<p>An immunotherapy drug, pembrolizumab, has shown the potential to "melt away" tumours in bowel cancer patients, as per a new&nbsp;study. It is seen to have boosted cure rates and also potentially eliminate the need for surgery, according to recent clinical trial results.</p>

<p>Pembrolizumab, also known as Keytruda, works by targeting and blocking a specific protein in immune cells. It enabled them to identify and destroy cancer cells.</p>

<p>This new approach, administered before surgery instead of chemotherapy, has yielded remarkable results.</p>

<p>Presented at the American Society of Clinical Oncology (ASCO) conference, the study found a substantial increase in patients achieving cancer-free status.</p>

<p>Also Read |&nbsp;<a href="https://www.wionews.com/science/ozempic-shows-promise-beyond-diabetes-new-study-reveals-kidney-benefits-728066">Ozempic shows promise beyond diabetes: New study reveals kidney benefits</a></p>

<p>Led by researchers from University College London, University College London Hospital, the Christie NHS Foundation Trust in Manchester, St. James’s University Hospital in Leeds, University Hospital Southampton, and the University of Glasgow, the trial was funded by Merck Sharp and Dohme and included 32 patients with stage two or three bowel cancer and a specific genetic profile (MMR deficient/MSI-High bowel cancer).</p>

<p>Also Read |&nbsp;<a href="https://www.wionews.com/science/blood-test-predicts-breast-cancer-recurrence-years-in-advance-728065">Blood test predicts breast cancer recurrence years in advance</a></p>

<p>The trial results were described as "really very exciting" by Professor Mark Saunders, a consultant clinical oncologist at the Christie.</p>

<p>"Immunotherapy prior to surgery could well become a 'gamechanger' for these patients with this type of cancer. Not only is the outcome better, but it saves patients from having more conventional chemotherapy, which often has more side-effects. In the future, immunotherapy may even replace the need for surgery."</p>

<p>Bowel cancer is a significant global health issue, being the second leading cause of cancer-related deaths worldwide with over 1.9 million new cases and more than 900,000 deaths annually, according to the World Health Organization.</p>

<p><strong>Watch | Gravitas: Japanese researchers closer to make biological clock irrelevant</strong></p>

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<h2><strong>Trial&nbsp;</strong></h2>

<p>During the trial, patients received pembrolizumab for nine weeks before surgery, bypassing the traditional chemotherapy route. The results were striking. About 59 per cent of patients had no signs of cancer following the treatment, while the remaining 41 per cent had their cancer surgically removed.</p>

<p>All patients in the trial were cancer-free post-treatment.&nbsp;</p>

<p>Dr. Kai-Keen Shiu, the trial’s chief investigator highlighted the drug’s efficacy saying, "Our results indicate that pembrolizumab is a safe and highly effective treatment to improve outcomes in patients with high-risk bowel cancers, increasing the chances of curing the disease at an early stage."</p>

<p>He noted that while the initial results are promising, long-term follow-up is necessary to confirm the durability of the response.</p>

<p><em>(With inputs from agencies)</em></p>


An immunotherapy drug, pembrolizumab, has shown the potential to "melt away" tumours in bowel cancer patients, as per a new study. It is seen to have boosted cure rates and also potentially eliminate the need for surgery, according to recent clinical trial results.

An immunotherapy drug, pembrolizumab, has shown the potential to "melt away" tumours in bowel cancer patients, as per a new study. It is seen to have boosted cure rates and also potentially eliminate the need for surgery, according to recent clinical trial results. Pembrolizumab, also known as Keytruda, works by targeting and blocking a specific protein in immune cells. It enabled them to identify and destroy cancer cells. This new approach, administered before surgery instead of chemotherapy, has yielded remarkable results. Presented at the American Society of Clinical Oncology (ASCO) conference, the study found a substantial increase in patients achieving cancer-free status. Also Read | Ozempic shows promise beyond diabetes: New study reveals kidney benefits Led by researchers from University College London, University College London Hospital, the Christie NHS Foundation Trust in Manchester, St. James’s University Hospital in Leeds, University Hospital Southampton, and the University of Glasgow, the trial was funded by Merck Sharp and Dohme and included 32 patients with stage two or three bowel cancer and a specific genetic profile (MMR deficient/MSI-High bowel cancer). Also Read | Blood test predicts breast cancer recurrence years in advance The trial results were described as "really very exciting" by Professor Mark Saunders, a consultant clinical oncologist at the Christie. "Immunotherapy prior to surgery could well become a 'gamechanger' for these patients with this type of cancer. Not only is the outcome better, but it saves patients from having more conventional chemotherapy, which often has more side-effects. In the future, immunotherapy may even replace the need for surgery." Bowel cancer is a significant global health issue, being the second leading cause of cancer-related deaths worldwide with over 1.9 million new cases and more than 900,000 deaths annually, according to the World Health Organization. Watch | Gravitas: Japanese researchers closer to make biological clock irrelevant × Trial During the trial, patients received pembrolizumab for nine weeks before surgery, bypassing the traditional chemotherapy route. The results were striking. About 59 per cent of patients had no signs of cancer following the treatment, while the remaining 41 per cent had their cancer surgically removed. All patients in the trial were cancer-free post-treatment. Dr. Kai-Keen Shiu, the trial’s chief investigator highlighted the drug’s efficacy saying, "Our results indicate that pembrolizumab is a safe and highly effective treatment to improve outcomes in patients with high-risk bowel cancers, increasing the chances of curing the disease at an early stage." He noted that while the initial results are promising, long-term follow-up is necessary to confirm the durability of the response. (With inputs from agencies)

THIS immunotherapy drug could revolutionise bowel cancer treatment

<p>A rare discovery of an ovarian tumour was made by archaeologists while excavating an ancient Egyptian cemetery. The tumour was present in the pelvis of an Egyptian woman who was buried more than three millennia ago.<br />
<br />
The tumour, which was a bony mass and included two teeth, is being seen as teratoma's oldest known example. Teratoma is a rare type of tumour which typically grows in testicles or ovaries.<br />
<br />
As per the Cleveland Clinic, a teratoma can be malignant or benign, and usually, it is filled with various tissues like hair, teeth, muscle or bone.<br />
<br />
Teratomas can lead to swelling and cause pain and can even trigger infection if ruptured. In today's time, the mass gets removed through a typical treatment.</p>

<p><strong>ALSO READ |&nbsp;</strong><a href="https://www.wionews.com/science/worlds-oldest-known-burial-site-was-not-created-by-humans-but-654809">World's oldest known burial site was not created by humans but...</a></p>

<p>Till now, archaeologists have found only four archaeological examples of teratomas, out of which three were in Europe and one was found in Peru. The latest teratoma discovered in the New Kingdom period cemetery in Amarna, Egypt, is the fifth archaeological case published so far.</p>

<h2><strong>Oldest-ever teratoma found in Africa, first such case for the continent</strong></h2>

<p>This is also the oldest known example of a teratoma and the first such case discovered in Africa. The archaeologists investigated four large cemeteries, related to Amarna.<br />
<br />
In one of the tombs present in the North Desert Cemetery, which consisted of a burial chamber and a shaft, the skeleton of a young woman was found by the researchers.<br />
<br />
The skeleton was wrapped in a plant fibre mat and it was buried along with various grave goods, which included a deity related to childbirth, a ring decorated with the figure of Bes, fertility and protection.<br />
<br />
While excavating, the archaeologists came across a bony mass in the woman's pelvis which had deformed teeth in two depressions.<br />
<br />
Southern Illinois University Carbondale's bioarchaeologist Gretchen Dabbs published the tumour's discovery in the International Journal of Paleopathology.</p>

<p><strong>WATCH |&nbsp;Israel-Palestine War: Dozens buried in a mass grave in Gaza city</strong></p>

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<p>After ruling out other diagnoses, the bioarchaeologist and his team suggested that the presence of teeth within the pelvic region of the woman suggested that it was an ovarian teratoma.<br />
<br />
The Bes ring hinted at the teratoma being symptomatic since the "magico-medical" object was kept in the left hand of the woman, which was folded across the woman's lap above the teratoma.<br />
<br />
This meant that the woman "was attempting to invoke Bes to protect her from pain or other symptoms, or aid in her attempts to conceive and birth a child," the researchers wrote in their study.<br />
<br />
"By 18-21 years, this individual probably would have been someone's wife," said Dabbs, while speaking to Live Science, but added that there is also "little doubt she was working in some fashion."</p>

<p><em>(With inputs from agencies)</em></p>


A rare discovery of an ovarian tumour was made by archaeologists while excavating an ancient Egyptian cemetery. The tumour was present in the pelvis of an Egyptian woman who was buried more than three millennia ago.

A rare discovery of an ovarian tumour was made by archaeologists while excavating an ancient Egyptian cemetery. The tumour was present in the pelvis of an Egyptian woman who was buried more than three millennia ago. The tumour, which was a bony mass and included two teeth, is being seen as teratoma's oldest known example. Teratoma is a rare type of tumour which typically grows in testicles or ovaries. As per the Cleveland Clinic, a teratoma can be malignant or benign, and usually, it is filled with various tissues like hair, teeth, muscle or bone. Teratomas can lead to swelling and cause pain and can even trigger infection if ruptured. In today's time, the mass gets removed through a typical treatment. ALSO READ | World's oldest known burial site was not created by humans but... Till now, archaeologists have found only four archaeological examples of teratomas, out of which three were in Europe and one was found in Peru. The latest teratoma discovered in the New Kingdom period cemetery in Amarna, Egypt, is the fifth archaeological case published so far. Oldest-ever teratoma found in Africa, first such case for the continent This is also the oldest known example of a teratoma and the first such case discovered in Africa. The archaeologists investigated four large cemeteries, related to Amarna. In one of the tombs present in the North Desert Cemetery, which consisted of a burial chamber and a shaft, the skeleton of a young woman was found by the researchers. The skeleton was wrapped in a plant fibre mat and it was buried along with various grave goods, which included a deity related to childbirth, a ring decorated with the figure of Bes, fertility and protection. While excavating, the archaeologists came across a bony mass in the woman's pelvis which had deformed teeth in two depressions. Southern Illinois University Carbondale's bioarchaeologist Gretchen Dabbs published the tumour's discovery in the International Journal of Paleopathology. WATCH | Israel-Palestine War: Dozens buried in a mass grave in Gaza city After ruling out other diagnoses, the bioarchaeologist and his team suggested that the presence of teeth within the pelvic region of the woman suggested that it was an ovarian teratoma. The Bes ring hinted at the teratoma being symptomatic since the "magico-medical" object was kept in the left hand of the woman, which was folded across the woman's lap above the teratoma. This meant that the woman "was attempting to invoke Bes to protect her from pain or other symptoms, or aid in her attempts to conceive and birth a child," the researchers wrote in their study. "By 18-21 years, this individual probably would have been someone's wife," said Dabbs, while speaking to Live Science, but added that there is also "little doubt she was working in some fashion." (With inputs from agencies)

Rare discovery: Tumour with teeth found in 3,000-year-old Egyptian burial

<p>A recent study into lung cancers has left researchers baffled as the key findings show that the tumour cells have almost "almost infinite" to evolve and survive, as per reports which also added that a universal cure for the disease is not likely to be in sight any sooner.</p>

<p>While the study said that even as one should not pin their hopes on a universal cure for cancer, there is a greater need to shift attention to preventive measures.&nbsp;</p>

<p>Also Read | <a href="https://www.wionews.com/world/imran-khan-bushra-bibis-marriage-not-as-per-shariah-law-cleric-581906">Imran Khan, Bushra Bibi's marriage not as per Shariah law: Cleric</a></p>

<p>As per Cancer Research UK, cancer must be detected when it is in an early stage. Under the title, TracerX, the analysis talks about the evolution of cancer and its causes.&nbsp;</p>

<p>It is pertinent to note that cancer cells can mutate and is ever-changing. These cells can reach a state where it becomes more aggressive and dodge the immune system. It further spread itself in different parts of the body.&nbsp;</p>

<p>The research was conducted on lung cancer patients, however, it purportedly applies to all types of cancers. For the study, biopsies for over 400 people who are treated at 13 UK hospitals, were taken from different parts of their lung cancer.&nbsp;</p>

<p>Also Read | <a href="https://www.wionews.com/world/world-bank-announces-grant-of-200-million-to-repair-ukraines-energy-infrastructure-581892">World Bank announces grant of $200 million to repair Ukraine's energy infrastructure</a></p>

<p>Professor Charles Swanton from the Francis Crick Institute and University College London said, "That has never been done before at this scale."&nbsp;</p>

<p>"I don't want to sound too depressing about this, but I think - given the almost infinite possibilities in which a tumour can evolve, and the very large number of cells in a late-stage tumour, which could be several hundred billion cells - then achieving cures in all patients with late-stage disease is a formidable task."</p>

<p><strong>Watch | Prince Harry to attend King Charles Coronation without wife Meghan</strong></p>

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<p>Professor Swanton said he does not think the universal cures is going to be able to come up by medical research any time soon. "If we want to make the biggest impact we need to focus on prevention, early detection and early detection of relapse," Swanton added.</p>

<p>Further shedding light on the types of cancers, the study suggests that tumours which demonstrate higher levels of genetic "chaos" were more likely to relapse after surgery to other parts of the body.&nbsp;One of the reasons that the study provides is that cellular machinery can get corrupted and make the cells more aggressive.&nbsp;</p>

<p>Head of prevention and early detection at Cancer Research UK Dr David Crosby said, "The exciting results emerging from TracerX improve our understanding that cancer is a disease which evolves as it progresses, meaning that late-stage cancers can become very hard to treat successfully."</p>

<p>"This underscores the crucial importance of further research to help us to detect cancers at the earliest stages of their development or even better, to prevent them from happening at all."</p>

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A recent study into lung cancers has left researchers baffled as the key findings show that the tumour cells have almost "almost infinite" to evolve and survive, as per reports which also added that a universal cure for the disease is not likely to be in sight any sooner.

A recent study into lung cancers has left researchers baffled as the key findings show that the tumour cells have almost "almost infinite" to evolve and survive, as per reports which also added that a universal cure for the disease is not likely to be in sight any sooner. While the study said that even as one should not pin their hopes on a universal cure for cancer, there is a greater need to shift attention to preventive measures. Also Read | Imran Khan, Bushra Bibi's marriage not as per Shariah law: Cleric As per Cancer Research UK, cancer must be detected when it is in an early stage. Under the title, TracerX, the analysis talks about the evolution of cancer and its causes. It is pertinent to note that cancer cells can mutate and is ever-changing. These cells can reach a state where it becomes more aggressive and dodge the immune system. It further spread itself in different parts of the body. The research was conducted on lung cancer patients, however, it purportedly applies to all types of cancers. For the study, biopsies for over 400 people who are treated at 13 UK hospitals, were taken from different parts of their lung cancer. Also Read | World Bank announces grant of $200 million to repair Ukraine's energy infrastructure Professor Charles Swanton from the Francis Crick Institute and University College London said, "That has never been done before at this scale." "I don't want to sound too depressing about this, but I think - given the almost infinite possibilities in which a tumour can evolve, and the very large number of cells in a late-stage tumour, which could be several hundred billion cells - then achieving cures in all patients with late-stage disease is a formidable task." Watch | Prince Harry to attend King Charles Coronation without wife Meghan × Professor Swanton said he does not think the universal cures is going to be able to come up by medical research any time soon. "If we want to make the biggest impact we need to focus on prevention, early detection and early detection of relapse," Swanton added. Further shedding light on the types of cancers, the study suggests that tumours which demonstrate higher levels of genetic "chaos" were more likely to relapse after surgery to other parts of the body. One of the reasons that the study provides is that cellular machinery can get corrupted and make the cells more aggressive. Head of prevention and early detection at Cancer Research UK Dr David Crosby said, "The exciting results emerging from TracerX improve our understanding that cancer is a disease which evolves as it progresses, meaning that late-stage cancers can become very hard to treat successfully." "This underscores the crucial importance of further research to help us to detect cancers at the earliest stages of their development or even better, to prevent them from happening at all." WATCH WION LIVE HERE You can now write for wionews.com and be a part of the community. Share your stories and opinions with us here.

Universal cure for cancer not anytime soon, tumours have 'almost infinite' ability to evolve: Research

There has been a crucial breakthrough in the fight against the cancer. A trial was carried out at a cancer center in New York. Patients were injected with a drug, and after 6 months, cancer tumors vanished in all patients.

Medical Miracle: After 6 months, Cancer vanished in all patients

tumor

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