The shooting took place in the parking lot of Club Blu just after 12:30 a.m. ET and police found "several victims suffering from gunshot wounds," the Fort Myers Police Department said in a statement. Injuries ranged from minor to life-threatening.
Three people had been detained for questioning, the police said, and the area was "deemed safe" although roads in the vicinity were closed as the investigation continues.
The crime scene is still considered to be active, as police determine what had occurred, and what was the motive. Investigators are working to identify the victims and notify the next of kin.
There were reportedly three different shooting scenes, but it is not known if they are linked.
The first scene is near the club, while the second and third locations are at junctions nearby. A witness told WPTV that someone in a black Honda SUV was shooting randomly from the vehicle at the homes along the road at the third scene.
Reporters saw at least thirty shell casings in the area and cops investigating the incident. A third incident occurred around 3 am near the intersection of Marsh and Woodside avenues.
Early reports suggest one of the dead victims is a 14-year-old boy. Police are at the scene which eye-witnesses say is covered by at least two dozen evidence markers indicating bullet casings. ABC 7 has reported that at least 15 people have been hurt and two are dead.
Earlier, Lee Memorial Hospital told WION in a statement: "Victims of an early morning shooting at Club Blu in Fort Myers began arriving at Lee Memorial Hospital early Monday morning at approximately 1.30 am. Ages of the patients ranged from 12 to 27. Sixteen people were treated in the trauma center and emergency department. While one victim expired at the hospital, two were admitted to the Intensive Care Unit, one is in serious condition and one victim is critical. Another was admitted to the hospital in fair condition. All others were treated and released. One of the victims from the shooting incident was treated and released at Cape Coral Hospital."
The shooting comes six weeks after a massacre at a nightclub in the Florida city of Orlando, in which a lone gunman killed 49 in the deadliest mass shooting in US history.