Weight-loss drugs are poised to revolutionise healthcare by slowing the ageing process and allowing people to live for longer and in better health. That is the dramatic message from leading scientists after studies were presented last week at the European Society of Cardiology Conference in London.

Weight-loss drug Ozempic reveals new benefits like slowing down ageing process

When does ageing start? Is it a gradual process or is there a specific age in which we start to 'suddenly' age? According to a new study, there are two, not one, time periods in our lives when we show sudden signs of ageing.

There is a burst of ageing at 44, and then at 60, accoriding to research done at Stanford University in the US.

This busts the general notion that our bodies and minds decline in a slow process, referred to as 'linear ageing'.

Watch: China's anti-ageing component isolated from blood 
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Earlier, the ageing in 40s was seen as part of onset of menopause in women, but the study has shown that men also show signs of decline in mid-40s onwards.

<h2>How did they reach the conclusion?</h2>

The study published in Nature Ageing journal tracked thousands of different molecules in people aged between 25 and 75.

It found two waves of age-related changes in the molecular composition of bodies: at around ages 44 and again at 60.&nbsp;

The findings could explain "why spikes in certain health issues including musculoskeletal problems and cardiovascular disease occur at certain ages," the researchers said.

Also read: <a href="https://www.wionews.com/science/new-study-reveals-that-your-bodys-cells-age-rapidly-within-a-day-719816">New study reveals that your body's cells age rapidly within a day</a> 
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The researchers call these sudden spurts 'nonlinear' ageing. "The analysis revealed consistent nonlinear patterns in molecular markers of ageing, with substantial dysregulation occurring at two major periods occurring at approximately 44 years and 60 years of chronological age," said the study.&nbsp;

They found cardiovascular disease, lipid and alcohol metabolism changes at the 40-year transition, and shifts in "immune regulation and carbohydrate metabolism" during the 60-year transition.

Also read:&nbsp;<a href="https://www.wionews.com/science/study-shows-strong-links-between-losing-loved-ones-and-ageing-745671">Study shows 'strong links' between losing loved ones and biological ageing</a>

Risk of diseases accelerate at specific points in human lifespan.

The study pointed out that in the US,&nbsp; atherosclerosis, stroke and heart attacks are are up 40% between the ages of 40 and 59. It rises to about 75% between ages 60 and 79 and reaches &nbsp;86% at 80 years and above.

Neurodegenerative diseases like Parkinson’s and Alzheimer’s have distinct "turning points" around the ages of 40 and 65, respectively.

<h2>What is ageing?&nbsp;</h2>

Ageing is the decline in physical and cognitive abilities, as well as changes in&nbsp;appearance such as wrinkling skin. This is also the period in which people suffer from aches and pains, and diseases and wounds take longer to heal.

According to World Health Organization, ageing is on the rise globally.

"In 2019, the number of people aged 60 years and older was 1 billion. This number will increase to 1.4 billion by 2030 and 2.1 billion by 2050," it says on its Ageing website.&nbsp;

(With inputs from agencies)

When does ageing start? Is it a gradual process or is there a specific age in which we start to 'suddenly' age? According to a new study, there are two, not one, time periods in our lives when we show sudden signs of ageing.

When does ageing start? Is it a gradual process or is there a specific age in which we start to 'suddenly' age? According to a new study, there are two, not one, time periods in our lives when we show sudden signs of ageing. There is a burst of ageing at 44, and then at 60, accoriding to research done at Stanford University in the US. This busts the general notion that our bodies and minds decline in a slow process, referred to as 'linear ageing'. Watch: China's anti-ageing component isolated from blood × Earlier, the ageing in 40s was seen as part of onset of menopause in women, but the study has shown that men also show signs of decline in mid-40s onwards. How did they reach the conclusion? The study published in Nature Ageing journal tracked thousands of different molecules in people aged between 25 and 75. It found two waves of age-related changes in the molecular composition of bodies: at around ages 44 and again at 60. The findings could explain "why spikes in certain health issues including musculoskeletal problems and cardiovascular disease occur at certain ages," the researchers said. Also read: New study reveals that your body's cells age rapidly within a day The researchers call these sudden spurts 'nonlinear' ageing. "The analysis revealed consistent nonlinear patterns in molecular markers of ageing, with substantial dysregulation occurring at two major periods occurring at approximately 44 years and 60 years of chronological age," said the study. They found cardiovascular disease, lipid and alcohol metabolism changes at the 40-year transition, and shifts in "immune regulation and carbohydrate metabolism" during the 60-year transition. Also read: Study shows 'strong links' between losing loved ones and biological ageing Risk of diseases accelerate at specific points in human lifespan. The study pointed out that in the US, atherosclerosis, stroke and heart attacks are are up 40% between the ages of 40 and 59. It rises to about 75% between ages 60 and 79 and reaches 86% at 80 years and above. Neurodegenerative diseases like Parkinson’s and Alzheimer’s have distinct "turning points" around the ages of 40 and 65, respectively. What is ageing? Ageing is the decline in physical and cognitive abilities, as well as changes in appearance such as wrinkling skin. This is also the period in which people suffer from aches and pains, and diseases and wounds take longer to heal. According to World Health Organization, ageing is on the rise globally. "In 2019, the number of people aged 60 years and older was 1 billion. This number will increase to 1.4 billion by 2030 and 2.1 billion by 2050," it says on its Ageing website. (With inputs from agencies)

When does ageing really kick in? Scientists find two specific ages when signs show up. They are...

A groundbreaking study led by Integrated Biosciences, a biotechnology company focused on ageing research, has showcased the remarkable potential of artificial intelligence (AI) in discovering novel senolytic compounds.

Senolytics are small molecules that can suppress age-related processes such as inflammation, fibrosis, and cancer. By leveraging AI technology to screen over 800,000 compounds, researchers identified three highly efficient drug candidates that exhibit superior medicinal chemistry properties compared to existing senolytics, according to Earth.com.

<h2>Unlocking the power of AI in drug discovery</h2>

The utilisation of AI in this study marks a significant milestone for longevity research and drug discovery.

By harnessing AI's capabilities to explore chemical space virtually, the researchers at Integrated Bio-sciences have identified multiple promising anti-ageing compounds.

Co-lead author Felix Wong, the co-founder of Integrated Bio-sciences, expressed the significance of these findings and the potential for successful clinical applications.

Also read |&nbsp;<a href="https://www.wionews.com/science/scientists-understood-ancient-shrimp-like-creature-as-predator-says-new-research-613102">Scientists understood ancient shrimp like creature as 'predator', says new research</a>

<h2>Targeting senescent cells for age-related diseases</h2>

Senescent cells play a role in various age-related diseases, including diabetes, cancer, Alzheimer's disease, and cardiovascular disease.

Senolytics selectively induce apoptosis (programmed cell death) in these non-dividing senescent cells. However, previous senolytic compounds faced challenges such as poor bio-availability and undesirable side effects.

The researchers aimed to identify therapeutic interventions that selectively remove senescent cells from the body without harming healthy cells.

Through their AI-driven approach, they discovered three highly selective and potent senolytic compounds.

These compounds exhibit favourable medicinal chemistry properties, increasing their potential for successful clinical outcomes.

Also read |&nbsp;<a href="https://www.wionews.com/science/skip-sleep-increase-risk-of-cognitive-decline-research-warns-middle-aged-people-612689">Skip sleep, increase risk of cognitive decline, research warns middle-aged people</a>

Co-lead author Satotaka Omori, Head of the Ageing Biology department at Integrated Biosciences, expressed optimism about the prospects of these compounds in clinical trials and their potential to restore health in ageing individuals.

To predict the senolytic activity of a wide range of molecules, the scientists trained deep neural networks using experimentally generated data.

Leveraging this machine learning model, they screened over 800,000 compounds and identified three compounds that demonstrated high selectivity and potency as senolytics.

These compounds, which bind to Bcl-2 (a protein regulating apoptosis and a chemotherapy target), also exhibited favourable toxicity profiles in hemolysis and genotoxicity experiments.

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A groundbreaking study led by Integrated Biosciences, a biotechnology company focused on ageing research, has showcased the remarkable potential of artificial intelligence (AI) in discovering novel senolytic compounds.

A groundbreaking study led by Integrated Biosciences, a biotechnology company focused on ageing research, has showcased the remarkable potential of artificial intelligence (AI) in discovering novel senolytic compounds. Senolytics are small molecules that can suppress age-related processes such as inflammation, fibrosis, and cancer. By leveraging AI technology to screen over 800,000 compounds, researchers identified three highly efficient drug candidates that exhibit superior medicinal chemistry properties compared to existing senolytics, according to Earth.com. Unlocking the power of AI in drug discovery The utilisation of AI in this study marks a significant milestone for longevity research and drug discovery. By harnessing AI's capabilities to explore chemical space virtually, the researchers at Integrated Bio-sciences have identified multiple promising anti-ageing compounds. Co-lead author Felix Wong, the co-founder of Integrated Bio-sciences, expressed the significance of these findings and the potential for successful clinical applications. Also read | Scientists understood ancient shrimp like creature as 'predator', says new research Targeting senescent cells for age-related diseases Senescent cells play a role in various age-related diseases, including diabetes, cancer, Alzheimer's disease, and cardiovascular disease. Senolytics selectively induce apoptosis (programmed cell death) in these non-dividing senescent cells. However, previous senolytic compounds faced challenges such as poor bio-availability and undesirable side effects. The researchers aimed to identify therapeutic interventions that selectively remove senescent cells from the body without harming healthy cells. Through their AI-driven approach, they discovered three highly selective and potent senolytic compounds. These compounds exhibit favourable medicinal chemistry properties, increasing their potential for successful clinical outcomes. Also read | Skip sleep, increase risk of cognitive decline, research warns middle-aged people Co-lead author Satotaka Omori, Head of the Ageing Biology department at Integrated Biosciences, expressed optimism about the prospects of these compounds in clinical trials and their potential to restore health in ageing individuals. To predict the senolytic activity of a wide range of molecules, the scientists trained deep neural networks using experimentally generated data. Leveraging this machine learning model, they screened over 800,000 compounds and identified three compounds that demonstrated high selectivity and potency as senolytics. These compounds, which bind to Bcl-2 (a protein regulating apoptosis and a chemotherapy target), also exhibited favourable toxicity profiles in hemolysis and genotoxicity experiments. WATCH WION LIVE HERE:

AI revolutionises ageing research: Leads to discovery of promising anti-ageing compounds

Defying death has been mankind's single biggest wish. Now several companies backed by high-profile big tech founders have joined the hunt to find a solution.

Last year, Amazon founder Jeff Bezos began funding Altos Labs, which is researching on how to reverse the ageing process.&nbsp;

Bezos had declared last year that he would be devoting time to philanthropic activities after stepping down as CEO from the online retail giant. Nobel Prize winner Shinya Yamanaka reportedly joined Alto Labs as chair on the scientific advisory board, signalling the company's intent.

<a href="https://www.wionews.com/world/human-muscle-cells-will-be-sent-to-space-to-study-ageing-438495">Also Read: Human muscle cells will be sent to space to study ageing</a>

The company is reportedly hiring scientists from around the world to work on the anti-ageing process. Reports claim drug developer Hal Barron, 59, will step down as Glaxosmithkline's chief scientific officer to become the chief executive and co-chairman of Altos Labs.

Altos has offices in Silicon Valley and San Diego in California including the UK. The company is aiming to develop technology that can revitalise the cell's in the body affected due to ageing.&nbsp;

Bezos had also invested in Unity Biotechnology which aimed to produce drugs and treat diseases linked to ageing. The company sought to tackle Osteoarthritis opening trail among 40 patients.

<a href="https://www.wionews.com/science/this-diabetes-treatment-can-delay-ageing-among-humans-scientists-claim-368759">Also Read:&nbsp;This diabetes treatment can delay ageing among humans, scientists claim</a>

According to research, the number of older people in the US by 2035 will be more than 18-year-olds in the country.

Google founder Larry Page and Facebook's Mark Zuckerberg have also put money into anti-ageing research to slow down and delay old age.

(With inputs from Agencies)

Defying death has been mankind's single biggest wish. Now several companies backed by high-profile big tech founders have joined the hunt to find a solution. Last year, Amazon founder Jeff Bezos began funding Altos Labs, which is researching on how to reverse the ageing process.

Defying death has been mankind's single biggest wish. Now several companies backed by high-profile big tech founders have joined the hunt to find a solution. Last year, Amazon founder Jeff Bezos began funding Altos Labs, which is researching on how to reverse the ageing process. Bezos had declared last year that he would be devoting time to philanthropic activities after stepping down as CEO from the online retail giant. Nobel Prize winner Shinya Yamanaka reportedly joined Alto Labs as chair on the scientific advisory board, signalling the company's intent. Also Read: Human muscle cells will be sent to space to study ageing The company is reportedly hiring scientists from around the world to work on the anti-ageing process. Reports claim drug developer Hal Barron, 59, will step down as Glaxosmithkline's chief scientific officer to become the chief executive and co-chairman of Altos Labs. Altos has offices in Silicon Valley and San Diego in California including the UK. The company is aiming to develop technology that can revitalise the cell's in the body affected due to ageing. Bezos had also invested in Unity Biotechnology which aimed to produce drugs and treat diseases linked to ageing. The company sought to tackle Osteoarthritis opening trail among 40 patients. Also Read: This diabetes treatment can delay ageing among humans, scientists claim According to research, the number of older people in the US by 2035 will be more than 18-year-olds in the country. Google founder Larry Page and Facebook's Mark Zuckerberg have also put money into anti-ageing research to slow down and delay old age. (With inputs from Agencies)

Defying death: Jeff Bezos, other big tech founders fund startups doing anti-aging research

Ageing underlines the fatalist truth about being human. But scientists around the world are working on ways to stop, or at least slowing down the process. An increasing number of scientists believe that a treatment for Type 2 diabetes may help in slowing down ageing, The Washington Post first reported.

The treatment called "metformin" is helpful is reportedly slowing down multiple age-related ailments, including heart disease, dementia, and cancer.&nbsp;

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If true, metformin can not just fight these diseases, but also potentially extend our lifespan. But immortality is still light years away!

Nir Barzilai, Director of the Institute for Aging Research, Albert Einstein College of Medicine told the Washington Post that they haven't found the "fountain of youth", but instead claim to delay ageing.

A group of scientists met in Spain in 2014 to find ways to counter ageing. In the aftermath of this meeting, a six-year clinical trial called "Targeting Aging with Metformin" (TAME) was proposed.&nbsp;

Also read:&nbsp;<a href="http://13.235.153.162/science/israeli-scientists-go-backward-in-time-by-successfully-reversing-ageing-by-25-years-344816" hreflang="en">Israeli scientists go 'backward in time' by successfully reversing ageing by 25 years</a>

The trial intends to dig deeper into the anti-ageing techniques of metformin, and will involve at least 3,000 subjects aged between 65-79. It will take place across 14 research sites situated in universities spread across the US, TAME's website claims.

Scientists took up TAME after seeing encouraging results involving metformin. The study is currently in its infancy stage, with more research expected to shed light on the role of metformin in delaying ageing.

Also read:&nbsp;<a href="http://13.235.153.162/world/regular-intake-of-junk-food-can-affect-chromosomes-related-to-ageing-study-324492" hreflang="en">Regular intake of junk food can affect chromosomes related to ageing: Study</a> 
 
Earlier, Israeli scientists claimed they had also reversed signs of ageing. Scientists at Tel Aviv University and the Shamir Medical Center claimed to have not only stop ageing, but to reverse it by administering oxygen at high-pressure levels in a chamber. &nbsp;According to Al Jazeera, it reversed two processes associated with ageing and illness

Ageing underlines the fatalist truth about being human. But scientists around the world are working on ways to stop, or at least slowing down the process. An increasing number of scientists believe that a treatment for Type 2 diabetes may help in slowing down ageing, The Washington Post first reported.

Ageing underlines the fatalist truth about being human. But scientists around the world are working on ways to stop, or at least slowing down the process. An increasing number of scientists believe that a treatment for Type 2 diabetes may help in slowing down ageing, The Washington Post first reported. The treatment called "metformin" is helpful is reportedly slowing down multiple age-related ailments, including heart disease, dementia, and cancer. If true, metformin can not just fight these diseases, but also potentially extend our lifespan. But immortality is still light years away! Nir Barzilai, Director of the Institute for Aging Research, Albert Einstein College of Medicine told the Washington Post that they haven't found the "fountain of youth", but instead claim to delay ageing. A group of scientists met in Spain in 2014 to find ways to counter ageing. In the aftermath of this meeting, a six-year clinical trial called "Targeting Aging with Metformin" (TAME) was proposed. Also read: Israeli scientists go 'backward in time' by successfully reversing ageing by 25 years The trial intends to dig deeper into the anti-ageing techniques of metformin, and will involve at least 3,000 subjects aged between 65-79. It will take place across 14 research sites situated in universities spread across the US, TAME's website claims. Scientists took up TAME after seeing encouraging results involving metformin. The study is currently in its infancy stage, with more research expected to shed light on the role of metformin in delaying ageing. Also read: Regular intake of junk food can affect chromosomes related to ageing: Study Earlier, Israeli scientists claimed they had also reversed signs of ageing. Scientists at Tel Aviv University and the Shamir Medical Center claimed to have not only stop ageing, but to reverse it by administering oxygen at high-pressure levels in a chamber. According to Al Jazeera, it reversed two processes associated with ageing and illness

This diabetes treatment can delay ageing among humans, scientists claim

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