Bourdain, whose career catapulted him from washing dishes at New York restaurants to dining in Vietnam with President Barack Obama, hanged himself in a hotel room near Strasbourg, France, where he had been working on an upcoming episode of his program.
AnthonyBourdain was at the forefront of the #MeToo movement.
"I came out of a brutal, oppressive business that was historically unfriendly to women... I knew a lot of women, it turned out, who had stories about their experience, about people I knew, who did not feel I was the sort of person they could confide in," said Bourdain in a January interview with The Daily Show.
After Kate Spade
His death comes three days after American designer Kate Spade, who built a fashion empire on her signature handbags, was found dead of suicide in her New York apartment on Tuesday.
Suicide rates rose in nearly every US state from 1999 to 2016, according to data from the US Centers for Disease Control and Prevention on Thursday. Nearly 45,000 people committed suicide in 2016, making it one of three leading causes of death that are on the rise, along with Alzheimer's disease and drug overdoses.
Executive chef at Brasserie Les Halles
Bourdain climbed the culinary career ladder to become executive chef at New York's former Brasserie Les Halles restaurant.
His fame began to grow exponentially in 1999 when the New Yorker magazine published his article "Don't Eat Before Reading This," which he developed into the 2000 book, "Kitchen Confidential: Adventures in the Culinary Underbelly."
Never ceased to amaze
Brash and opinionated, he also spoke openly about his use of drugs and addiction to heroin earlier in his life.
"His love of great adventure, new friends, fine food and drink and the remarkable stories of the world made him a unique storyteller," the network said in a statement. "His talents never ceased to amaze us."
Bourdain told the New Yorker in 2017 that his idea for "Parts Unknown," which was in its 11th season, was traveling, eating and doing whatever he wanted. The show roamed from out-of-the-way restaurants to the homes of locals, providing what the magazine called "communion with a foreign culture so unmitigated that it feels practically intravenous."
'He taught us about food'
When Obama went to Hanoi, Vietnam in May 2016, he met Bourdain at a casual restaurant for a $6 meal of noodles and grilled pork.
"He taught us about food — but more importantly, about its ability to bring us together," Obama tweeted on Friday, along with a picture showing the two drinking beer in Hanoi. "To make us a little less afraid of the unknown. We'll miss him."
Donald Trump shocked
President Donald Trump called Bourdain's death "very shocking."
"I enjoyed his show, he was quite a character," Trump told reporters at the White House.