<p>Europe's drugs regulator has informed BBC News that it is carrying out a review of a few weight-loss jabs after it was alerted about the possibility of them leading to suicide and self-harm among users.<br />
<br />
The European Medicines Agency (EMA) was notified about the development by member state Iceland after three cases emerged.<br />
<br />
The safety assessment will investigate Wegovy, Saxenda and similar drugs like Ozempic that help in curbing appetite. Suicidal thoughts have already been listed on the product leaflets as a possible side effect.</p>

<p><strong>ALSO READ |&nbsp;</strong><a href="https://www.wionews.com/entertainment/lifestyle/news-how-indias-cosmetic-treatment-sector-is-boosting-medical-tourism-612962">How India's cosmetic treatment sector is boosting medical tourism</a></p>

<p>The EMA's Pharmacovigilance Risk Assessment Committee (PRAC), which has been carrying out the review, will look into if other treatments in the same broader category of medicines, glucagon-like peptide-1 (GLP-1) receptor agonists also require assessment.<br />
<br />
However, initially, it will only look into the risks of using weight-loss medication which contains either liraglutide or semaglutide.<br />
<br />
"The review is being carried out in the context of a signal procedure raised by the Icelandic Medicines Agency, following three case reports. A signal is an information on a new or known adverse event that is potentially caused by a medicine and that warrants further investigation,” an EMA official said.<br />
<br />
"The case reports included two cases of suicidal thoughts - one following the use of Saxenda and one after Ozempic. One additional case reported thoughts of self-injury with Saxenda. The EMA will communicate further when more information becomes available,” he added.</p>

<h2><strong>Social media popularising weight-loss treatment</strong></h2>

<p>Such types of treatment have been in great demand in the market because they have been popularised by social media that talk about people, often celebrities, losing large amounts of weight.<br />
<br />
Saxenda and Wegovy have received approval and are licensed for weight loss. Wegovy is still not available in the UK market, however, the prime minister has said GPs may soon start giving it to some patients in England.<br />
<br />
Thoughts of suicide and depression have been listed in the product-information leaflet which advises users: "You should pay attention to any mental changes, especially sudden changes in your mood, behaviours, thoughts, or feelings. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you."</p>

<p><strong>WATCH |&nbsp;Gravitas: Eating faeces can cure your medical condition?</strong></p>

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<p>A representative of manufacturer Novo Nordisk said, "GLP-1 receptor agonists have been used to treat type-2 diabetes for more than 15 years and for treatment of obesity for eight years, including Novo Nordisk products such as semaglutide and liraglutide that have been in the UK market since 2018 and 2009, respectively.”<br />
<br />
"The safety data collected from large clinical-trial programmes and post-marketing surveillance have not demonstrated a causal association between semaglutide or liraglutide and suicidal and self-harming thoughts,” he added.&nbsp;</p>

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Europe's drugs regulator has informed BBC News that it is carrying out a review of a few weight-loss jabs after it was alerted about the possibility of them leading to suicide and self-harm among users.

Europe's drugs regulator has informed BBC News that it is carrying out a review of a few weight-loss jabs after it was alerted about the possibility of them leading to suicide and self-harm among users. The European Medicines Agency (EMA) was notified about the development by member state Iceland after three cases emerged. The safety assessment will investigate Wegovy, Saxenda and similar drugs like Ozempic that help in curbing appetite. Suicidal thoughts have already been listed on the product leaflets as a possible side effect. ALSO READ | How India's cosmetic treatment sector is boosting medical tourism The EMA's Pharmacovigilance Risk Assessment Committee (PRAC), which has been carrying out the review, will look into if other treatments in the same broader category of medicines, glucagon-like peptide-1 (GLP-1) receptor agonists also require assessment. However, initially, it will only look into the risks of using weight-loss medication which contains either liraglutide or semaglutide. "The review is being carried out in the context of a signal procedure raised by the Icelandic Medicines Agency, following three case reports. A signal is an information on a new or known adverse event that is potentially caused by a medicine and that warrants further investigation,” an EMA official said. "The case reports included two cases of suicidal thoughts - one following the use of Saxenda and one after Ozempic. One additional case reported thoughts of self-injury with Saxenda. The EMA will communicate further when more information becomes available,” he added. Social media popularising weight-loss treatment Such types of treatment have been in great demand in the market because they have been popularised by social media that talk about people, often celebrities, losing large amounts of weight. Saxenda and Wegovy have received approval and are licensed for weight loss. Wegovy is still not available in the UK market, however, the prime minister has said GPs may soon start giving it to some patients in England. Thoughts of suicide and depression have been listed in the product-information leaflet which advises users: "You should pay attention to any mental changes, especially sudden changes in your mood, behaviours, thoughts, or feelings. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you." WATCH | Gravitas: Eating faeces can cure your medical condition? A representative of manufacturer Novo Nordisk said, "GLP-1 receptor agonists have been used to treat type-2 diabetes for more than 15 years and for treatment of obesity for eight years, including Novo Nordisk products such as semaglutide and liraglutide that have been in the UK market since 2018 and 2009, respectively.” "The safety data collected from large clinical-trial programmes and post-marketing surveillance have not demonstrated a causal association between semaglutide or liraglutide and suicidal and self-harming thoughts,” he added. You can now write for wionews.com and be a part of the community. Share your stories and opinions with us here. WATCH WION LIVE HERE

Europe's drugs regulator investigating weight-loss jabs for suicide risk

<p>After spending more than two decades of&nbsp;jail, two men in US were released&nbsp;after a true crime podcast uncovered fresh evidence that all but disproved the prosecution's case against them. One of the men was also totally exonerated. As per a press&nbsp;statement from the Georgia Innocence Project, Darrell Lee Clark and his co-defendant Cain Joshua Storey were freed from imprisonment last week after serving more than 25 years for the 1996 shooting murder of their friend Brian Bowling, who was 15 at the time, as reported by the Guardian.</p>

<p>The prosecution's claim that Clark and Storey had murdered Bowling with premeditation was called into question by new information from the true-crime podcast Proof. On 18 October, 1996, Bowling had been shot in the head, leading to his death.&nbsp;Bowling told his girlfriend that he was playing Russian roulette with a pistol just before his death.&nbsp;</p>

<p>Storey, Bowling's closest friend&nbsp;had brought the rifle over. When the pistol went off, Storey was also there in the room with Bowling.</p>

<p>In connection with Bowling's death, police first accused Storey of manslaughter because they believed the shooting was accidental but nonetheless unlawful. But at the family's request, authorities started looking into Bowling's death as a murder, which brings considerably more serious penalties.</p>

<p><strong>Also read |</strong> <a href="https://www.wionews.com/world/us-conducts-successful-test-of-hypersonic-missile-says-air-force-542489">US conducts successful test of hypersonic missile, says air force</a></p>

<p>Police spoke with a woman who lived next to the Bowlings' home in order to strengthen their case. Months after the shooting, the lady said she overheard Storey and Clark discussing their plans to murder Bowling at a party. She also said that because Bowling knew too much about a theft that Storey and Clark had committed, they intended to kill him.</p>

<p>They also spoke with a person who had difficulty hearing and speaking who had been in a separate area of the house when the gunshot occurred. The witness allegedly saw Clark leaving the Bowlings' house and going through the backyard.</p>

<p>Prosecutors relied on a coroner's testimony during the trial because he claimed to have a "gut sense" that the gunshot could not have been self-inflicted in the way that it could occur if they were actually playing Russian roulette. However, since the coroner was not a medical professional, Bowling's body was never put through an autopsy.</p>

<p>In 1998, Storey and Clark were found guilty of conspiracy to commit murder and murder. At age 17, they were both given life sentences in jail.</p>

<p>Podcasters Jacinda Davis and Susan Simpson of Proof started investigating Storey and Clark's case in 2021. The two spoke with the crucial witnesses who were used by the prosecution to convict Storey and Clark.</p>

<p>They discovered that after threatening to remove her children, authorities had really forced the lady to fabricate that she had overheard Storey and Clark discussing any potential intentions to murder Bowling.<br />
The Proof podcasters also learned that the second police witness had been misconstrued during the trial and was talking about a different shooting he had seen in 1976. Actually, until the shooting, the guy had never seen a boy outside the Bowling property.</p>

<p>Clark's attorneys filed papers in September, alleging that coercion and false evidence had been used to convict Clark.</p>

<p>After judges decided that the new evidence warranted a total reversal of Clark's conviction, he was freed out from the Floyd County prison. He was virtually exonerated of all charges following that conclusion.</p>

<p><strong>Also watch|&nbsp;Former FTX founder Sam Bankman-Fried arrested in Bahamas after US files charges</strong></p>

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<p>In the meanwhile, Storey's conviction on the murder-related charges against him was vacated. However, he had previously acknowledged giving the gun to Bowling on the evening that Bowling informed his girlfriend he was playing Russian roulette.</p>

<p>In order to secure his speedy release, Storey made a deal with the prosecution to admit guilt to involuntary manslaughter in exchange for a sentence of 10 years that he had already served.</p>

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After spending more than two decades of jail, two men in US were released after a true crime podcast uncovered fresh evidence that all but disproved the prosecution's case against them.

After spending more than two decades of jail, two men in US were released after a true crime podcast uncovered fresh evidence that all but disproved the prosecution's case against them. One of the men was also totally exonerated. As per a press statement from the Georgia Innocence Project, Darrell Lee Clark and his co-defendant Cain Joshua Storey were freed from imprisonment last week after serving more than 25 years for the 1996 shooting murder of their friend Brian Bowling, who was 15 at the time, as reported by the Guardian. The prosecution's claim that Clark and Storey had murdered Bowling with premeditation was called into question by new information from the true-crime podcast Proof. On 18 October, 1996, Bowling had been shot in the head, leading to his death. Bowling told his girlfriend that he was playing Russian roulette with a pistol just before his death. Storey, Bowling's closest friend had brought the rifle over. When the pistol went off, Storey was also there in the room with Bowling. In connection with Bowling's death, police first accused Storey of manslaughter because they believed the shooting was accidental but nonetheless unlawful. But at the family's request, authorities started looking into Bowling's death as a murder, which brings considerably more serious penalties. Also read | US conducts successful test of hypersonic missile, says air force Police spoke with a woman who lived next to the Bowlings' home in order to strengthen their case. Months after the shooting, the lady said she overheard Storey and Clark discussing their plans to murder Bowling at a party. She also said that because Bowling knew too much about a theft that Storey and Clark had committed, they intended to kill him. They also spoke with a person who had difficulty hearing and speaking who had been in a separate area of the house when the gunshot occurred. The witness allegedly saw Clark leaving the Bowlings' house and going through the backyard. Prosecutors relied on a coroner's testimony during the trial because he claimed to have a "gut sense" that the gunshot could not have been self-inflicted in the way that it could occur if they were actually playing Russian roulette. However, since the coroner was not a medical professional, Bowling's body was never put through an autopsy. In 1998, Storey and Clark were found guilty of conspiracy to commit murder and murder. At age 17, they were both given life sentences in jail. Podcasters Jacinda Davis and Susan Simpson of Proof started investigating Storey and Clark's case in 2021. The two spoke with the crucial witnesses who were used by the prosecution to convict Storey and Clark. They discovered that after threatening to remove her children, authorities had really forced the lady to fabricate that she had overheard Storey and Clark discussing any potential intentions to murder Bowling. The Proof podcasters also learned that the second police witness had been misconstrued during the trial and was talking about a different shooting he had seen in 1976. Actually, until the shooting, the guy had never seen a boy outside the Bowling property. Clark's attorneys filed papers in September, alleging that coercion and false evidence had been used to convict Clark. After judges decided that the new evidence warranted a total reversal of Clark's conviction, he was freed out from the Floyd County prison. He was virtually exonerated of all charges following that conclusion. Also watch| Former FTX founder Sam Bankman-Fried arrested in Bahamas after US files charges In the meanwhile, Storey's conviction on the murder-related charges against him was vacated. However, he had previously acknowledged giving the gun to Bowling on the evening that Bowling informed his girlfriend he was playing Russian roulette. In order to secure his speedy release, Storey made a deal with the prosecution to admit guilt to involuntary manslaughter in exchange for a sentence of 10 years that he had already served. WATCH WION LIVE HERE:

US jail releases two men who spent 25 years in jail as true crime podcast challenges conviction

<p>According to Union Finance Minister Nirmala Sitharaman on Tuesday, the government has sent letters to Oppo, Vivo India, and Xiaomi in connection with incidents of potential tax fraud. The cellphone business Oppo has received notification from the Department of Revenue Intelligence (DRI) regarding a total of Rs 4.38 lakh million in customs duties. Xiaomi has received three show-cause letters, and their estimated duty due is Rs 6.5 thousand million. And the third firm is Vivo India, for which a demand notice for Rs 22 billion&nbsp;was also issued, and against which they made a voluntary deposit of Rs 600 million.</p>

<p>Additionally, according to Sitharaman, the ED is looking into 18 Vivo-founded firms where a voluntary deposit of Rs 6.2 lakh million&nbsp;has been made. Sushil Modi, a member of parliament, stated that the department had informed him that Vivo Mobile India had sent approximately Rs. 6.2 lakh million to China and its controlled territories. He then asked what other Chinese companies had sent money to China and its controlled territories and what the amounts involved were. In response to a different question, the minister stated that there are numerous telecom businesses under DRI inquiry.</p>

<p>Also Read:&nbsp;<a href="https://www.wionews.com/world/us-sanctions-russian-oligarchs-and-putins-girlfriend-for-involvement-in-ukraine-war-503057">US sanctions Russian oligarchs and Putin's 'girlfriend' for involvement in Ukraine war</a></p>

<p>In response to a BJD member's query on shady loan applications, she stated that the member had expressed "a legitimate concern." According to her, from the perspective of loan-related difficulties, applications are being misused, especially those coming from one specific country, and as a result, many of our residents are harassed and have money extorted from them. Although it has been correctly noted that these Apps are being downloaded in, say, one Odisha, there are other States about which there are reports. MeitY, Corporate Affairs, the Ministry of Finance, and a few other Departments, among others, are all continuously debating and trying to make sure that action is implemented.</p>

<p><em>(with inputs from agencies)</em></p>

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According to Union Finance Minister Nirmala Sitharaman on Tuesday, the government has sent letters to Oppo, Vivo India, and Xiaomi in connection with incidents of potential tax fraud.

According to Union Finance Minister Nirmala Sitharaman on Tuesday, the government has sent letters to Oppo, Vivo India, and Xiaomi in connection with incidents of potential tax fraud. The cellphone business Oppo has received notification from the Department of Revenue Intelligence (DRI) regarding a total of Rs 4.38 lakh million in customs duties. Xiaomi has received three show-cause letters, and their estimated duty due is Rs 6.5 thousand million. And the third firm is Vivo India, for which a demand notice for Rs 22 billion was also issued, and against which they made a voluntary deposit of Rs 600 million. Additionally, according to Sitharaman, the ED is looking into 18 Vivo-founded firms where a voluntary deposit of Rs 6.2 lakh million has been made. Sushil Modi, a member of parliament, stated that the department had informed him that Vivo Mobile India had sent approximately Rs. 6.2 lakh million to China and its controlled territories. He then asked what other Chinese companies had sent money to China and its controlled territories and what the amounts involved were. In response to a different question, the minister stated that there are numerous telecom businesses under DRI inquiry. Also Read: US sanctions Russian oligarchs and Putin's 'girlfriend' for involvement in Ukraine war In response to a BJD member's query on shady loan applications, she stated that the member had expressed "a legitimate concern." According to her, from the perspective of loan-related difficulties, applications are being misused, especially those coming from one specific country, and as a result, many of our residents are harassed and have money extorted from them. Although it has been correctly noted that these Apps are being downloaded in, say, one Odisha, there are other States about which there are reports. MeitY, Corporate Affairs, the Ministry of Finance, and a few other Departments, among others, are all continuously debating and trying to make sure that action is implemented. (with inputs from agencies)

India: Tax evasion notices issued to three Chinese mobile companies, ED investigating

<p>The Central Bureau of Investigation has justified the transfer&nbsp;of Sudhanshu Dhar Mishra, the investigating officer in the ICICI Bank case, citing his role in leaking information related to searches.</p>

<p>News agency ANI quoted a source as saying, "On January &nbsp;22 a case was registered and immediately after that, searches were proposed to be conducted. However, possibility of information about searches being leaked was suspected. Therefore discreet inquiry was conducted and role of SP Sudhanshu Dhar Mishra was strongly suspected."</p>

<p>"ICICI case is one of the very important cases that has been pending without progress. The preliminary enquiry was registered earlier in this case and was later converted into registered case", ANI further quoted.</p>

<p>"Hence he has been transferred out. A detailed inquiry into the matter is pending. Searches were under the supervision of Mohit Gupta, SP (CBI). Role of Sudhanshu Dhar Mishra in keeping the case pending and other persons if any is also been looked into, " ANI added.</p>

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<p dir="ltr" lang="en">CBI Sources: ICICI case is one of the very important cases that has been pending without progress. The preliminary enquiry was registered earlier in this case and was later converted into registered case. <a href="https://t.co/GFqDJSIdeN">https://t.co/GFqDJSIdeN</a></p>
— ANI (@ANI) <a href="https://twitter.com/ANI/status/1089458983902040065?ref_src=twsrc%5Etfw">January 27, 2019</a></blockquote>
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<p>Superintendent of Police Sudhanshu Dhar Mishra was transferred to Ranchi, a day after filing the FIR in the case against former ICICI CEO Chanda Kochhar, her husband Deepak and Videocon group MD Venugopal Dhoot on January 22.</p>

<p>The agency had carried out searches at multiple locations after the charge of the case was given to new Investigating officer Mohit Gupta, a CBI they said.</p>

<p>Justifying the transfer, the CBI pinned the blame on Mishra for keeping the preliminary enquiry pending without any reasons, PTI quoted a CBI official as saying.</p>

<p><em>(With inputs from agencies)</em></p>


The Central Bureau of Investigation has justified the transfer of Sudhanshu Dhar Mishra, the investigating officer in the ICICI Bank case, citing his role in leaking information related to searches.

The Central Bureau of Investigation has justified the transfer of Sudhanshu Dhar Mishra, the investigating officer in the ICICI Bank case, citing his role in leaking information related to searches. News agency ANI quoted a source as saying, "On January 22 a case was registered and immediately after that, searches were proposed to be conducted. However, possibility of information about searches being leaked was suspected. Therefore discreet inquiry was conducted and role of SP Sudhanshu Dhar Mishra was strongly suspected." "ICICI case is one of the very important cases that has been pending without progress. The preliminary enquiry was registered earlier in this case and was later converted into registered case", ANI further quoted. "Hence he has been transferred out. A detailed inquiry into the matter is pending. Searches were under the supervision of Mohit Gupta, SP (CBI). Role of Sudhanshu Dhar Mishra in keeping the case pending and other persons if any is also been looked into, " ANI added. CBI Sources: ICICI case is one of the very important cases that has been pending without progress. The preliminary enquiry was registered earlier in this case and was later converted into registered case. https://t.co/GFqDJSIdeN — ANI (@ANI) January 27, 2019 × Superintendent of Police Sudhanshu Dhar Mishra was transferred to Ranchi, a day after filing the FIR in the case against former ICICI CEO Chanda Kochhar, her husband Deepak and Videocon group MD Venugopal Dhoot on January 22. The agency had carried out searches at multiple locations after the charge of the case was given to new Investigating officer Mohit Gupta, a CBI they said. Justifying the transfer, the CBI pinned the blame on Mishra for keeping the preliminary enquiry pending without any reasons, PTI quoted a CBI official as saying. (With inputs from agencies)

ICICI Bank case: Probe officer transferred for 'leaking information related to searches'

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