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<p>An international research team has found that an increase in nightmares and hallucinations, or 'daymares,' could indicate the onset of autoimmune diseases like lupus.</p>

<p>Lupus, an autoimmune inflammatory disease, impacts multiple organs, including the brain.</p>

<p>According to researchers from the University of Cambridge and King's College London in the UK, mental health and neurological symptoms such as depression, hallucinations, and loss of balance can serve as early warning signs of an impending "flare," a period when the disease worsens.</p>

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<p>In their study, the researchers surveyed 676 people with lupus and 400 clinicians, and conducted in-depth interviews with 69 people suffering from systemic autoimmune rheumatic diseases (including lupus) and 50 clinicians.</p>

<p><a href="https://www.wionews.com/entertainment/lifestyle/news-pregnancy-and-kidney-health-all-you-need-to-know-700328">Also read | Pregnancy and kidney health: All you need to know</a></p>

<p>The findings, published in the journal eClinicalMedicine, revealed that disrupted dream sleep was the most common symptom, experienced by three out of five patients. Among these patients, one-third developed lupus a year later.</p>

<p>Additionally, just under a quarter of the patients reported experiencing hallucinations, which were present in 85 per cent of those with lupus.</p>

<p>Furthermore, three out of five lupus patients and one in three individuals with other rheumatology-related conditions reported increasingly disrupted dream sleep, often vivid and distressing nightmares, shortly before experiencing hallucinations. These nightmares frequently involved scenarios of being attacked, trapped, crushed, or falling.</p>

<p><a href="https://www.wionews.com/india-news/rare-cross-border-kidney-swap-save-lives-of-two-mothers-667882">Also read | ‘Rarest of rare’ kidney swap saves lives of two mothers from India and Tanzania</a></p>

<p>"Patients often know which symptoms are a bad sign that their disease is about to flare, but both patients and doctors can be reluctant to discuss mental health and neurological symptoms, particularly if they don't realise that these can be a part of autoimmune diseases," said Melanie, the lead author from the varsity's Department of Public Health and Primary Care.</p>

<p><em>(With inputs from agencies)</em></p>
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An international research team has found that an increase in nightmares and hallucinations, or 'daymares,' could indicate the onset of autoimmune diseases like lupus.

An international research team has found that an increase in nightmares and hallucinations, or 'daymares,' could indicate the onset of autoimmune diseases like lupus. Lupus, an autoimmune inflammatory disease, impacts multiple organs, including the brain. According to researchers from the University of Cambridge and King's College London in the UK, mental health and neurological symptoms such as depression, hallucinations, and loss of balance can serve as early warning signs of an impending "flare," a period when the disease worsens. In their study, the researchers surveyed 676 people with lupus and 400 clinicians, and conducted in-depth interviews with 69 people suffering from systemic autoimmune rheumatic diseases (including lupus) and 50 clinicians. Also read | Pregnancy and kidney health: All you need to know The findings, published in the journal eClinicalMedicine, revealed that disrupted dream sleep was the most common symptom, experienced by three out of five patients. Among these patients, one-third developed lupus a year later. Additionally, just under a quarter of the patients reported experiencing hallucinations, which were present in 85 per cent of those with lupus. Furthermore, three out of five lupus patients and one in three individuals with other rheumatology-related conditions reported increasingly disrupted dream sleep, often vivid and distressing nightmares, shortly before experiencing hallucinations. These nightmares frequently involved scenarios of being attacked, trapped, crushed, or falling. Also read | ‘Rarest of rare’ kidney swap saves lives of two mothers from India and Tanzania "Patients often know which symptoms are a bad sign that their disease is about to flare, but both patients and doctors can be reluctant to discuss mental health and neurological symptoms, particularly if they don't realise that these can be a part of autoimmune diseases," said Melanie, the lead author from the varsity's Department of Public Health and Primary Care. (With inputs from agencies)

Nightmares, daytime hallucinations could indicate onset of THIS disease

<p>An international team led by scientists at Stanford University has unveiled a potential explanation for the long-standing puzzle of why the majority, about 80 percent, of autoimmune disease patients are women.</p>

<p>The research, published in the journal Cell, identifies a key player: a molecule called Xist, only found in women, which seems to be a major contributor to autoimmune diseases such as lupus and rheumatoid arthritis.</p>

<p>The study revealed that Xist, responsible for silencing one of the X chromosomes in females (XX) to prevent protein from overproducing, also forms molecular complexes linked to autoimmune diseases. While much of the research was conducted in mice, human patients with autoimmune diseases demonstrated a chemical response triggered by Xist complexes.</p>

<p>"Clearly there’s got to be more, because one-tenth of lupus patients are men. So it’s not the only answer, but it’s a very interesting piece of the puzzle," Dr David Karp, Chief of Rheumatic Diseases, UT Southwestern Medical Center said.&nbsp;</p>

<h2><strong>Implications for diagnosis&nbsp;</strong></h2>

<p>Understanding the role of the Xist molecule opens the door to potential advancements in diagnostics and treatments. The discovery may lead to new tests for early detection of autoimmune diseases and, in the long term, innovative therapeutic approaches.</p>

<p>Also Read |&nbsp;<a href="https://www.wionews.com/science/hazardous-asteroid-6-times-wider-than-qutub-minars-height-to-fly-past-earth-on-feb-2-686104">‘Hazardous asteroid’ 6 times wider than Qutub Minar’s height to fly past Earth on Feb 2</a></p>

<p>"The sky’s the limit here. Once you understand the fundamental mechanisms, you could think about developing therapies, early detection, and preventions," Dr. Jeffrey A. Sparks, Brigham and Women’s Hospital said.&nbsp;</p>

<p>While the revelation does not explain how men acquire autoimmune diseases or the gender imbalance in specific conditions like Type 1 diabetes, it marked a significant step toward unraveling the complexities of these illnesses.</p>

<p>Also Read |&nbsp;<a href="https://www.wionews.com/science/using-phone-first-thing-in-morning-can-give-you-headache-for-rest-of-the-day-experts-685975">Using phone first thing in morning can give you headache for rest of the day: Experts</a></p>

<p>"This work takes it in a totally different direction, and says that the mechanism that is needed to turn off the second X chromosome might be responsible for generating autoimmunity." - Dr. David Karp, UT Southwestern Medical Center</p>

<p>While major treatment advances may be years away, the newfound understanding of Xist's role provides hope for progress in managing autoimmune diseases.</p>

<p><strong>Watch |&nbsp;<a href="https://www.wionews.com/videos/gravitas-starbucks-new-brew-infused-with-olive-oil-and-backlash-686118">Gravitas | Starbucks' new brew infused with olive oil and backlash</a></strong></p>

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<p>"We’ve made progress like this study to better understand what it is that triggers it," Stephanie Buxhoeveden, PhD Candidate in Nursing, Managing Multiple Sclerosis said.&nbsp;</p>

<p><em>(With inputs from agencies)</em></p>


An international team led by scientists at Stanford University has unveiled a potential explanation for the long-standing puzzle of why the majority, about 80 percent, of autoimmune disease patients are women.

An international team led by scientists at Stanford University has unveiled a potential explanation for the long-standing puzzle of why the majority, about 80 percent, of autoimmune disease patients are women. The research, published in the journal Cell, identifies a key player: a molecule called Xist, only found in women, which seems to be a major contributor to autoimmune diseases such as lupus and rheumatoid arthritis. The study revealed that Xist, responsible for silencing one of the X chromosomes in females (XX) to prevent protein from overproducing, also forms molecular complexes linked to autoimmune diseases. While much of the research was conducted in mice, human patients with autoimmune diseases demonstrated a chemical response triggered by Xist complexes. "Clearly there’s got to be more, because one-tenth of lupus patients are men. So it’s not the only answer, but it’s a very interesting piece of the puzzle," Dr David Karp, Chief of Rheumatic Diseases, UT Southwestern Medical Center said. Implications for diagnosis Understanding the role of the Xist molecule opens the door to potential advancements in diagnostics and treatments. The discovery may lead to new tests for early detection of autoimmune diseases and, in the long term, innovative therapeutic approaches. Also Read | ‘Hazardous asteroid’ 6 times wider than Qutub Minar’s height to fly past Earth on Feb 2 "The sky’s the limit here. Once you understand the fundamental mechanisms, you could think about developing therapies, early detection, and preventions," Dr. Jeffrey A. Sparks, Brigham and Women’s Hospital said. While the revelation does not explain how men acquire autoimmune diseases or the gender imbalance in specific conditions like Type 1 diabetes, it marked a significant step toward unraveling the complexities of these illnesses. Also Read | Using phone first thing in morning can give you headache for rest of the day: Experts "This work takes it in a totally different direction, and says that the mechanism that is needed to turn off the second X chromosome might be responsible for generating autoimmunity." - Dr. David Karp, UT Southwestern Medical Center While major treatment advances may be years away, the newfound understanding of Xist's role provides hope for progress in managing autoimmune diseases. Watch | Gravitas | Starbucks' new brew infused with olive oil and backlash × "We’ve made progress like this study to better understand what it is that triggers it," Stephanie Buxhoeveden, PhD Candidate in Nursing, Managing Multiple Sclerosis said. (With inputs from agencies)

Massive clue found solving why 80 pc of autoimmune patients are women

<p>Malayalam producer, singer and actress Mamta Mohandas, who&nbsp;was last seen in 'Jana Gana Mana' opposite Prithviraj Sukumaran, took to Instagram on Sunday and revealed that she has been diagnosed with vitiligo. She shared two photos from her home and penned a heartfelt note.</p>

<p>"Dear [sun emoji], I embrace you now like I have never before. So spotted, I’m losing colour. I rise even before you every morning, to see you glimmer your first ray through the haze. Give me all you’ve got. For I will be indebted, here on out and forever by your grace," she wrote and added several&nbsp;hashtags like #vitiligo, #autoimmunedisease, #autoimmune, #faceit, #healing and #fightit to the post.</p>

<p>Check it out below!</p>

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<p><strong>What is&nbsp;Vitiligo?</strong></p>

<p>Vitiligo is&nbsp;a chronic autoimmune disorder that causes patches of skin to lose&nbsp;pigment or colour. It's caused by the lack of melanin and the discoloured areas usually get bigger with time. This skin disorder is most noticeable among people with darker skin as the contrast between normal skin tone and white patches is more pronounced.&nbsp;</p>

<p>In this condition, the melanocytes, present in the skin that make pigments, are attacked and destroyed.</p>

<p>Also read:&nbsp;<a href="https://www.wionews.com/entertainment/jeremy-renners-friends-fear-snowplough-accident-will-leave-actor-crippled-for-life-report-553421">Jeremy Renner's friends fear snowplough accident will leave actor crippled for life: Report</a></p>

<p><strong>Symptoms of&nbsp;Vitiligo </strong></p>

<p>The biggest sign of vitiligo is the appearance of light or depigmented spots on the skin. Other symptoms include:</p>

<ul>
	<li>Hair turning prematurely grey or white</li>
	<li>Eyelashes or eyebrows losing colour</li>
	<li>Change of colour in the retina of the eye</li>
	<li>Colour loss in the nose and mouth</li>
	<li>Inflammation in ears or eyes</li>
</ul>

<p>The exact cause of vitiligo isn't known, but there is a strong connection between this skin condition and genetics or family history. External factors like sunburn, emotional distress and exposure to chemicals can also trigger this condition or make it worse.</p>

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Malayalam producer, singer and actress Mamta Mohandas, who was last seen in 'Jana Gana Mana' opposite Prithviraj Sukumaran, took to Instagram on Sunday and revealed that she has been diagnosed with vitiligo.

Malayalam producer, singer and actress Mamta Mohandas, who was last seen in 'Jana Gana Mana' opposite Prithviraj Sukumaran, took to Instagram on Sunday and revealed that she has been diagnosed with vitiligo. She shared two photos from her home and penned a heartfelt note. "Dear [sun emoji], I embrace you now like I have never before. So spotted, I’m losing colour. I rise even before you every morning, to see you glimmer your first ray through the haze. Give me all you’ve got. For I will be indebted, here on out and forever by your grace," she wrote and added several hashtags like #vitiligo, #autoimmunedisease, #autoimmune, #faceit, #healing and #fightit to the post. Check it out below! View this post on Instagram A post shared by Mamta Mohandas (@mamtamohan) What is Vitiligo? Vitiligo is a chronic autoimmune disorder that causes patches of skin to lose pigment or colour. It's caused by the lack of melanin and the discoloured areas usually get bigger with time. This skin disorder is most noticeable among people with darker skin as the contrast between normal skin tone and white patches is more pronounced. In this condition, the melanocytes, present in the skin that make pigments, are attacked and destroyed. Also read: Jeremy Renner's friends fear snowplough accident will leave actor crippled for life: Report Symptoms of Vitiligo The biggest sign of vitiligo is the appearance of light or depigmented spots on the skin. Other symptoms include: Hair turning prematurely grey or white Eyelashes or eyebrows losing colour Change of colour in the retina of the eye Colour loss in the nose and mouth Inflammation in ears or eyes The exact cause of vitiligo isn't known, but there is a strong connection between this skin condition and genetics or family history. External factors like sunburn, emotional distress and exposure to chemicals can also trigger this condition or make it worse. WATCH WION LIVE HERE You can now write for wionews.com and be a part of the community. Share your stories and opinions with us here.

Malayalam actress Mamta Mohandas diagnosed with vitiligo; What is this autoimmune disease?

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