Mohammed Shami celebrates during the match. Photograph:( Reuters )
India need 245 runs to win the fourth Test as England were dismissed for 271 in their second innings after resuming on 260 for eight.
The fourth day of Southampton Test resumed with Sam Curran and a new batsman Stuart Board.
While India's star pacer Shami gave the required start to have Stuart Broad caught behind for a golden duck on the first ball of the day.
That left Shami, for the second time in the match, on a hat-trick at the start of his next over after he had removed Adil Rashid with the last ball of Saturday's play.
Sam Curran, 37 not out overnight, survived the hat-trick.
Curran, however, could not complete the half-century as he was run out for 46 going for a second by Ishant Sharma's throw to wicket-keeper Rishabh Pant.
Pace bowler Shami led India's attack with four wickets for 57 runs from 16 overs. He also dismissed Joe Root with a splendid direct hit from mid-on.
The set target is a record run-chase for India if they were to win this match to level the series.
The most India have made to win in the fourth innings of a Test in England is 174 at The Oval in 1971. That match also marked their first Test-match win on English soil.
All out! England add just 11 to their overnight total, Sam Curran the last to fall for 46, ran out by Ishant Sharma. India require 245 runs to win and take the series to a decider!#ENGvIND LIVE ➡️ https://t.co/VUru4XV87u pic.twitter.com/pfpBJTEs4f— ICC (@ICC) September 2, 2018
Jos Buttler, who lost his wicket to Ishant Sharma after scoring 69 runs, salvaged England's second innings as his team was slumped to 92 for four.
Alastair Cook (12) and Keaton Jennings (36) lost their wickets to Jasprit Bumrah and Mohammed Shami respectively.
Moeen Ali was surprisingly promoted to number three instead of Root, lost his wicket to Ishant Sharma.
England's skipper Joe Root was looking good on the wickets when he was called for an unnecessary single by Ben Stokes and failed to beat Shami's direct hit.
Stokes displayed a good defense as he faced 110 balls but managed to score just 30 runs before losing his wicket to Ashwin.
On the second day, Moeen Ali took five for 63 as India were dismissed for 273 in reply to England's first-innings 246, a lead of 27 runs.
So far, England lead this five-match series 2-1.