was published in the British Journal of Ophthalmology and can have significant implications like carrying out cardiovascular screening without the need for blood tests or checking the blood pressure level.&nbsp;

This breakthrough can let doctors, and healthcare workers, including ophthalmologists, examine the risk of cardiovascular disease, cardiovascular death and stroke in any patient. According to researchers, this was achieved by AI-enabled imaging of the retina in the eye to see the veins and arteries inside it. &nbsp;

“This AI tool could let someone know in 60 seconds or less their level of risk,” said the study’s lead author, professor Alicja Rudnicka to the Guardian. According to her, if someone knew their risk of cardiovascular disease, timely intervention with prescribed statins and others could not only improve cardiovascular health but also save lives.&nbsp;

The fully automated AI-enabled tool named Quartz, reportedly, accesses the potential of retinal vasculature imaging and known risk factors which enable it to predict cardiovascular health as well as potential risks, said the study. The tool was used to scan at least 88,052 images of 40 to 69-year-olds from UK Biobank participants.&nbsp; 
 
ALSO READ:&nbsp;<a href="https://www.wionews.com/science/toxic-air-particles-found-in-lungs-and-brains-of-unborn-babies-affects-development-says-study-522959">New study alarmingly finds toxic air particles in lungs and brains of unborn babies</a>

According to reports, the scientists specifically looked at aspects like the width, vessel area and degree of curvature of the arteries and veins in the retina. This data enabled them to develop prediction models for heart attack, stroke and death from circulatory disease.&nbsp;

Furthermore, this model was applied to retinal images of 7,411 participants of the European prospective investigation into cancer (Epic)-Norfolk study who were between the ages of 48 to 92, said the report. All the participants’ health was tracked for at least seven to nine years.&nbsp;

The research also showed that in men, the width, curvature and width variation of veins and arteries in the retinas were important predictors of death due to circulatory disease. On the other hand, in women, the artery area and width as well as the vein curviness and width variation were important predictors.&nbsp;

Over the years, various studies have shown that cardiovascular disease, coronary heart disease, heart failure and stroke, are some of the leading causes of health issues and death across the world. Furthermore, while there are tests that can predict the risk they are not always accurate with their estimations of who will in the future develop or die of heart disease. 
 
(With inputs from agencies) 
 
 
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According to a new world’s largest study of its kind, an artificial intelligence tool can scan eyes and accurately predict a person’s risk of “silent killer” heart diseases, in less than a minute.

According to a new world’s largest study of its kind, an artificial intelligence tool can scan eyes and accurately predict a person’s risk of “silent killer” heart diseases, in less than a minute. The research was published in the British Journal of Ophthalmology and can have significant implications like carrying out cardiovascular screening without the need for blood tests or checking the blood pressure level. This breakthrough can let doctors, and healthcare workers, including ophthalmologists, examine the risk of cardiovascular disease, cardiovascular death and stroke in any patient. According to researchers, this was achieved by AI-enabled imaging of the retina in the eye to see the veins and arteries inside it. “This AI tool could let someone know in 60 seconds or less their level of risk,” said the study’s lead author, professor Alicja Rudnicka to the Guardian. According to her, if someone knew their risk of cardiovascular disease, timely intervention with prescribed statins and others could not only improve cardiovascular health but also save lives. The fully automated AI-enabled tool named Quartz, reportedly, accesses the potential of retinal vasculature imaging and known risk factors which enable it to predict cardiovascular health as well as potential risks, said the study. The tool was used to scan at least 88,052 images of 40 to 69-year-olds from UK Biobank participants. ALSO READ: New study alarmingly finds toxic air particles in lungs and brains of unborn babies According to reports, the scientists specifically looked at aspects like the width, vessel area and degree of curvature of the arteries and veins in the retina. This data enabled them to develop prediction models for heart attack, stroke and death from circulatory disease. Furthermore, this model was applied to retinal images of 7,411 participants of the European prospective investigation into cancer (Epic)-Norfolk study who were between the ages of 48 to 92, said the report. All the participants’ health was tracked for at least seven to nine years. The research also showed that in men, the width, curvature and width variation of veins and arteries in the retinas were important predictors of death due to circulatory disease. On the other hand, in women, the artery area and width as well as the vein curviness and width variation were important predictors. Over the years, various studies have shown that cardiovascular disease, coronary heart disease, heart failure and stroke, are some of the leading causes of health issues and death across the world. Furthermore, while there are tests that can predict the risk they are not always accurate with their estimations of who will in the future develop or die of heart disease. (With inputs from agencies) WATCH WION LIVE HERE You can now write for wionews.com and be a part of the community. Share your stories and opinions with us here.

AI predicts risk of heart disease with simple eye test, in less than a minute, says study

For individuals with weak eyes, spectacles and eyeglasses are unquestionably a blessing. They allow you to walk without tripping over objects, read, and essentially just see what's in front of you. But they can also be a curse. It is very easy to forget them at home or in the car, they break easily, and Covid, masks have taught us that they fog up real easy, effectively blinding you. But what if you didn't have to wear those pesky glasses all the time? If you're living in the United States this is a possibility. The FDA (Food and Drug Administration) has recently approved an eye drop that can replace glasses.

Watch |&nbsp;WION Fineprint | US approves eye drops that could replace reading glasses

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This drug is called Vuity and it claims to improve age-related near-vision. As per an Express.co.uk report, the eye drops need to be applied once every six hours and starts working within 15 minutes of application.

According to the report, the medication is a formulated form of the well-known compound known as&nbsp;pilocarpine, and the researchers have developed&nbsp;it to&nbsp;quickly adapt to the pH of the tear film.

Also read |&nbsp;<a href="https://www.wionews.com/world/how-much-alcohol-to-drink-at-what-age-the-lancet-study-reveals-497554" hreflang="en">How much alcohol to drink at what age? The Lancet study reveals</a>

Utilising the eye's natural ability to constrict the pupil, the drop enhances near vision while preserving far vision.

The drop is most helpful for people between the ages of 40 and 55, according to the researchers' analysis of two randomised control trials involving 750 participants.

Moreover, they did not suffer any severe adverse effects; however, a few patients did report minor headaches and eye redness.

(With inputs from agencies)

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For individuals with weak eyes, spectacles and eyeglasses are unquestionably a blessing. They allow you to walk without tripping over objects, read, and essentially just see what's in front of you.

For individuals with weak eyes, spectacles and eyeglasses are unquestionably a blessing. They allow you to walk without tripping over objects, read, and essentially just see what's in front of you. But they can also be a curse. It is very easy to forget them at home or in the car, they break easily, and Covid, masks have taught us that they fog up real easy, effectively blinding you. But what if you didn't have to wear those pesky glasses all the time? If you're living in the United States this is a possibility. The FDA (Food and Drug Administration) has recently approved an eye drop that can replace glasses. Watch | WION Fineprint | US approves eye drops that could replace reading glasses This drug is called Vuity and it claims to improve age-related near-vision. As per an Express.co.uk report, the eye drops need to be applied once every six hours and starts working within 15 minutes of application. According to the report, the medication is a formulated form of the well-known compound known as pilocarpine, and the researchers have developed it to quickly adapt to the pH of the tear film. Also read | How much alcohol to drink at what age? The Lancet study reveals Utilising the eye's natural ability to constrict the pupil, the drop enhances near vision while preserving far vision. The drop is most helpful for people between the ages of 40 and 55, according to the researchers' analysis of two randomised control trials involving 750 participants. Moreover, they did not suffer any severe adverse effects; however, a few patients did report minor headaches and eye redness. (With inputs from agencies) Watch WION LIVE HERE: You can now write for wionews.com and be a part of the community. Share your stories and opinions with us here.

US FDA approves new eye drops that can replace spectacles and fix near-vision

With the rise in the number of heart ailments in the recent future, the need to keep the heart healthy seems to have come to the fore. Along with this, several studies have also come up suggesting ways to diagnose risks to the heart. In one such study, the researchers have found that even a simple non-invasive eye examination can predict the risk of heart attack, media reports said.&nbsp;To identify risk of an attack, the information about the pattern of blood vessels in the retina along with traditional clinical factors can be helpful, the researchers found. It has been found to be better in comparison with the established models, which include only demographic data. &nbsp;

Also Read:&nbsp;<a href="https://www.wionews.com/science/ditch-sedentary-lifestyle-sit-less-move-more-to-reduce-risk-of-stroke-says-study-read-details-here-486801" hreflang="en">Ditch sedentary lifestyle! Sit less, move more to reduce risk of stroke, says study. Read details here</a>

The researchers have used data from UK Biobank to calculate a measure called fractal dimension. The biobank has medical and lifestyle records of over 500,000 people. These professionals then combined it in a model with factors like systolic blood pressure, sex, age, body mass index and smoking status.&nbsp;They studied people in the database who experienced a heart attack or myocardial infarction or MI after their retinal images were collected.&nbsp;These experts will present an abstract about this study at the European Society of Human Genetics annual conference in Vienna on Monday. &nbsp;

Watch | Superfetation: Can a woman get pregnant again while already being pregnant?

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Ana Villaplana-Velasco, PhD student, Usher and Roslin institutes at the University of Edinburgh and the presenting author, said, “Strikingly, we discovered that our model was able to better classify participants with low or high MI risk in UK Biobank when compared with established models that only include demographic data. The improvement of our model was even higher if we added a score related to the genetic propensity of developing MI.” &nbsp;&nbsp;

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“The calculation of an individualised MI risk from those over 50 years old would seem to be appropriate. This would enable doctors to suggest behaviours that could reduce risk, such as giving up smoking and maintaining normal cholesterol and blood pressure,” said Villaplana-Velasco. &nbsp;&nbsp;

(With inputs from agencies)&nbsp;

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With the rise in the number of heart ailments in the recent future, the need to keep the heart healthy seems to have come to the fore. Along with this, several studies have also come up suggesting ways to diagnose risks to the heart.

With the rise in the number of heart ailments in the recent future, the need to keep the heart healthy seems to have come to the fore. Along with this, several studies have also come up suggesting ways to diagnose risks to the heart. In one such study, the researchers have found that even a simple non-invasive eye examination can predict the risk of heart attack, media reports said. To identify risk of an attack, the information about the pattern of blood vessels in the retina along with traditional clinical factors can be helpful, the researchers found. It has been found to be better in comparison with the established models, which include only demographic data. Also Read: Ditch sedentary lifestyle! Sit less, move more to reduce risk of stroke, says study. Read details here The researchers have used data from UK Biobank to calculate a measure called fractal dimension. The biobank has medical and lifestyle records of over 500,000 people. These professionals then combined it in a model with factors like systolic blood pressure, sex, age, body mass index and smoking status. They studied people in the database who experienced a heart attack or myocardial infarction or MI after their retinal images were collected. These experts will present an abstract about this study at the European Society of Human Genetics annual conference in Vienna on Monday. Watch | Superfetation: Can a woman get pregnant again while already being pregnant? Ana Villaplana-Velasco, PhD student, Usher and Roslin institutes at the University of Edinburgh and the presenting author, said, “Strikingly, we discovered that our model was able to better classify participants with low or high MI risk in UK Biobank when compared with established models that only include demographic data. The improvement of our model was even higher if we added a score related to the genetic propensity of developing MI.” WATCH WION LIVE HERE “The calculation of an individualised MI risk from those over 50 years old would seem to be appropriate. This would enable doctors to suggest behaviours that could reduce risk, such as giving up smoking and maintaining normal cholesterol and blood pressure,” said Villaplana-Velasco. (With inputs from agencies) You can now write for wionews.com and be a part of the community. Share your stories and opinions with us here. ×

Even an eye test may be able to predict risk of heart attack, says study

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