Depression and weight problems often go hand in hand - it`s a vicious cycle you need to know about! A study of 58,745 patients` data revealed that people with obesity had a 55 percent increased risk of developing depression over time, and the depressed persons had a 58 percent increased risk of obesity. Forty-three percent of adults with depression already have obesity and women numbering more in this group than men, as found by a national survey. 
 
The suicide ideation in women with a waist circumference of over 105cm is three times more than the women with that below 82.5cm. The mental state, when obesity joins the party, is weakened by two real and debilitating attacks that run parallelly. One attack is physiological - inside the body. Obesity causes joint pain, diabetes, blood pressure etc., which are also the risk factors for depression. Additionally, excessive body fat causes chronic inflammation in the brain that leads to mood and psychiatric disorders. 
 
The other is from outside - the social stigma - how society treats people with obesity. 18.7% to 38% of people with obesity reported experiencing obesity stigma from their educators, employers, health professionals, the media, friends, and family in a WHO (World Health Organization) study. Obesity stigma is associated with increased depression, anxiety and decreased self-esteem. It can also lead to disordered eating, avoidance of physical activity, and avoidance of medical care.Will Weight Loss Improve The Mood Or Improving The Mood Help Weight-Loss? It`s not an `either-or` question say some experts. For example, dieting alone may worsen mood, particularly when it causes a pattern of repeated dieting failure. Conversely, the most common pharmacological treatments for depression have the side effect of weight gain . However, obesity seems to resist physical exercises more than depression. A study found that healthy-weight persons walked per day an average of 11,586 steps, non-depressed obesity patients did 7283 steps, and the depressed obesity patients, 6177 steps . 
 
Hence the expert advice is to jointly address obesity and depression. If you are on medications for depressions, don`t skip your tablets in pursuit of weight-loss.The next step would be to understand obesity well.What exactly is obesity? Obesity is not just a cosmetic condition as popularly perceived. It`s a complex, progressive and multifactorial disease that needs expert medical help to treat, just like clinical depression does. Obesity is measured by BMI (Body Mass Index), which is a measure of your weight in relation to your height.World Health Organization (WHO) considers a BMI more than 30 as Class 1 obesity. BMI above 35 is Class II- serious obesity and BMI above 40 is class III- severe obesity. 
 
The Indian figures are 2.5 lower than these options For Lasting Obesity Solutions For Patients With Low SpiritsMost patients with obesity who have tried diet and exercise, have had some initial success, only to regain the weight. This is not due to their lack of willpower or the wrong diet. There is documented observation that even for a non-depressed obesity patient with a BMI greater than 35, the chances of reaching a normal body weight for a lasting period of time with diet and exercise alone is less than 1 percent. 
 
Minimally invasive bariatric weight-loss surgery might be an option if your BMI is above 32.5 with depression or any other obesity-related co-morbidity; or if your BMI is more than 37.5 without any obesity-related co-morbidity . A study of 11,687 bariatric surgery patients with at least one psychiatric disorder found that a) their excess weight-loss was similar to those with no known mental health disorders, b) Quality of life improvement by 28 percent to 32 per cent was as same, and c) among patients with depression, use of anti-depressant medication dropped by about 20 percent one year after surgery and remained at that level after three years of follow-up .Now-a-days due to COVID-19, many Bariatric Surgeons offer online consultations. One could book an appointment at a center of one`s choice, and discuss the obesity issues with the expert doctor from the convenience of one`s home. 
 
Obesity can be treated with lasting results in patients with depression. The time to act against it is NOW!Disclaimer: This article is sponsored by J&amp;J in public interest. The views and opinions expressed in the article by participating doctors are based on their independent professional judgement. J&amp;J (P) Ltd, BCCL and its group publications disclaim any liability for the accuracy or consequences flowing from adherence to their expert views.This story is provided by Mediawire. ANI will not be responsible in any way for the content of this article. (ANI/Mediawire)

Depression and weight problems often go hand in hand - it`s a vicious cycle you need to know about! A study of 58,745 patients` data revealed that people with obesity had a 55 percent increased risk of developing depression over time, and the depressed persons had a 58 percent increased risk of obesity.

Depression and weight problems often go hand in hand - it`s a vicious cycle you need to know about! A study of 58,745 patients` data revealed that people with obesity had a 55 percent increased risk of developing depression over time, and the depressed persons had a 58 percent increased risk of obesity. Forty-three percent of adults with depression already have obesity and women numbering more in this group than men, as found by a national survey. The suicide ideation in women with a waist circumference of over 105cm is three times more than the women with that below 82.5cm. The mental state, when obesity joins the party, is weakened by two real and debilitating attacks that run parallelly. One attack is physiological - inside the body. Obesity causes joint pain, diabetes, blood pressure etc., which are also the risk factors for depression. Additionally, excessive body fat causes chronic inflammation in the brain that leads to mood and psychiatric disorders. The other is from outside - the social stigma - how society treats people with obesity. 18.7% to 38% of people with obesity reported experiencing obesity stigma from their educators, employers, health professionals, the media, friends, and family in a WHO (World Health Organization) study. Obesity stigma is associated with increased depression, anxiety and decreased self-esteem. It can also lead to disordered eating, avoidance of physical activity, and avoidance of medical care.Will Weight Loss Improve The Mood Or Improving The Mood Help Weight-Loss? It`s not an `either-or` question say some experts. For example, dieting alone may worsen mood, particularly when it causes a pattern of repeated dieting failure. Conversely, the most common pharmacological treatments for depression have the side effect of weight gain . However, obesity seems to resist physical exercises more than depression. A study found that healthy-weight persons walked per day an average of 11,586 steps, non-depressed obesity patients did 7283 steps, and the depressed obesity patients, 6177 steps . Hence the expert advice is to jointly address obesity and depression. If you are on medications for depressions, don`t skip your tablets in pursuit of weight-loss.The next step would be to understand obesity well.What exactly is obesity? Obesity is not just a cosmetic condition as popularly perceived. It`s a complex, progressive and multifactorial disease that needs expert medical help to treat, just like clinical depression does. Obesity is measured by BMI (Body Mass Index), which is a measure of your weight in relation to your height.World Health Organization (WHO) considers a BMI more than 30 as Class 1 obesity. BMI above 35 is Class II- serious obesity and BMI above 40 is class III- severe obesity. The Indian figures are 2.5 lower than these options For Lasting Obesity Solutions For Patients With Low SpiritsMost patients with obesity who have tried diet and exercise, have had some initial success, only to regain the weight. This is not due to their lack of willpower or the wrong diet. There is documented observation that even for a non-depressed obesity patient with a BMI greater than 35, the chances of reaching a normal body weight for a lasting period of time with diet and exercise alone is less than 1 percent. Minimally invasive bariatric weight-loss surgery might be an option if your BMI is above 32.5 with depression or any other obesity-related co-morbidity; or if your BMI is more than 37.5 without any obesity-related co-morbidity . A study of 11,687 bariatric surgery patients with at least one psychiatric disorder found that a) their excess weight-loss was similar to those with no known mental health disorders, b) Quality of life improvement by 28 percent to 32 per cent was as same, and c) among patients with depression, use of anti-depressant medication dropped by about 20 percent one year after surgery and remained at that level after three years of follow-up .Now-a-days due to COVID-19, many Bariatric Surgeons offer online consultations. One could book an appointment at a center of one`s choice, and discuss the obesity issues with the expert doctor from the convenience of one`s home. Obesity can be treated with lasting results in patients with depression. The time to act against it is NOW!Disclaimer: This article is sponsored by J&J in public interest. The views and opinions expressed in the article by participating doctors are based on their independent professional judgement. J&J (P) Ltd, BCCL and its group publications disclaim any liability for the accuracy or consequences flowing from adherence to their expert views.This story is provided by Mediawire. ANI will not be responsible in any way for the content of this article. (ANI/Mediawire)

Obesity and depression feed off each other: Study

A hormone that can suppress food intake and increase the feeling of fullness in mice has shown similar results in humans and non-human primates, says a new study&nbsp;published in the journal <a href="https://www.sciencedaily.com/releases/2020/11/201124122921.htm">eLife</a>.

The hormone, called Lipocalin-2 (LCN2), could be used as a potential treatment in people with obesity whose natural signals for feeling full no longer work.

Also read:&nbsp;<a href="https://www.wionews.com/world/britain-set-to-ban-online-advertisements-of-junk-food-to-fight-obesity-342241">Britain set to ban online advertisements of junk food to fight obesity</a>

LCN2 is mainly produced by bone cells and is found naturally in mice and humans. Studies in mice have shown that giving LCN2 to the animals long term reduces their food intake and prevents weight gain, without leading to a slow-down in their metabolism.

"LCN2 acts as a signal for satiety after a meal, leading mice to limit their food intake, and it does this by acting on the hypothalamus within the brain," explains lead author Peristera-Ioanna Petropoulou, who was a Postdoctoral Research Scientist at Columbia University Irving Medical Center, New York, US, at the time the study was carried out and is now at the Helmholtz Diabetes Center, Helmholtz Zentrum Munchen, Munich, Germany.

Also read:&nbsp;<a href="https://www.wionews.com/world/obesity-is-a-major-covid-19-risk-factor-says-epidemiologist-291788">Obesity is a major COVID-19 risk factor, says epidemiologist</a>

"We wanted to see whether LCN2 has similar effects in humans and whether a dose of it would be able to cross the blood-brain barrier."

The team first analysed data from four different studies of people in the US and Europe who were either normal weight, overweight or living with obesity.

Also read:&nbsp;<a href="https://www.wionews.com/world/new-zealand-scores-f-for-failure-as-unicef-report-on-obesity-youth-suicide-reveal-dismal-results-325176">New Zealand scores 'F for failure' as Unicef report on obesity, youth suicide reveal dismal results</a>

The people in each study were given a meal after an overnight fast, and the amount of LCN2 in their blood before and after the meal was studied.

The researchers found that in those who were of normal weight, there was an increase in LCN2 levels after the meal, which coincided with how satisfied they felt after eating.By contrast, in people who were overweight or had obesity, LCN2 levels decreased after a meal.

Based on this post-meal response, the researchers grouped people as non-responders or responders. Non-responders, who showed no increase in LCN2 after a meal, tended to have a larger waist circumference and higher markers of metabolic disease -- including BMI, body fat, increased blood pressure and increased blood glucose.

Remarkably, however, people who had lost weight after gastric bypass surgery were found to have a restored sensitivity to LCN2 -- changing their status from non-responders before their surgery, to responders afterwards.

Taken together, these results mirror those seen in mice and suggest that this loss of post-meal LCN2 regulation is a new mechanism contributing to obesity and could be a potential target for weight-loss treatments.

After verifying that LCN2 can cross into the brain, the team explored whether treatment with the hormone might reduce food intake and prevent weight gain. To do this, they treated monkeys with LCN2 for a week.

Scientists observed&nbsp;a 28 per cent&nbsp;decrease in food intake compared with that before treatment within a week, and the monkeys also ate 21 per cent&nbsp;less than their counterparts who were treated only with saline.

Moreover, after only one week of treatment, measurements of body weight, body fat and blood fat levels showed a declining trend in treated animals."

We have shown that LCN2 crosses to the brain, makes its way to the hypothalamus and suppresses food intake in non-human primates," concludes senior author Stavroula Kousteni, Professor of Physiology and Cellular Biophysics at Columbia University Irving Medical Center.

"Our results show that the hormone can curb appetite with negligible toxicity and lay the groundwork for the next level of LCN2 testing for clinical use."

A hormone that can suppress food intake and increase the feeling of fullness in mice has shown similar results in humans and non-human primates, says a new study published in the journal eLife.

A hormone that can suppress food intake and increase the feeling of fullness in mice has shown similar results in humans and non-human primates, says a new study published in the journal eLife. The hormone, called Lipocalin-2 (LCN2), could be used as a potential treatment in people with obesity whose natural signals for feeling full no longer work. Also read: Britain set to ban online advertisements of junk food to fight obesity LCN2 is mainly produced by bone cells and is found naturally in mice and humans. Studies in mice have shown that giving LCN2 to the animals long term reduces their food intake and prevents weight gain, without leading to a slow-down in their metabolism. "LCN2 acts as a signal for satiety after a meal, leading mice to limit their food intake, and it does this by acting on the hypothalamus within the brain," explains lead author Peristera-Ioanna Petropoulou, who was a Postdoctoral Research Scientist at Columbia University Irving Medical Center, New York, US, at the time the study was carried out and is now at the Helmholtz Diabetes Center, Helmholtz Zentrum Munchen, Munich, Germany. Also read: Obesity is a major COVID-19 risk factor, says epidemiologist "We wanted to see whether LCN2 has similar effects in humans and whether a dose of it would be able to cross the blood-brain barrier." The team first analysed data from four different studies of people in the US and Europe who were either normal weight, overweight or living with obesity. Also read: New Zealand scores 'F for failure' as Unicef report on obesity, youth suicide reveal dismal results The people in each study were given a meal after an overnight fast, and the amount of LCN2 in their blood before and after the meal was studied. The researchers found that in those who were of normal weight, there was an increase in LCN2 levels after the meal, which coincided with how satisfied they felt after eating.By contrast, in people who were overweight or had obesity, LCN2 levels decreased after a meal. Based on this post-meal response, the researchers grouped people as non-responders or responders. Non-responders, who showed no increase in LCN2 after a meal, tended to have a larger waist circumference and higher markers of metabolic disease -- including BMI, body fat, increased blood pressure and increased blood glucose. Remarkably, however, people who had lost weight after gastric bypass surgery were found to have a restored sensitivity to LCN2 -- changing their status from non-responders before their surgery, to responders afterwards. Taken together, these results mirror those seen in mice and suggest that this loss of post-meal LCN2 regulation is a new mechanism contributing to obesity and could be a potential target for weight-loss treatments. After verifying that LCN2 can cross into the brain, the team explored whether treatment with the hormone might reduce food intake and prevent weight gain. To do this, they treated monkeys with LCN2 for a week. Scientists observed a 28 per cent decrease in food intake compared with that before treatment within a week, and the monkeys also ate 21 per cent less than their counterparts who were treated only with saline. Moreover, after only one week of treatment, measurements of body weight, body fat and blood fat levels showed a declining trend in treated animals." We have shown that LCN2 crosses to the brain, makes its way to the hypothalamus and suppresses food intake in non-human primates," concludes senior author Stavroula Kousteni, Professor of Physiology and Cellular Biophysics at Columbia University Irving Medical Center. "Our results show that the hormone can curb appetite with negligible toxicity and lay the groundwork for the next level of LCN2 testing for clinical use."

Switch off hunger? Scientists discover hormone that could tackle obesity

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Obesity and depression feed off each other: Study

Switch off hunger? Scientists discover hormone that could tackle obesity