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In a ground-breaking study, the researchers claimed to have found a new therapeutic which was developed from compounds found in the blood of the pig and can reverse the age of rats.

The anti-ageing therapeutic, which is called E5, was developed using a young pig’s blood and was injected into the bodies of ageing rats, as per a new study published recently in the journal GeroScience.

E5, which is filled with young plasmas and complex nanoparticles sourced from pigs, can reverse the rats’ biological clocks by nearly 70 per cent on average, stated the researchers, which included those from the University of California, Los Angeles (UCLA).

<h2>Can human age be reversed?</h2>

The scientists claimed that if the same results are achieved in humans, it will mean that an 80-year-old’s age can be reversed to 26.

“Initially, I could hardly believe the profound epigenetic rejuvenation effects of E5. However, our findings are robustly supported by parallel rodent studies from different labs,” said study co-author Steve Horvath, in a statement.

ALSO READ |&nbsp;<a href="https://www.wionews.com/science/a-rat-remembers-research-reveals-how-rodents-have-memory-of-places-they-go-to-654749">A rat remembers: Research reveals how rodents have memory of places they go to</a>

The scientists in the research discovered that when the different rat tissues went under pig blood treatment, it was observed that the biological age of the blood, heart and liver was reversed.

“The treatment more than halved the epigenetic ages of blood, heart, and liver tissue,” wrote the scientists, in the study. They also observed a “less pronounced, but statistically significant” rejuvenation effect on the hypothalamus of the brain.

Researchers stated that they observed “progressive improvement” in the functioning of these organs in the rats and also saw cognitive and behavioural improvements.

<h2>Does the study hint at a major development in future?</h2>

The findings overall suggested a young porcine plasma-derived treatment that “markedly reverses ageing” in rats. “We found the plasma fraction treatment consistently effective in both male and female rats, drastically reducing the epigenetic age of multiple rat tissues,” researchers stated.

The results derived from the new study also give insights into the shared biological mechanisms across mammal species. Although the treatment has not gone through human trials, the researchers still hope that there is room for optimism.

WATCH |&nbsp;New research reveals that rats have the ability to imagine

<div class="videoWrapper trancodeVideo"><iframe allowfullscreen="" autoplay="1" class="includeVideo" frameborder="0" height="350" src="https://www.wionews.com/videos/new-research-reveals-that-rats-have-the-ability-to-imagine-654740/embed" style="width:100%;max-width:560px;" width="560"></iframe></div>

The study hints at a future possibility of using rejuvenation for systemically reducing disease onset risk “rather than treating diseases individually”.

However, scientists have also emphasised how the markers of ageing which were observed in the rats in the study can significantly differ in patterns and values compared to humans.

“What may be detrimental in one species could be inconsequential in another,” the scientists said.

(With inputs from agencies)&nbsp;

In a ground-breaking study, the researchers claimed to have found a new therapeutic which was developed from compounds found in the blood of the pig and can reverse the age of rats.

In a ground-breaking study, the researchers claimed to have found a new therapeutic which was developed from compounds found in the blood of the pig and can reverse the age of rats. The anti-ageing therapeutic, which is called E5, was developed using a young pig’s blood and was injected into the bodies of ageing rats, as per a new study published recently in the journal GeroScience. E5, which is filled with young plasmas and complex nanoparticles sourced from pigs, can reverse the rats’ biological clocks by nearly 70 per cent on average, stated the researchers, which included those from the University of California, Los Angeles (UCLA). Can human age be reversed? The scientists claimed that if the same results are achieved in humans, it will mean that an 80-year-old’s age can be reversed to 26. “Initially, I could hardly believe the profound epigenetic rejuvenation effects of E5. However, our findings are robustly supported by parallel rodent studies from different labs,” said study co-author Steve Horvath, in a statement. ALSO READ | A rat remembers: Research reveals how rodents have memory of places they go to The scientists in the research discovered that when the different rat tissues went under pig blood treatment, it was observed that the biological age of the blood, heart and liver was reversed. “The treatment more than halved the epigenetic ages of blood, heart, and liver tissue,” wrote the scientists, in the study. They also observed a “less pronounced, but statistically significant” rejuvenation effect on the hypothalamus of the brain. Researchers stated that they observed “progressive improvement” in the functioning of these organs in the rats and also saw cognitive and behavioural improvements. Does the study hint at a major development in future? The findings overall suggested a young porcine plasma-derived treatment that “markedly reverses ageing” in rats. “We found the plasma fraction treatment consistently effective in both male and female rats, drastically reducing the epigenetic age of multiple rat tissues,” researchers stated. The results derived from the new study also give insights into the shared biological mechanisms across mammal species. Although the treatment has not gone through human trials, the researchers still hope that there is room for optimism. WATCH | New research reveals that rats have the ability to imagine The study hints at a future possibility of using rejuvenation for systemically reducing disease onset risk “rather than treating diseases individually”. However, scientists have also emphasised how the markers of ageing which were observed in the rats in the study can significantly differ in patterns and values compared to humans. “What may be detrimental in one species could be inconsequential in another,” the scientists said. (With inputs from agencies)

Age-reversal possible? Study finds new compound in pig’s blood which reverses age in rats

In what can be called a major breakthrough in reversal of ageing process, scientists have safely rejuvenated tissues in middle-aged mice. &nbsp;

Researchers in the US have treated healthy animals with a form of gene therapy to refresh older cells. It has helped in making the animals more youthful, as per biological markers used to measure the effects of ageing. &nbsp;

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Although it is still far from being tried on humans, the findings can fuel interest in radical new therapies, which look to slow or reverse the ageing process. It can also be used as a means of tackling age-related diseases, such as cancer, Alzheimer’s, etc. &nbsp;

The findings of the study have been published in the ‘Nature Aging’ journal. &nbsp;

Also Read:&nbsp;<a href="https://www.wionews.com/science/cutting-back-on-final-drink-of-day-can-help-improve-brain-health-says-study-459177" hreflang="en">Cutting back on final drink of day can help improve brain health, says study</a>

The US scientists drew on previous work by the Japanese Nobel laureate Prof Shinya Yamanaka. He had shown that a mixture of four molecules, which are known as Yamanaka factors, can rewind adult cells into youthful stem cells capable of forming almost any tissue in the body. &nbsp;

The US team, which was led by Jasper and Prof Juan Carlos Izpisua Belmonte at the Salk Institute in California and the San Diego Altos Institute, found that mice, who received Yamanaka factors for several months resembled younger animals in many ways. The skin and kidneys, in particular, showed signs of rejuvenation. &nbsp;

(With inputs from agencies)&nbsp;

In what can be called a major breakthrough in reversal of ageing process, scientists have safely rejuvenated tissues in middle-aged mice. Researchers in the US have treated healthy animals with a form of gene therapy to refresh older cells.

In what can be called a major breakthrough in reversal of ageing process, scientists have safely rejuvenated tissues in middle-aged mice. Researchers in the US have treated healthy animals with a form of gene therapy to refresh older cells. It has helped in making the animals more youthful, as per biological markers used to measure the effects of ageing. Also Read: New explosive shock waves-driven rocket engine developed, say scientists Although it is still far from being tried on humans, the findings can fuel interest in radical new therapies, which look to slow or reverse the ageing process. It can also be used as a means of tackling age-related diseases, such as cancer, Alzheimer’s, etc. The findings of the study have been published in the ‘Nature Aging’ journal. Also Read: Cutting back on final drink of day can help improve brain health, says study The US scientists drew on previous work by the Japanese Nobel laureate Prof Shinya Yamanaka. He had shown that a mixture of four molecules, which are known as Yamanaka factors, can rewind adult cells into youthful stem cells capable of forming almost any tissue in the body. The US team, which was led by Jasper and Prof Juan Carlos Izpisua Belmonte at the Salk Institute in California and the San Diego Altos Institute, found that mice, who received Yamanaka factors for several months resembled younger animals in many ways. The skin and kidneys, in particular, showed signs of rejuvenation. (With inputs from agencies)

Breakthrough in ageing reversal? US scientists rejuvenate tissues in mice

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